Thyroid endocrine disruption and external body morphology of Zebrafish

Sharma, Prakash; Grabowski, Timothy B.; Patiño, Reynaldo

doi:10.1016/j.ygcen.2015.12.023

Cited by 30 publications

(16 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The up-regulating role of exogenous thyroxin on the growth and metamorphosis of flatfish is well-recognized (Yoo et al, 2000;Yamano, 2005). Whereas, the larval growth suppression was reported for some fish larvae under the goitrogenic effect (Goleman et al, 2002;Crane et al, 2005;Yamano, 2005;Sharma et al, 2016).Thyroid hormones are included in regulating the growth of fish and larvae, by directly or indirectly stimulation of growth hormone or insulin-like growth factors (Deane et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, thyroid hyperplasia is very likely to have resulted from a hypothyroidism that take place during study period and hence stimulating release of TSH by negative feedback on the pituitary, followed by thyroid follicles stimulation for T4 production (Eales and Brown 1993). The goitrogen (perchlorate) disrupts the thyroid follicles structure in some studied fish as for fathead minnow, Pimephales promelas (Crane et al, 2005), zebrafish (Van der Ven et al, 2006;Sharma et al, 2016) and threespine stickleback (Petersen et al, 2015). Studies demonstrated that thyrocyte height and thyroid follicle morphology could be consistent markers of goitrogen effects in fish over the contradictory outcome of TH levels (Schmidt and Braunbeck, 2011).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Involvement of thyroid hormone in the intestine and liver development of the common sole (Solea solea L.) larvae

Ismail¹

2018

Egypt. J. of Aquatic Biolo. and Fish.

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Involvement of thyroid hormone in the intestine and liver development of the common sole (Solea solea L.) larvae

Ismail¹

2018

Egypt. J. of Aquatic Biolo. and Fish.

View full text Add to dashboard Cite

“…For instance, the molecular mechanisms of thyroid organogenesis and the role of TR signaling during embryogenesis are well documented for zebrafish and seem to be highly conserved between zebrafish and mammalian models [26,31]. (Neuro)developmental processes that are, at least partially, regulated by THs include eye development, swim bladder inflation and fin formation during early embryonic development and the metamorphosis from the larval to juvenile stage [33][34][35][36][37]. Exposure to THDs has been shown to affect these important developmental processes, which makes them promising candidates for thyroid-related endpoints in THD fish testing assays.…”

Section: Conceptmentioning

confidence: 99%

“…Exposure to THDs has been shown to affect these important developmental processes, which makes them promising candidates for thyroid-related endpoints in THD fish testing assays. For instance, inhibited differentiation of paired fins was observed in zebrafish exposed to different THDs during the transition from larval to juvenile stage [37]. Moreover, eye development and the resulting visual performance were demonstrated to be disturbed by disruption of the thyroid system with different THDs or thyroid-specific gene-knockouts [33,36,[38][39][40][41].…”

Section: Conceptmentioning

confidence: 99%

ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

Holbech

Matthiessen²,

Hansen

et al. 2020

IJMS

View full text Add to dashboard Cite

ERGO (EndocRine Guideline Optimization) is the acronym of a European Union-funded research and innovation action, that aims to break down the wall between mammalian and non-mammalian vertebrate regulatory testing of endocrine disruptors (EDs), by identifying, developing and aligning thyroid-related biomarkers and endpoints (B/E) for the linkage of effects between vertebrate classes. To achieve this, an adverse outcome pathway (AOP) network covering various modes of thyroid hormone disruption (THD) in multiple vertebrate classes will be developed. The AOP development will be based on existing and new data from in vitro and in vivo experiments with fish, amphibians and mammals, using a battery of different THDs. This will provide the scientifically plausible and evidence-based foundation for the selection of B/E and assays in lower vertebrates, predictive of human health outcomes. These assays will be prioritized for validation at OECD (Organization for Economic Cooperation and Development) level. ERGO will re-think ED testing strategies from in silico methods to in vivo testing and develop, optimize and validate existing in vivo and early life-stage OECD guidelines, as well as new in vitro protocols for THD. This strategy will reduce requirements for animal testing by preventing duplication of testing in mammals and non-mammalian vertebrates and increase the screening capacity to enable more chemicals to be tested for ED properties.

show abstract

“…EDs can disrupt the endocrine system through different mechanisms [ 7 , 8 , 9 , 10 , 11 , 12 ]. One of the well-known mechanisms is mediated by the hormone receptors such estrogen receptor (ER) and androgen receptor (AR), in which EDs exhibit their estrogenic and androgenic effects through binding to the ER and AR in the target cells [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals

Hong

Shen

et al. 2016

IJERPH

View full text Add to dashboard Cite

Endocrine disruptors such as polychlorinated biphenyls (PCBs), diethylstilbestrol (DES) and dichlorodiphenyltrichloroethane (DDT) are agents that interfere with the endocrine system and cause adverse health effects. Huge public health concern about endocrine disruptors has arisen. One of the mechanisms of endocrine disruption is through binding of endocrine disruptors with the hormone receptors in the target cells. Entrance of endocrine disruptors into target cells is the precondition of endocrine disruption. The binding capability of a chemical with proteins in the blood affects its entrance into the target cells and, thus, is very informative for the assessment of potential endocrine disruption of chemicals. α-fetoprotein is one of the major serum proteins that binds to a variety of chemicals such as estrogens. To better facilitate assessment of endocrine disruption of environmental chemicals, we developed a model for α-fetoprotein binding activity prediction using the novel pattern recognition method (Decision Forest) and the molecular descriptors calculated from two-dimensional structures by Mold2 software. The predictive capability of the model has been evaluated through internal validation using 125 training chemicals (average balanced accuracy of 69%) and external validations using 22 chemicals (balanced accuracy of 71%). Prediction confidence analysis revealed the model performed much better at high prediction confidence. Our results indicate that the model is useful (when predictions are in high confidence) in endocrine disruption risk assessment of environmental chemicals though improvement by increasing number of training chemicals is needed.

show abstract

Thyroid endocrine disruption and external body morphology of Zebrafish

Cited by 30 publications

References 32 publications

Involvement of thyroid hormone in the intestine and liver development of the common sole (Solea solea L.) larvae

Involvement of thyroid hormone in the intestine and liver development of the common sole (Solea solea L.) larvae

ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters

A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals

Contact Info

Product

Resources

About