Thyroid Function in Kuwaiti Subjects with Down’s Syndrome

Ali, Fawzi E.; Bayoumy, Hossam A.; Mohammad, Abdul Salam R.; Al-Busairi, Waleed A.; Al-Othman, Abdul Naser A.

doi:10.1159/000065807

Cited by 12 publications

(21 citation statements)

References 19 publications

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“…TSH levels were not so elevated (5.1 to 29.9 µU/ml), as observed in several studies. [1][2][3][4][5][6][7][8][9][10] There was no difference in sex distribution in our patient population, similarly to what has been described in other studies. 12,13,21 The fact that only eight (4.7%) of 169 patients were following a treatment suggests that most of them had an isolated elevation of TSH levels hyperthyrotropinemia; corroborating the results found by several authors who studied DS patients.…”

Section: Discussionsupporting

confidence: 91%

“…The prevalence of thyroid dysfunction in DS is higher than in the general population, ranging from ORIGINAL ARTICLE 20 to 66%, depending on the study design, sample size, geographical region, age group and on whether cases of hypothyroidism and/or hyperthyroidism were analyzed. [1][2][3][4][5][6][7][8][9][10] These studies conclude that, due to such high prevalence, it is necessary to assess the thyroid function in the followup of DS patients.…”

Section: Introductionmentioning

confidence: 89%

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Avaliação etiológica da hipertirotropinemia em crianças com síndrome de Down

Dias¹,

Nunes²,

Araújo³

et al. 2005

J. Pediatr. (Rio J.)

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Objective: To study the prevalence of increased TSH level and its probable cause in children with Down s syndrome treated at Policlínica Antônio Cândido. Methods:The data were colleted using medical records of 169 patients. Of these, 46 patients, whose TSH increased at some time during their follow-up, were re-evaluated. In these patients, TSH, free T4, total T4 and thyroid peroxidase autoantibody (anti-TPO) levels were measured. Thyroid ultrasound, iodine-131 scintigraphy, and a perchlorate discharge test were performed.Results: In 169 children, 86 (50.8%) of whom were male, aged between 1-16 years (median 4 years), 67 (39.6%) presented increased TSH levels. Out of these 67 patients, 46 were prospectively studied. In 31 (67.4%) of them serum TSH returned to normal levels; in 11, TSH remained between 5 and 10 µU/ml, three (6.5%) had a TSH level over 10 µU/ml and one (2.2%) had hyperthyroidism. The diagnoses in 34 patients who were fully studied were: goiter in five (14.7%); Hashimoto s thyroiditis in four (5.9%); hypoplasia in three (8.8%) and iodide organification defect in one (2.9%). The increased TSH levels had a statistically positive relationship with anti-TPO (p = 0.02), but not with gender, abnormal ultrasound or scintigraphy findings. TSH levels did not have any relationship with persistent hyperthyrotropinemia. Conclusions:In patients with Down s syndrome, slightly elevated and transient TSH levels are frequently detected. Positive anti-TPO antibody test is a key factor in the follow-up of these patients because of its potential risk of progression to manifest thyroid disease.J Pediatr (Rio J). 2005;81(1):79-84: Down s syndrome, hyperthyrotropinemia, autoimmune thyroid disease, thyrotropin, hyperthyroidism.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 89%

Avaliação etiológica da hipertirotropinemia em crianças com síndrome de Down

Dias¹,

Nunes²,

Araújo³

et al. 2005

J. Pediatr. (Rio J.)

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“…Das alterações cromossômicas compatíveis com a vida, a síndrome de Down (SD) é a mais freqüente, apresentando uma intrigante associação com anomalias tireoidianas. A prevalência de disfunção tireoidiana na SD é maior do que na população geral, variando entre 20 a 66%, dependendo da linha de estudo, do tamanho da amostra estudada, da região geográfica, da faixa etária e da inclusão ou não de casos de hipo-e/ou hipertireoidismo [1][2][3][4][5][6][7][8][9][10] . Esses estudos concluem que, devido a essa prevalência elevada, faz-se necessária a avaliação laboratorial periódica da função dessa glândula nos indivíduos com SD.…”

Section: Introductionunclassified

“…Constatou-se maior incidência no sexo feminino e maior número de pacientes com TSH elevado com o aumento da idade. Vários estudos têm relatado um aumento na incidência de ATPO positivo e/ou alterações nos valores de T4 e TSH com o avançar da idade 9,[20][21][22] . Rubello et al 7 encontraram uma elevada prevalência de ATPO circulante em todas as idades nos pacientes com SD (incluindo os muito jovens) e uma distribuição semelhante nos dois gêneros.…”

Section: Introductionunclassified

Etiological assessment of hyperthyrotropinemia in children with Down's syndrome

et al. 2005

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“…Down sendromunda hipotiroidi sıklığı çeşitli çalışmalarda %13.7-51 arasında bildirilmiştir (3,15,16). Çalışmamızda da literatürle uyumlu olarak olgularımızın %38.3'ünde hipotiroidi mevcuttu.…”

Section: Gereç Ve Yöntemunclassified

Clinical and Echocardiographic Evaluation of Children with Down Syndrome

Gül¹,

Gürses²,

Doğan³

2016

Turkish J Pediatr Dis

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ÖzETAmaç: Down sendromu sık rastlanan kromozomal hastalıklardan biridir. Bu hastalarda doğumsal kalp hastalıkları sık görülmekte ve sendromdaki en önemli mortalite ve morbidite nedenini oluşturmaktadır. Çalışmada, Çocuk Kardiyoloji Ünitemize Down sendromu tanısı ile başvuran hastaların demografik özellikleri, eşlik eden doğumsal kalp hastalıkları ve ek anomalileri değerlendirildi. Bulgular: Down sendromlu hastaların %77.5'in de doğumsal kalp hastalığı mevcuttu. Bu hastaların %49.3'ün de sekundum tip atriyal septal defekt, %33.7'sinde ventriküler septal defekt, %18.1'inde komplet tip atriyoventriküler septal defekt, %10.8'inde patent duktus arteriyosuz, %3.7'sinde biküspit aortik kapak saptandı. Birer olguda ise pulmoner stenoz, aort koarktasyonu ve fallot tetralojisi vardı. Eşlik eden ek anomalilere bakıldığında; hastaların %38.3'ün dehipotiroidi, %6.5'inde görme bozukluğu, %5.6'sında işitme problemleri, %3.7'sinde inmemiş testis vardı. Hipotiroidisi olan hastalarda kardiyak defektlerin daha fazla olduğu gözlendi (p<0.05). Gereç veSonuç: Down sendromlu hastalarda doğumsal kalp hastalıkları sık görülmektedir. Klinik belirti ve bulgu olmasa da bu çocukların kardiyak açıdan değerlendirmesi, erken tanıyı sağlayacak ve ileride ortaya çıkabilecek geri dönüşümsüz komplikasyonların gelişmesini engelleyecektir.Anahtar Sözcükler: Çocuk, Doğumsal kalp hastalığı, Down sendromu ABSTRAcTObjective: Down syndrome is one of the most common chromosomal disorders. Congenital heart diseases in patients with Down syndrome are seen frequently and the most important cause of morbidity and mortality in this syndrome. In this study, the demographic characteristics, comorbid diseases and congenital heart anomalies of patients with Down syndrome admitted to our Pediatric Cardiology Department were evaluated. Material and Methods:The data of 107 subjects with Down syndrome admitted to our Pediatric Cardiology Department between January 2010 and December 2015 were evaluated. Results:Congenital heart diseases were presented in 77.5% of the patients with Down syndrome. There was a secundum atrial septal defect in 49.3%, ventricular septal defect in 33.7%, complete type atrioventricular septal defect in 18.1%, patent ductus arteriosus in 10.8%, and bicuspid aortic valve in 3.7%. There was pulmonary stenosis in one case, aorta coarctation in one case and Tetralogy of Fallot in one case. As regards an additional abnormality; there was hypothyroidism in 38.3%, visual impairment in 6.5%, hearing problems in 5.6%, and undescended testicle in 3.7% of the patients with Down syndrome. Cardiac defects were observed more frequently in patients with hypothyroidism than without hypothyroidism (p<0.05).conclusion: Congenital heart diseases are common in patients with Down syndrome. Even when there are no clinical signs and symptoms, cardiac evaluation of patients with Down syndrome provides early diagnosis and prevents the development of irreversible complications that may arise in the future.

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Thyroid Function in Kuwaiti Subjects with Down’s Syndrome

Cited by 12 publications

References 19 publications

Avaliação etiológica da hipertirotropinemia em crianças com síndrome de Down

Avaliação etiológica da hipertirotropinemia em crianças com síndrome de Down

Etiological assessment of hyperthyrotropinemia in children with Down's syndrome

Clinical and Echocardiographic Evaluation of Children with Down Syndrome

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