Thyroid function, pulmonary arterial hypertension and scleroderma

Marasini, Bianca; Massarotti, Marco; Cossutta, R.

doi:10.1016/j.amjmed.2004.09.020

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Seventeen SSc patients with high pulmonary systolic pressure (>35 mmHg) were studied in another article ( 44 ). High pulmonary pressure in these SSc patients was not associated with the type of SSc, or age; however, five SSc patients (12.5%) had alteration of the thyroid function (two cases of hypothyroidism, three of hyperthyroidism).…”

Section: Clinical Aspects Of Ssc and Thyroid Disordersmentioning

confidence: 99%

“…Furthermore, hypothyroid SSc patients had higher pressure levels, with respect to hyperthyroid SSc (46 versus 37 mmHg, respectively), even if not significantly. The lack of significant differences in pressure levels between hypothyroid, or hyperthyroid SSc, and the low frequency of ATA in pulmonary hypertension associated with SSc, suggest a vasomotor role of thyroid hormones, rather than an autoimmune mechanism ( 44 ).…”

Section: Clinical Aspects Of Ssc and Thyroid Disordersmentioning

confidence: 99%

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Associations between Systemic Sclerosis and Thyroid Diseases

et al. 2017

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We have reviewed scientific literature about the association of systemic sclerosis (SSc) and thyroid disorders. A high incidence, and prevalence, of new cases of autoimmune thyroiditis (AT) and/or hypothyroidism have been shown in sclerodermic patients (overall in the female gender). An association among a Th1 immune-predominance, low vitamin D levels, and AT have been also shown in SSc patients. Cases of Graves’ disease (GD) have been described in SSc patients, too, according with the higher prevalence of thyroid autoimmunity. It has been also shown a higher prevalence of papillary thyroid cancer (PTC), in association with AT, in SSc patients. However, in order to confirm results about GD and thyroid cancer, studies in larger number of patients with SSc are needed. During the follow-up of SSc patients it would be appropriate to monitor carefully their thyroid status. The abovementioned data strongly suggest a periodic thyroid function follow-up in female SSc patients [showing a borderline high (although in the normal range) thyroid-stimulating hormone level, antithyroid peroxidase antibody positivity, and a small thyroid with a hypoechoic pattern], and, when necessary, appropriate treatments. In conclusion, most of the studies show an association among SSc, AT, and hypothyroidism, such as an increased prevalence of TC overall in SSc patients with AT. Only few cases of GD have been also described in SSc.

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Section: Clinical Aspects Of Ssc and Thyroid Disordersmentioning

confidence: 99%

Section: Clinical Aspects Of Ssc and Thyroid Disordersmentioning

confidence: 99%