Thyroid disorders in pregnancy

Abstract

Thyroid disease is the second most common endocrine disorder encountered in pregnant women with substantial maternal and fetal implications. Therefore, assessing thyroid status during pregnancy is essential for initiating treatment in newly diagnosed individuals and adjusting doses for those already under treatment. To initiate proper and timely treatment evidence-based recommendations are required for clinical decisionmaking in managing thyroid disorders in pregnant and postpartum women. Keeping this in mind, task force consisted of experts in the fields of endocrinology and thyroid disease was constituted and various published data and guidelines were explored to address screening, diagnosis, and management of hypothyroidism, thyrotoxicosis, GD, thyroid nodules, and post-partum thyroiditis and their related complications during pregnancy. This document provides much-required insights and useful, practical, and accurate guidance that aids a practicing clinician.

Third-generation Thyrotropin Receptor Antibody (Trab) Assay for Predicting Neonatal Thyroid Dysfunction in Pregnant Women With Graves’ Disease

“…Inclusion criteria was all pregnant women with Graves' disease diagnosed either before or during pregnancy, with positive TRAB levels. Graves' disease was diagnosed based on symptoms and signs of hyperthyroidism, including diffuse goiter and/or Graves' ophthalmopathy with or without dermopathy along with suppressed pregnancy trimester speci c thyroid stimulating hormone (TSH), high total thyroxine (TT4) or free thyroxine (FT4) and positive TRAB levels 12 . Exclusion criteria were hyperthyroidism other than Graves' disease as well as not consenting for study.All the pregnant women who were on propylthiouracil during rst trimester were converted into equivalent doses of carbimazole in the second and third trimester on aiming to keep FT4 at high normal levels.…”