Thyroid Function in Protein-Depleted Rats

Florsheim, Warner H.; Suhr, Biruta Z.; Mirise, Raymond T.; Williams, A. D.

doi:10.1677/joe.0.0460093

Cited by 13 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent measurements of plasma free T4 showed normal or elevated results in kwashiorkor, and normal or low levels in marasmus (Graham et af., 1973). Thyroid 13'1 uptake is reported as reduced or normal in marasmus (Beas et af., 1966), and normal in kwashiorkor (Gopalan, 1969), but interpretation may be complicated by impairment of iodide clearance as shown in experimental models (Florsheim et al, 1970). There have, however, been reports of deficient organification of iodide with abnormal perchlorate discharge (Gopalan, 1969) and an abnormally high MIT, DIT: T3, T4 ratio in human plasma (Godard & Lemarchand-Beraud, 1973) and rat thyroid (Florsheim et al, 1970) as well as a low thyroid to serum radioiodide concentration ratio in animals (Srebnik et al, 1963;Cowan & Margossian, 1966).…”

Section: P I T U I T a R Y -T H Y R O I D F U N C T I O Nmentioning

confidence: 99%

Endocrine Function in Protein‐calorie Malnutrition

Pimstone

1976

Clinical Endocrinology

View full text Add to dashboard Cite

Undernutrition is widespread. In spite of the research and development being directed towards its prevention and alleviation, the weight of numbers as well as social, cultural, economic and technological considerations make eradication unlikely in the foreseeable future. Ironically, malnutrition is often endemic in areas in which sophisticated medical facilities exist; the problem clearly goes deeper than the mere availability of medical care. But this curious juxtaposition of poverty and medical sophistication has allowed numerous workers to study endocrine function in protein-calorie malnutrition (PCM). As hormones such as glucagon, insulin, growth hormone and cortisol are concerned with the efficient utilization of food, storage and expenditure of energy, and the latter three hormones with synthesis of body protein, it has been suggested that adaptive changes based on alterations in hormone secretion of function might allow for better survival of the threatened individual (Monckeberg, 1968); this conclusion, however, must be regarded as speculative at present; an alternative explanation might be that they are non-specific consequences of severe nutritional deprivation.This review is not primarily concerned with hormonal changes in prolonged fasting, nor will it refer in great depth to animal models of malnutrition which, while they have the advantage of producing more precise quantitation of the deficit, may not always be relevant to the situation in man. For infantile malnutrition is not merely the deprivation of proteins and calories ; it is inevitably associated with variable degrees of vitamin and mineral deficiency, intercurrent infection and electrolyte changes. To what extent hormonal changes are attributable to malnutrition as opposed to associated phenomena is not always apparent, but these might be very relevant in considering the pathogenesis of endocrine dysfunction in the human as opposed to the experimental context.

show abstract

Section: P I T U I T a R Y -T H Y R O I D F U N C T I O Nmentioning

confidence: 99%

Endocrine Function in Protein‐calorie Malnutrition

Pimstone

1976

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…Whether the decreased rate of secretion from the thyroid observed during feed restriction can be considered due to a decrease in TSH secretion, or a lack of response of the thyroid to circulating TSH, or both, is unclear. In man SUbjected to protein-caloric malnutrition, and in protein-depleted rats, no changes in circulating TSH were observed (Florsheim et al 1970;Chopra and Smith 1975). However, normal.…”

Section: Discussionmentioning

confidence: 92%

“…The cause of this decrease is not clearly established, since measurements of circulating TSH in rats and humans on inadequate diets which depress thyroid secretion do not necessarily show reduced TSH concentrations (Srebnik et al 1963;Florsheim et al 1970;Chopra and Smith 1975).…”

Section: Introductionmentioning

confidence: 99%

Responses of Thyroid Activity to Feed Restriction in the Goat

Abdullah¹,

Falconer²

1977

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

A study of the effect of restriction of feed intake on the deiodination, faecal excretion, -distribution and secretion of thyroid hormones was carried out in a group of-eight young inale goats. ' In the control goats fed ad libitum no changes in the concentration of circulating thyroxine were observed with increasing age -or body weight during the experimental period; however, an increase in thyroxine secretion rate per animal was apparent with increasing age or body weight of'the goats.In feed-restricted goats, no changes in the peripheral deiodination of [125I]thyroxine were observed, 'though significantly reduced faecal excretion of [125I]thyroxine was seen in goats' restricted to 50 or 20% of their ad libitum feed intake. Both thyroxine turnover rate and thyroxine distribution vollime were reduced by feed restriction. The secretion'rate of thyroxine was reduced to 45 % of the rate in ad libitum fed animals when feed intake was restricted to 20 %. Calculation 'of thyroxine secretion rate per kilogramo. 75 body weight showed a highly significant correlation with feed intake.It was concluded that the marked reduction in thyroid activity occurring when feed restriction was imposed would be expected to cause a physiologically significant reduction in metaholic activity.

show abstract

“…Several workers have observed the involution of the thyroid gland in mal-nourised rats [12][13][14][15]. It was also reported that the pituitary TSH content was reduced by protein deprivation in rats 16.17).…”

Section: Resultsmentioning

confidence: 99%

Effect of Malnutrition on Thyrotropin Releasing Hormone-induced Thyroxine Secretion in Rats

Kanagawa¹,

Matsui²,

Yano³

et al. 1986

Nihon Chikusan Gakkaiho

View full text Add to dashboard Cite

The effect of nutritional plane on cattle growth has been studied from the viewpoint of bone growth in a series of our study1,2). It was suggested from previous reports1,2) that the retardation of bone growth might be owing to reduced thyroxine secretion in malnourished calves.Several reports indicated the decrease in plasma total thyroxine concentrations in malnourished4-8) and fasting rats7). It is suggested that fasting decreases serum thyroxine7) and thyrotropin (TSH)8) concentrations, and thyrotropin releasing hormone (TRH) content in the hypothalamus7) in rats. However, it is not clear how the decrease in serum thyroxine concentration is induced in malnourished rats. The present study was, therefore, undertaken to elucidate the mechanism of reduced thyroxine secretion caused by malnutrition by manifesting the thyroxine response to the injection of TRH in rats. Material and MethodsTwenty four male Wistar rats, weighing about 100g, were used in this experiwith 14 hr light and 10 hr darkness.They were divided into 2 groups; normal diet (control) group and low-protein and low-calorie diet (malnourished) one. Control diet contained 48% of starch and 25% of casein, and rats in malnourished group were given a diet composed of 24% of starch and 6% of casein 3). Every rat was housed in an individual cage. All animals were weighed daily, and the daily amount of diet was determined by the formula:

show abstract

Thyroid Function in Protein-Depleted Rats

Cited by 13 publications

References 5 publications

Endocrine Function in Protein‐calorie Malnutrition

Endocrine Function in Protein‐calorie Malnutrition

Responses of Thyroid Activity to Feed Restriction in the Goat

Effect of Malnutrition on Thyrotropin Releasing Hormone-induced Thyroxine Secretion in Rats

Contact Info

Product

Resources

About