Thyroid Function in Early Pregnancy in Japanese Healthy Women: Relation to Urinary Iodine Excretion, Emesis, and Fetal and Child Development

Orito, Yoshiko; Oku, Hisato; Kubota, Sumihisa; Amino, Nobuyuki; Shimogaki, Kayoko; Hata, Mitsutaka; Manki, Kazumi; Tanaka, Yukiko; Sugino, Shoko; Ueta, Michio; Kawakita, Kaori; Nunotani, T; Tatsumi, Nobuya; Ichihara, Kiyoshi; Miyauchi, Akira; Miyake, Megumi

doi:10.1210/jc.2008-2111

Cited by 83 publications

(55 citation statements)

References 29 publications

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“…By contrast, other authors reported that higher newborn T 4 was unexpectedly associated with lower scores on the visual recognition memory test at the age of 6 months but not with scores for verbal abilities, intelligence or visual motor abilities at the age of 3 years (45). Another study observed no neurological impairment in infants aged !1 year born to mothers with elevated TSH during pregnancy (46). Furthermore, neonatal T 4 levels were not associated with the risk of a heterogeneous group of developmental diagnoses in 5-12-year-old children, including attention deficit disorder, autism spectrum disorder, behavioural disorder, cognitive disorder, developmental delay, emotional disorder, learning disability and speech/ language disorder (47).…”

Section: Discussionmentioning

confidence: 89%

Newborn TSH concentration and its association with cognitive development in healthy boys

Freire

Ramos²,

Amaya³

et al. 2010

European Journal of Endocrinology

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Objective: An association between thyroid function during pregnancy or infancy and neurodevelopment in children has been demonstrated. We aimed to investigate whether newborn TSH concentrations are related to subsequent neurocognitive development. Design: We conducted a longitudinal study on 178 children from a general population birth cohort in Granada (Spain) born in [2000][2001][2002]. Methods: TSH concentrations were measured in umbilical cord blood, and cognitive functions were assessed at 4 years of age using the McCarthy's scales of children's abilities (MSCA). Organochlorine (OC) compound concentrations and the combined oestrogenicity (total effective xeno-oestrogenic burden (TEXB)) were also determined in the placentae. Results: Mean newborn TSH was 3.55 mU/l (rangeZ0.24-17 mU/l). In multivariate regression analyses, adjusting for maternal and child characteristics, higher newborn TSH concentrations showed a decrease of 3.51 and 3.15 points on the MSCA general cognitive and executive function scores respectively and were associated with a higher risk of scoring below the 20th percentile (P20) on the quantitative score (odds ratio (OR)Z2.64). Children with TSH in the upper quartile (4.19-17.0 mU/l) were at higher risk of scoring !P20 on span memory (ORZ5.73), whereas children with TSH in the second quartile (2.05-2.95 mU/l) were at lower risk of scoring !P20 on the verbal scale (ORZ0.24). Neonatal TSH status was also associated with general cognitive and executive function outcomes when controlling for prenatal exposure to OCs or placental TEXB. Conclusions: Newborn thyroid hormone status expressed by TSH in cord blood may adversely affect later cognitive function. A more thorough screening for neonatal thyroid deficiency is warranted.

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Section: Discussionmentioning

confidence: 89%

Newborn TSH concentration and its association with cognitive development in healthy boys

Freire

Ramos²,

Amaya³

et al. 2010

European Journal of Endocrinology

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“…169 Excessive iodine intake like in Japan did not affect either the maternal or the off-spring thyroid function. 173 Other studies show an increase in iodine-induced hyperthyroidism in areas with previously low iodine intake and also a higher prevalence of autoimmune thyroiditis (AIT) is discussed. 166 Therefore, it has been suggested to test the thyroid function of women who plan a pregnancy in geographical areas with known iodine deficiency, but this concept is controversial.…”

Section: Iodinementioning

confidence: 94%

Micronutrients in pregnancy: Current knowledge and unresolved questions

et al. 2011

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One-carbon metabolism Pregnancy Liposoluble vitamins Minerals s u m m a r yMicronutrient status is increasingly recognized to play an important role in the health and well-being of pregnant women and in the development and long-term health of the offspring. On 26th e 28th February 2009, The Child Health Foundation invited leading experts in this area to a scientific workshop at Obergurgl, Austria to review and critically discuss current knowledge, to identify issues that may need to be addressed in future recommendations, and to highlight priorities and opportunities for future research. This report summarizes updated key conclusions of the workshop with regards to micronutrients' intake and physiological role related to mother, placenta and fetus, as well as relevance for adverse pregnancy and long-term outcomes.

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“…Zava and Zava 7 estimated that Japanese iodine intake, which comes largely from seaweed consumption, ranges from 1 to 3 mg/day. The mean or median UIC of Japanese residents ranges from 281 to 3300 μg/L in many regions of Japan 8, 9, 10, 11, 12, 13, 14.…”

Section: Introductionmentioning

confidence: 99%

Genetic alterations of differentiated thyroid carcinoma in iodine‐rich and iodine‐deficient countries

et al. 2016

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BRAF V600E mutation, RET rearrangements, and RAS mutations are the common genetic alterations in differentiated thyroid carcinomas derived from follicular thyroid cells. However, the relationship between these alterations and iodine intake is still controversial. To clarify the influence of iodine intake on the occurrence of differentiated thyroid carcinomas, we performed molecular analyses for two differentiated carcinomas, papillary thyroid carcinomas (PTCs) and follicular thyroid carcinomas (FTCs), from an iodine‐rich country (Japan) and an iodine‐deficient country (Vietnam). We examined 120 PTCs (67 Japanese and 53 Vietnamese) and 74 FTCs (51 Japanese and 23 Vietnamese). We carried out allele‐specific polymerase chain reaction (AS‐PCR) for BRAF V600E, PCR and direct sequencing for RAS mutations (codon 12, 13, and 61 in NRAS,HRAS, and KRAS), and RT‐PCR for RET/PTC1 and RET/PTC3. BRAF V600E was present in 55/67 (82.1%) Japanese PTCs and 44/53 (83%) Vietnamese PTCs. RET/PTC1 was identified in only one PTC from each country, and no samples had RET/PTC3. NRAS mutation was found in 17/51 (33.3%) Japanese FTCs and 4/23 (17.4%) Vietnamese FTCs. NRAS mutation was cited in codon 61 (20 cases) and codon 12 (one case). None of FTCs had KRAS or HRAS mutations. There were no significant differences in the prevalence of BRAF V600E,RET/PTC, or RAS mutations between the two countries. Our study showed no differences in genetic alterations of thyroid cancers from iodine‐rich and iodine‐deficient countries, possibly suggesting that iodine intake might not affect the genetic alterations of differentiated thyroid cancer.

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Thyroid Function in Early Pregnancy in Japanese Healthy Women: Relation to Urinary Iodine Excretion, Emesis, and Fetal and Child Development

Abstract: Iodine excess during early pregnancy seems to have no adverse effects on the fetus in healthy Japanese women. To avoid hypothyroidism, reducing excess dietary iodine intake to moderate intake may be beneficial for pregnant woman in Japan.

Cited by 83 publications

References 29 publications

Newborn TSH concentration and its association with cognitive development in healthy boys

Newborn TSH concentration and its association with cognitive development in healthy boys

Micronutrients in pregnancy: Current knowledge and unresolved questions

Genetic alterations of differentiated thyroid carcinoma in iodine‐rich and iodine‐deficient countries

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