Thyroid dysfunctions in patients with chronic renal failure

Pakhle, Ketan; Parikh, Rushab; Jain, Ashwini; Kashyap, Prashant; Dave, Dhaval; Bhate, Archana

doi:10.18203/2320-6012.ijrms20172485

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…According to our study, in patients with low T3 syndrome, the mean values of TSH in various stages of renal disease are within normal range, values of TSH did not show any linear correlation with GFR. These results correlate with the studies by Pakhle et al, 11 where there was a positive significant correlation was found between the levels of serum creatinine with levels of T3 and TSH.…”

supporting

confidence: 92%

“…Excluding 12 hypothyroid patients who have low T4 values, 24 other patients counting to 44% had T4 level below normal and low T3 syndrome (Table 4) In our study the blood urea varied from 64 -177 mg/dl and creatinine levels varied from 3mg -17.2mg/dl, 24 hours urine protein excretion was <1g/day in all the patients. Our results correlated with the other studies conducted by Pakhle et al, 11 were the mean serum creatinine and blood urea levels in the patients were reported to be 6.17±0.78 mg/dl and 94.92±14.36 mg/dl respectively; and Shamsuddin et al 2014, 15 reported mean serum creatinine levels of 5.83±0.69 mg/dl and that of blood urea was reported to be 96.23±12.24 mg/dl. The results were more or less similar to present study suggesting severe kidney dysfunction.…”

supporting

confidence: 92%

“…The observations of this survey have also been authenticated throughout the developed world countries such as Asia, Europe, and Australia as well as in developing regions such as India, China and Africa. 10,11 Patients with CKD have many signs and symptoms suggestive of thyroid dysfunction like sallow complexion, edema, dry skin, cold intolerance, decreased BMR, asthenia and hyporeflexia is reported in patient with CKD. So even the slightest change in the prognosis in the CKD levels, it is difficult to exclude thyroid dysfunction on mere clinical background.…”

Section: Introductionmentioning

confidence: 99%

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A Prospective Study on the Evaluation of Thyroid Function Status in Patients with Chronic Kidney Disease

Benjamin¹

2017

JMSCR

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supporting

confidence: 92%

supporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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A Prospective Study on the Evaluation of Thyroid Function Status in Patients with Chronic Kidney Disease

Benjamin¹

2017

JMSCR

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“…Many studies on thyroid hormone levels in CRF have revealed variable results. Overall prevalence of thyroid dysfunction was reported as 48%, 38.6% and 58% by Pakhle K et al, 10 Khatiwada S et al 11 and Manasa A.S. Gowda et al 12 respectively as compared to 60% in our study. 9.5% of patients with CKD had subclinical hypothyroidism.…”

Section: Discussioncontrasting

confidence: 41%

A Study of Biochemical Abnormalities of Thyroid Function Test in Chronic Renal Failure Patients

Nayak¹,

Chaudhari²

2020

jebmh

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BACKGROUND Chronic renal failure is a progressive decline in renal function with loss of nephrons leading to signs and symptoms of uraemia. CRF affects endocrine systems in multiple ways including abnormal hormone production, metabolism, feedback regulation and altered tissue sensitivity. Thyroid hormones are essential for an adequate growth and development of kidneys; conversely, kidney is not only an organ of metabolism and elimination of thyroid hormones, but also a target of iodothyronine actions. Renal disease leads to significant changes in thyroid function. In CRF, iodide uptake is low due to decreased iodide clearance. Protein loss may alter the binding capacity of hormones and abnormal constituents like urea may blunt the tissue responsiveness to thyroid hormones. The association of different glomerulopathies less frequently tubulointerstitial diseases have been reported with hypo or hyper function of the thyroid. METHODS Patients with chronic kidney disease in Department of Medicine and Nephrology, Down Town Hospital, Guwahati, Assam, were included in the study. Both male and female patients with varying grades of CRF, more than 18 years of age were included in the study. It was cross sectional study. RESULTS Age range in the study varies from 27-87 years. Male patients were 30 accounting for 60% and female patients were 20 accounting for 40%. Creatinine clearance ranges from 3.4 mL/min-32.3 mL/min. Blood urea values varied from 55-257 mg/dL, the mean being 121.04. Serum creatinine levels varied from 1.8-21.16 mg/dL, the mean value being 7.58 mg/dL. The study range of serum T3 was 0.643-2.3 nmol/L, (normal range 1.49-2.60 nmol/L), serum T4 was 37.7-140 nmol/L (normal range 71.2-142 nmol/L) and serum TSH was <0.015->100 micro IU/mL (normal range 0.465-4.68 mIU/mL). In our study 10 patients had low T3 syndrome, 2 patients had low T4 Syndrome, 9 patients had hypothyroidism, 8 patients had subclinical hypothyroidism and 1 patient had hyperthyroidism. CONCLUSIONS In the current study 50 cases with varying grades of chronic renal failure with age >18 years are selected according to inclusion and exclusion criteria as mentioned. The present study is limited in the sense that data comes from a population served in a tertiary healthcare hospital. Therefore, it's not a population-based study. However, the findings of this study will serve to analyse the association between thyroid dysfunction, if any, in chronic renal failure patients.

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Evaluation of Serum Iron Status and Thyroid Profile in Patients of Chronic Kidney Disease

P.Srirekha

Rani

et al. 2022

ijsr

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OBJECTIVE: To nd the prevalence and association of thyroid dysfunction with anemia/body iron status among Chronic kidney disease patients, MATERIALS AND METHODS:It is a cross-sectional study conducted in Government General Hospital ,Kurnool during the period from jan 2021-july 2021.. Atotal of 75 patients were included in our study who satised the diagnostic criteria of CKD and patients underwent clinical and renal parameters, haematological prole and iron status. For comparison of the results with the general population adequate number of controls were taken . RESULTS: Our study results showed that out of the 75 patients with CKD 49 patients had low T3 syndrome which accounts for 65% of the patients, 14 patients had low T4 syndrome) which accounts for 18% of the patients and 12 patients had primary hypothyroidism TSH >20µIU/ml. it was found that nearly 43% of the patients did not have target serum ferritin of 100 ng/ml and 49.2% of study population did not have target TSATof >20%. CONCLUSION: The study demonstrates a high prevalence of thyroid abnormalities particularly hypothyroidism, accompanied by increased prevalence of anemia and iron deciency indicating symbiotic relationship between thyroid gland function and body iron status. Thyroid Dysfunction occurred in the patients with chronic kidney disease, it does not indicate a state of hypothyroidism, but a reection of the state of chronic illness/malnutrition.

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Thyroid dysfunctions in patients with chronic renal failure

Cited by 3 publications

References 5 publications

A Prospective Study on the Evaluation of Thyroid Function Status in Patients with Chronic Kidney Disease

A Prospective Study on the Evaluation of Thyroid Function Status in Patients with Chronic Kidney Disease

A Study of Biochemical Abnormalities of Thyroid Function Test in Chronic Renal Failure Patients

Evaluation of Serum Iron Status and Thyroid Profile in Patients of Chronic Kidney Disease

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