Thyroid Follicular Epithelial Cell-Derived Carcinomas: An Overview of the Pathology of Primary and Recurrent Disease

Todd, William U.; Wenig, Bruce M.

doi:10.1016/j.otc.2008.08.001

Cited by 5 publications

(1 citation statement)

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“…We also confirmed that the markers known to participate in transformation including p53, Ki-67, and others were not initially expressed but were expressed at the full anaplastic transformation. Todd and Wenig7 reported that thyroglobulin and TTF-1 immunoreactivity was completely reduced in recurrent or metastatic thyroid carcinoma and anaplastic thyroid carcinoma, which showed less differentiated histologic features, and these results were identical to the immunostaining results of our case. Ozaki et al8 reported that high Ki-67 expression was found in more malignant tumors, which was also similar to the findings in our case.…”

Section: Discussionsupporting

confidence: 89%

Anaplastic Transformation of Papillary Thyroid Carcinoma in a Young Man: A Case Study with Immunohistochemical andBRAFAnalysis

et al. 2014

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This study reports a case of anaplastic transformation from a well-differentiated thyroid carcinoma in a young patient. The first recurrent tissue contained poorly differentiated foci that revealed lower thyroglobulin, thyroid transcription factor 1 (TTF-1), and galectin-3 expression than the well-differentiated area. However there was no increased p53 or Ki-67 expression in the poorly differentiated foci, nor in the well-differentiated area. The tissue subsequently relapsed and revealed only anaplastic features, complete loss of thyroglobulin, TTF-1, and galectin-3 expression and revealed an increase in p53 and Ki-67 expression. The BRAF V600E and BRAF V600V mutation were found in the initially diagnosed papillary thyroid carcinoma and the poorly differentiated foci of the recurring papillary thyroid carcinoma; however, only the BRAF V600V mutation was found in the anaplastic carcinoma. These results suggest that overexpression of p53 and Ki-67 contributed to the anaplastic transformation. We also found that the BRAF type changed during the tumor relapse.

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Section: Discussionsupporting

confidence: 89%