Thyroid dysfunction in patients of chronic kidney disease

Gupta, Abhishek; Kuldeep, K; Virmani, S. K.; Arora, Mandeep Kumar

doi:10.18203/2349-3933.ijam20174189

Cited by 4 publications

(2 citation statements)

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“…Various abnormalities in thyroid hormone levels and metabolism have been described in people with this condition. 2,3 In recent years, a worldwide increase in chronic kidney disease (CKD) has placed a significant burden on the healthcare system in this region of the world. Concerns also surround thyroid dysfunction in CKD.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Hormone Profile in Chronic Kidney Disease Patients Handled Conservatively or by Haemodialysis

Retash Shan,

Suman K. Kotwal,

Mrityunjay Gupta

et al. 2022

IJPHRD

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Background: There is an interdependency between thyroid hormones and renal function. Chronic Kidney Disease (CKD) is a degradation of renal function that is irreversible. Aimsand Objectives:To compare the thyroid hormone profiles of CKD patients receiving two distinct therapeutic approaches. Materials and methods:Over the course of one year, 200 newly diagnosed or known patients withCKD were recruited for a cross-sectional study. Group 1 consisted of 100 CKD patients treated conservatively, whereas Group 2 consisted of 100 CKD patients on haemodialysis. Fasting Blood Glucose (FBG), Serum urea (S. Urea), Serum Creatinine (S. Creatinine), and a thyroid hormone profile were all measured. Estimated Glomerular Filtration Rate (eGFR) was calculated using the Cockcroft-Gault formula. Results:The mean age of patients in Group 1 was 51.04 years and in Group 2 it was 53.20 years. S. Creatinine, S. Urea, and eGFR values changed significantly between the two treatment groups. In 36% of instances, a thyroid malfunction was present. Only FT4 differed significantly across the two groups (p = 0.026)Conclusion:Low levels of the thyroid hormones FT3, FT4, TT3, and TT4 were detected in all CKD cases. However, no significant differences in thyroid status were found between haemodialysis patients and non-dialysis patients.

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Section: Introductionmentioning

confidence: 99%

Thyroid Hormone Profile in Chronic Kidney Disease Patients Handled Conservatively or by Haemodialysis

Retash Shan,

Suman K. Kotwal,

Mrityunjay Gupta

et al. 2022

IJPHRD

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“…Both thyroid hormones and kidney functions have a multifaceted mutual interdependence [4] (List 1). Thyroid hormones play an important role in regulating the basal metabolic rate, development, protein synthesis and it also influences the function of some other hormones [5]. In the kidney, thyroid hormones play a significant role in its growth and development and for the maintenance of water and electrolytes.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Function Test in Patients with Chronic Kidney Disease

Abhinaya

Kumar

2021

JPRI

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Background: Kidneys have a significant role in the metabolism, degradation and excretion of thyroid hormones. Both thyroid hormones and kidney functions have a multifaceted mutual interdependence. Objectives: To find out the possible association between the severity of chronic kidney disease and thyroid dysfunction; To estimate the correlation between thyroid dysfunction and various stages of chronic kidney disease. Materials and Methods: A prospective Cross-sectional study was done on 50 patients with Chronic kidney disease who were not on dialysis and fulfilled all the inclusion criteria at Saveetha medical college over a period of 6 months. Free T3, Free T4 and TSH levels were estimated for those patients. Results: Results of this study showed that majority of subjects included in our study were in the age group of 50-60 years with Male predominance. Out of 50 patients included in our study, 8 patients(16%) were found to hypothyroidism; 5 patients (10%) were having subclinical hypothyroidism; 20 patients (40%) were having low T3 syndrome and 17 patients (34%) were having normal functioning thyroid gland. Staging of CKD was done in relation to the glomerular filtration rate .Most of the patients(n=20) were in Stage 5 of Chronic kidney disease out of which 18 patients were having thyroid disorders. Conclusion: There is a positive correlation between the severity of CKD and thyroid dysfunction. Hence a routine thyroid function status should be evaluated in each and every patient of CKD to reduce the morbidity and mortality rate of CKD patients as well as reduce the social burden and health expenditure.

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A Study of Thyroid Hormone Patterns in Chronic Kidney Disease

Madhav

Edupuganti

2022

ijsr

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Background: Kidneys have a prominent role in the metabolism, degradation and excretion of thyroid hormones. There is an increased prevalence of hypothyroidism in chronic kidney disease (CKD) patients as the glomerular ltration rate falls. T Objectives: o study the thyroid function in chronic kidney disease patients and to study the correlation of thyroid dysfunction with respect to staging of CKD. A Materials and Methods: prospective Cross-sectional study was done on 100 patients with Chronic kidney disease who were not on dialysis and fullled all the inclusion criteria at Dr PSIMS & RF. Total and Free T3, T4 and TSH levels were estimated for those patients. Majority of subjects included in our Results: study were in the age group of 60-69 years with male predominance. Out of 100 patients included in our study, 50 patients(50%) were found to have low T3 syndrome; 6 patients (6%) were having hypothyroidism; 44 patients (44%) were having normal thyroid gland function. Most of the patients (n=58) were in stage 5 of Chronic kidney disease. In the present study, as creatinine clearance reduced with each CKD stage, the levels of total T3 and free T4 were also reduced. There is a positive correlation between the Conclusion: severity of CKD and thyroid dysfunction. Hence by studying the incidence of thyroid dysfunction in CKD patients and their subsequent treatment, it may help in slowing the progression of CKD.

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Thyroid dysfunction in patients of chronic kidney disease

Cited by 4 publications

References 10 publications

Thyroid Hormone Profile in Chronic Kidney Disease Patients Handled Conservatively or by Haemodialysis

Thyroid Hormone Profile in Chronic Kidney Disease Patients Handled Conservatively or by Haemodialysis

Thyroid Function Test in Patients with Chronic Kidney Disease

A Study of Thyroid Hormone Patterns in Chronic Kidney Disease

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