Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria

Pisarev, Diana L. Kleiman de; Molina, Marı́a del Carmen; Viale, L

doi:10.1016/0006-2952(90)90195-q

Cited by 46 publications

(27 citation statements)

References 18 publications

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“…HCB and oxychlordane accounted for a minimal proportion (< 3.4%) of the total OC fraction. In an experimental study, Pisarev et al (1990) Article | Effects of contaminants on thyroid hormones in gulls Environmental Health Perspectives • VOLUME 112 | NUMBER 5 | April 2004 Table 2. Results from analyses of covariance (GLM, type III) testing the difference in blood levels of organochlorines (log 10 ng/g ww), plasma levels of thyroid hormones (mol/L) and thyroid ratios (log 10 mole ratio) between two breeding colonies of glaucous gulls (Larus hyperboreus) at Bear Island.…”

Section: Discussionmentioning

confidence: 99%

Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus.

Verreault

Skaare

Jenssen

et al. 2004

Environ Health Perspect

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Studies on glaucous gulls (Larus hyperboreus) breeding in the Barents Sea have reported that high blood levels of halogenated organic contaminants in this species might cause reproductive, behavioral, and developmental stress. However, potential endocrine system modulation caused by contaminant exposure has yet not been reported in this Arctic apical predator. In this present study we aimed to investigate whether the current levels of a selection of organochlorines (OCs) were associated with altered circulating levels of thyroid hormones (THs) in free-ranging adult glaucous gulls breeding at Bear Island in the Barents Sea. Blood concentrations of 14 polychlorinated biphenyls, hexachlorobenzene (HCB), oxychlordane, and p,p´-dichlorodiphenyldichloroethylene (p,p´-DDE) were quantified, in addition to free and total thyroxine (T 4 ) and triiodothyronine (T 3 ), in plasma of 66 glaucous gulls in the spring of 2001. Negative correlations were found between plasma levels of T 4 and T 4 :T 3 ratio, and blood levels of OCs in male glaucous gulls. Despite their relatively low contribution to the total OC fraction, HCB and oxychlordane were the most prominent compounds in terms of their negative effect on the variation of the T 4 :T 3 ratio. Moreover, lower T 4 levels and T 4 :T 3 ratios were measured in glaucous gulls breeding in a colony exposed to high levels of OCs, compared with a less exposed colony. Levels of T 3 were elevated in the high-OC-exposed colony. This may indicate that the glaucous gull is susceptible to changes to TH homeostasis mediated by exposure to halogenated organic contaminants.

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Section: Discussionmentioning

confidence: 99%

Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus.

Verreault

Skaare

Jenssen

et al. 2004

Environ Health Perspect

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“…Although the use of HCB was discontinued in most countries in the 1970s, it is still released into the environment as a byproduct in several industrial processes (Courtney, 1979). Chronic exposure of laboratory animals to HCB elicits a number of harmful effects, such as porphyria, thyroid dysfunctions (Kleiman de Pisarev et al, 1990;Rozman et al, 1986) and cancer (Cabral et al, 1996;Erturk et al, 1986). It is also known to be hepatotoxic, immunotoxic, and has been reported to be a reproductive toxin (Alvarez et al, 2000;Foster et al, 1992).…”

Section: Introductionmentioning

confidence: 95%

The role of type I and type II 5′ deiodinases on hexachlorobenzene-induced alteration of the hormonal thyroid status

et al. 2005

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“…HCB is one of initial 12 Persistent Organic Pollutants (Jones and Voogt, 1999), and it can cause a wide range of toxic effects including cancer in animals (Erturk et al, 1986;Cabral et al, 1996), hepatotoxicity (Foster et al, 1992;Alvarez et al, 2000) and porphyria (Rozman et al, 1986;Kleiman de Pisarev et al, 1990) both in humans and animals. The commercial production of HCB was banned in Europe and the USA, but it continues to be produced as a byproduct during manufacturing of some solvents and pesticides (Bailey, 2001;Barber et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Aerobic biodegradation of hexachlorobenzene by an acclimated microbial community

Liu

Chen

Shen

2009

IJEP

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Abstract:The aerobic degradation of hexachlorobenzene (HCB) by an acclimated microbial community which isolated from a contaminated site and acclimated in our laboratory was investigated. The enriched microbial community was capable of biodegrading HCB when cultivated in minimal salts medium and supplied HCB as the sole carbon source. The efficiencies of microbial community in the degradation of HCB under different pH and temperatures were examined. The phylogenetic analysis for the nearly complete sequences of 16S rDNA demonstrated that the bacteria assemblage in the microbial community was dominated by Azospirillum and Alcaligenes groups.

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Thyroid function and thyroxine metabolism in hexachlorobenzene-induced porphyria

Cited by 46 publications

References 18 publications

Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus.

Effects of organochlorine contaminants on thyroid hormone levels in Arctic breeding glaucous gulls, Larus hyperboreus.

The role of type I and type II 5′ deiodinases on hexachlorobenzene-induced alteration of the hormonal thyroid status

Aerobic biodegradation of hexachlorobenzene by an acclimated microbial community

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