Thyroid Function Abnormalities and Outcomes in Hospitalized Patients
                    with COVID-19 Infection: A Cross-Sectional Study

Patel, Deepika; Naik, Dukhabandhu; Kamalanathan, Sadishkumar; Kadhiravan, Tamilarasu; Sahoo, Jayaprakash; Roy, Ayan; Merugu, Chandhana; Suryadevara, Varun

doi:10.1055/a-2014-4634

Cited by 4 publications

(3 citation statements)

References 55 publications

(106 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study showed that more than one-third of patients with COVID-19 infection can have abnormal thyroid function test (TFT), more so in those with severe illness. The most common thyroid function abnormality was a sick euthyroid syndrome, irrespective of thyroid autoantibody status [22].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Gland Dysfunction and COVID-19 Severity: Is There a Correlation?

El Khatib,

Sharabi-Nov,

Farhat

et al. 2023

J Endocrinol Metab

View full text Add to dashboard Cite

Background:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the coronavirus pandemic to break out in 2019 has resulted in a serious health disaster all over the world. It has been suggested that thyroid gland dysfunction in coronavirus disease 2019 (COVID-19) patients can directly or indirectly affect COVID-19 severity and mortality rates. The aim of this study was to examine the possible effect of thyroid dysfunction on the severity and mortality in COVID-19 hospitalized patients.Methods: This is a retrospective study that included 415 COVID-19 patients, who were admitted to the Ziv Medical Center between April 2020 and October 2021. Clinical and demographic data were collected from patient's electronic medical records. Results:Patients with severe COVID-19 disease hospitalized in COVID-19 intensive care unit (ICU) department had significantly lower average level of triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) levels compared with patients with mild or moderate disease in hospitalized patients in COVID-19 ward. Regarding hospitalization length, there was a statistically significant difference between the two groups with a mean of 14.6 days for COVID-19 ICU department and 8.6 days for the COVID-19 ward (P < 0.001). Similarly, the mortality rate also showed a significant difference, with 48.8% in COVID-19 ICU department compared to 10.4% in the COVID-19 ward (P < 0.001). However, it is worth noting that ethnicity, gender, body mass index (BMI), and chronic diseases did not exhibit any significant differences between the two groups. In a multivariate logistic regression model the risk of mortality was three times higher among patients with lowered T4 levels and six times higher among patients with lower TSH levels. Longer duration of hospitalization (odds ratio (OR) = 1.12) and older age (OR = 1.07) were also associated with higher mortality, while T3 was inversely associated (OR = 0.07). Conclusions:It was suggested that lower thyroid hormones and TSH serum levels were associated with increased severity and mortality in COVID-19 hospitalized patients. Thyroid hormones and TSH levels may serve as additional tools for better evaluation of COVID-19 severity and mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Thyroid Gland Dysfunction and COVID-19 Severity: Is There a Correlation?

El Khatib,

Sharabi-Nov,

Farhat

et al. 2023

J Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…Patients were classified into different thyroid disorders, such as subclinical hypothyroidism, overt hypothyroidism, thyrotoxicosis, and non-thyroid illness, described in detail in the previous publication [46].…”

Section: Thyroid Functionmentioning

confidence: 99%

Male Hypogonadism After Recovery from Acute COVID-19 Infection: A Prospective Observational Study

Prasad,

Rashmi,

Sahoo

et al. 2023

Exp Clin Endocrinol Diabetes

Self Cite

View full text Add to dashboard Cite

Background The severe acute respiratory syndrome coronavirus 2 can affect the hypothalamic-pituitary-gonadal axis (HPG) due to the expression of the angiotensin-converting enzyme 2 receptor. Objectives To assess the prevalence of hypogonadism and Sertoli cell dysfunction in coronavirus disease 2019 (COVID-19) male survivors. Method Male subjects recovered from acute COVID-19 infection were prospectively observed. The primary outcomes included the proportion of hypogonadism, defined biochemically as serum testosterone<230 ng/dL or CFT of<6.4 ng/mL if the total testosterone is between 230–320 ng/m. Sertoli cell dysfunction was defined as inhibin-B level<54.5 pg/mL. Subjects with hypogonadism were followed up at 12 months to assess the recovery of the HPG axis. Results Eighty-three subjects aged≥18 years were evaluated at a median of 120 (±35) days post-recovery. Their mean age was 49.50±12.73 years, and the mean BMI was 26.84±5.62 kg/m2. Low testosterone was detected in 21 (24.71%) and low inhibin-B was detected in 14 (19.71%) out of 71 subjects at 3 months. Subjects with low testosterone were younger, with a mean age of 43.29±12.03 years (P-0.08) and higher BMI (P-0.012). The severity of COVID-19 infection, duration of hospitalization, and other factors were not significantly associated with low testosterone. At 12 months, 18 out of 21 subjects came for follow-up, of which 9 (50%) showed persistently low testosterone, suggestive of hypogonadism. Conclusion Following COVID-19 infection, testosterone levels recovered over time; however, a significant proportion of subjects had low levels at 12-month follow-up. These findings have long-term implications for the management of COVID-19 subjects.

show abstract

“…The effect of thyroid hormone supplementation on poor clinical outcomes for low thyroid hormone levels in critically ill patients is unknown. The clinical benefit of thyroid hormone supplementation has not been fully demonstrated 7,8 . On the contrary, some studies have reported that TH concentrations are not associated with clinical outcomes 9,10 .…”

Section: Introductionmentioning

confidence: 99%

A new marker in determining the relationship between the clinical outcomes of patients with sepsis and thyroid function tests: free triiodothyronine to free thyroxine ratio

YAKIŞIK,

YÜCEL,

KIZILGÜN

et al. 2023

Cukurova Medical Journal

View full text Add to dashboard Cite

Purpose: This study investigated the predictive value of thyroid hormones in septic patients. Materials and Methods: Our study was conducted in patients with sepsis in intensive care unit (ICU). Free triiodothyronine (fT3) and free thyroxine (fT4) levels taken at the time of hospitalization and at the 48th hours were measured and the fT3 / fT4 ratio was calculated. Calculated fT3 and fT4 change between first and 48th hours. Results: 192 patients with sepsis were included in the study. In non-survivor patients, first fT3 (1.60±0.57 ng/dL v.s. 2.01±0.41 ng/dL) and fT3 / fT4 ratio (1.34±0.88 v.s. 1.79±0.91) were found to be significantly lower than 48th hours fT3 (0.77±0.39 ng/dL v.s. 1.87±0.49 ng/dL) and fT3 / fT4 ratio (0.60±0.51 v.s. 1.66±1.21) survivors. It was found that the first fT3 levels (-0.83±0.45 v.s. -0.23±0.14) and fT3 / fT4 ratio (-0.73±0.62 v.s. -0.12±0.11) decreased significantly more at 48th hour in non-survivors than survivors. The 48th hours fT3 level and the change in fT3 between the first and 48th hour were found to be the most significant parameters for the mortality indicator. Conclusion: fT3 / fT4 ratio has predictive value for mortality in patients with sepsis in ICU. In addition, fT3 was found to be an indicator for mortality predictivity both at admission and at 48th hours.

show abstract

Thyroid Function Abnormalities and Outcomes in Hospitalized Patients with COVID-19 Infection: A Cross-Sectional Study

Cited by 4 publications

References 55 publications

Thyroid Gland Dysfunction and COVID-19 Severity: Is There a Correlation?

Thyroid Gland Dysfunction and COVID-19 Severity: Is There a Correlation?

Male Hypogonadism After Recovery from Acute COVID-19 Infection: A Prospective Observational Study

A new marker in determining the relationship between the clinical outcomes of patients with sepsis and thyroid function tests: free triiodothyronine to free thyroxine ratio

Contact Info

Product

Resources

About