Thyroid endocrine system disruption by pentachlorophenol: An in vitro and in vivo assay

Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio)

“…Previous reports indicated possible thyroid disrupting effects on animals after exposure to PCP by regulation of HPT axis-related genes expression Guo and Zhou, 2013;Hughes et al, 1985;Jekat et al, 1994;Yu et al, 2014), but this is the first report showing similar thyroid disrupting effects after PCA exposure. Our results show that PCA can also affect gene expression related to thyroid hormone regulation similar to PCP.…”

Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines

“…FRTL-5 is a rat thyroid follicular cell line that is typically used to determine changes in iodide uptake (Arturi et al, 2002;LecatGuillet and Ambroise, 2008;Weiss et al, 1984). Recently, gene expression analysis has been applied to these cell lines to understand the toxicity of environmental chemicals (Gentilcore et al, 2013;Guo and Zhou, 2013). In addition to these cell lines, zebrafish embryos/larvae were also used in the present study in order to determine the in vivo response to TPP exposure during this sensitive stage of life.…”

Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae

“…As a consequence, PCP has resulted in widespread environmental contamination in the local water environment where PCP has been detected in surface waters in China (up to 1.15 g/L) [20,25]. A high PCP concentration has been detected in Dongting Lake (up to 103.7 g/L), which is attributed to its application for the control of snailborne schistosomiasis [26][27][28]. Previous studies indicate that principal mechanisms of action of PCP-induced toxicity seem to be related to the uncoupling of oxidative phosphorylation in mitochondria and the generation of reactive oxygen species (ROS) [17,29].…”