Thyroid function in multidrug-resistant tuberculosis patients with or without human immunodeficiency virus (HIV) infection before commencement of MDR-TB drug regimen

Ige, Olusoji Mayowa; Akinlade, Kehinde Sola; Rahamon, Sheu Kadiri; Edem, Victory Fabian; Arinola, OG

doi:10.4314/ahs.v16i2.30

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…In the current study, 17.3% of MDR-TB patients had subclinical hypothyroidism and 4 (2.5%) had overt hypothyroidism. The study reported by Ige et al in 2016 (7.8%) from Nigeria 26 indicated a lower proportion of subclinical hypothyroidism than our study finding. Moreover, the study reported by Bares et al in 2016 27 showed higher subclinical (40%) and overt (38%) hypothyroidism than this study.…”

Section: Discussioncontrasting

confidence: 72%

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Biranu¹,

Wolde²,

Negesso³

et al. 2021

IDR

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Background:The emergence of MDR-TB is a global public health problem. Hypothyroidism is one of the severe adverse drug reactions (ADRs) in MDR-TB patients on treatment. Representative data on hypothyroidism and its associated factors among MDR-TB patients are lacking. Objective: To determine thyroid profiles and associated risk factors among multidrugresistant TB patients during therapy with anti-MDR-TB regimen in Saint Peter Specialized Hospital Addis Ababa, Ethiopia from January to November 2020. Methods: A cross-sectional study was conducted in MDR-TB patients in Addis Ababa, Ethiopia. A total of 162 patients, who were older than 18 years, had bacteriologically confirmed MDR-TB and on treatment for more than one month were enrolled consecutively from the TB registration book. However, critically sick patients and those who were receiving additional drugs known to cause severe ADRs were excluded. Simple descriptive statistics were used to present the socio-demographic and clinical characteristics of the patients. A logistic regression model was used to assess the association between independent and dependent variables. A p-value <0.05 was considered as statistically significant in all analyses. Results: Mean age of the study participant was 35.9 ± 13.6 years. The prevalence of hypothyroidism was 32 (19.8%). The presence of co-morbidity, being underweight, and prothionamide use were significantly associated with hypothyroidism in MDR-TB patients on treatment. Conclusion: Hypothyroidism occurs commonly among MDR-TB patients. Presence of comorbidity, being underweight, and prothionamide drug use are the factors associated with hypothyroidism. Monitoring of thyroid function test during MDR-TB treatment and factors associated with hypothyroidism require attention to prevent complication.

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Section: Discussioncontrasting

confidence: 72%

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Biranu¹,

Wolde²,

Negesso³

et al. 2021

IDR

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“…Ige OM et al . [ 29 ] study found 4.35%, 7.83%, and 1.74% of patients had sick euthyroid syndrome, subclinical hypothyroidism, and subclinical hyperthyroidism respectively. Dash M et al .…”

Section: Discussionmentioning

confidence: 99%

Socioepidemiological status and clinical outcome of MDR TB patients in a tertiary medical college in Southern Odisha

Behera

Dash

2022

Journal of Family Medicine and Primary Care

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Introduction: India accounts for one-fourth of the global TB burden. The load of drug-resistant TB is of foremost attention and concern at international, regional, and national levels. As per estimates of TB burden in India in 2018, the MDR/RR-TB incidence was 1.30 lakhs. Objectives: Socioepidemiological status and clinical outcome of MDR TB patients in a teaching hospital in tribal area of southern Odisha from 2012-2020. Material and Methods: This is a retrospective observational study accepted by the Institutional Ethics Committee of this tertiary medical college & hospital to which the DRTB centre is attached with the agreement of the program administrators. Inclusion Criteria: Patients with >15 years of age, those patients with pulmonary and extrapulmonary tuberculosis with normal liver enzymes. Exclusion Criteria: Patients having abnormal liver enzymes before treatment, pregnant ladies and children <15 years of age. Results: A total of 40 MDR TB patients were included. The patients’ mean age was 36.65 ± 11.75 years. 65% of the patients had BMI below 18.5 kg/m 2 . 17.5% of patients had comorbidities. Approximately 45% had successful treatment outcomes. Poor treatment outcome includes loss to follow-up in 22.5% and mortality in 12.5%. We did not find any treatment failure. Conclusion: Treatment success outcomes occurred in less than half of the cases. The main predictors of mortality among MDR-TB patients were the presence of comorbidities like anaemia, baseline leucocytosis or lymphopenia, hypoproteinaemia, HIV sero-positivity and smaller baseline BMI.

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“…The patients in our series were young in precarious socioeconomic circumstances, in agreement with trends reported. 2,3,8 While thyroid TB was previously found only in young women, 9 HIV infection, affecting men and women equally, is changing this trend.…”

Section: Discussionmentioning

confidence: 97%

Tuberculosis of the thyroid in Togo: a clinicopathologic study of 11 presumed cases

et al. 2018

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Tuberculosis (TB) remains a real public health concern in Africa; thyroid localisation of the disease is a very rare form of extrapulmonary TB. We conducted a descriptive and cross-sectional study on all histologically proved cases of thyroid TB diagnosed in Togo over the last 20 years. Eleven cases of TB of the thyroid were identified, of which nine were in women, with an average age of 29.4 ± 0.2 years. The clinical signs were the presence of a nodule in seven, an abscess in three and a swelling with cutaneous fistulisation in one. Thyroid involvement alone was found in four, associated with pleuropulmonary TB in six and mammary TB in one. Human immunodeficiency virus (HIV) co-infection was present in six. All histopathology results showed inflammatory granulomata with caseous necrosis. The clinical features are often misleading and pose a real diagnostic problem, especially with differentials of simple abscess and cancer.

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Thyroid function in multidrug-resistant tuberculosis patients with or without human immunodeficiency virus (HIV) infection before commencement of MDR-TB drug regimen

Cited by 6 publications

References 15 publications

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Thyroid Profile and Factors Associated with Hypothyroidism Among Multidrug-Resistant Tuberculosis Patients Attending Saint Peter’s Specialized Hospital Addis Ababa, Ethiopia

Socioepidemiological status and clinical outcome of MDR TB patients in a tertiary medical college in Southern Odisha

Tuberculosis of the thyroid in Togo: a clinicopathologic study of 11 presumed cases

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