Thyroid Disorders in Korean Patients with Systemic Lupus Erythematosus

Abstract

Although autoimmune thyroid diseases have been associated with systemic lupus erythematosus (SLE), the prevalence of thyroid disorder is controversial. To clarify the prevalence of thyroid disorder in Korean patients with SLE, thyroid functions and diseases were evaluated in 63 SLE patients. Of these patients, Hashimoto's thyroiditis (9.5%) as well as euthyroid sick syndrome (14.3%) were more common than Graves' disease (4.8%). The prevalence of antithyroid autoantibodies (antimicrosomal and/or antithyroglobulin autoantibodies) in SLE was 27.0%. High titers of these autoantibodies were mainly detected in Hashimoto's thyroiditis. These results suggested that thyroid diseases are not uncommon in SLE and autoimmune thyroid diseases are possible manifestations in some patients with SLE. Antithyroid autoantibodies may be good predictors for the detection of Hashimoto's thyroiditis developing in SLE.

The spectrum of thyroid disorders in systemic lupus erythematosus

“…In agreement with most other studies [5,7,8], primary hypothyroidism (14%) and subclinical hypothyroidism (12%) were the most common alterations among our SLE patients, which was significantly higher when compared to control group (5 and 3%, respectively). A much higher prevalence of hypothyroidism in our lupus patients when compared to lupus cohort of other studies (Table 1) may be attributed to higher prevalence of thyroid disorders in Asians than western population with SLE further raising the risk over and above the ethnic predisposition.…”

“…Thyroid being one of the common target of autoimmune process, its association with SLE, a systemic autoimmune disease is likely. Autoimmune thyroid disease, marked by the presence of antibodies directed against thyroid antigens, has been associated with a number of non-organ-specific rheumatologic disorders like systemic lupus erythematosus [5][6][7][8][9][10], Sjögren's syndrome [12], rheumatoid arthritis [10] and giant cell arteritis [13].…”

Insuffisance thyroidienne hypothyréotrope transitoire lors d'une crise de goutte

“…L'effet évoqué se situe aussi bien au niveau central (hypophyse) que périphérique (thyroïde, foie, rein, etc). Les NTIS d'une durée plus importante peuvent quant à eux être dus à une véritable hypothyroïdie centrale transitoire [4]. Notre cas présente trois particularités.…”

Presença de auto-anticorpos não-tireóide-específicos no soro de pacientes com hipotireoidismo auto-imune

“…Ressaltamos, contudo, que a associação entre doenças auto-imunes da tireóide e outras doenças auto-imunes é fato incontestável (5,20), podendo ocorrer em qualquer período no curso de sua evolução. Portanto avaliações regulares são recomendadas.…”

“…As Dait ocorrem no curso de várias outras doenças autoimunes, e anticorpos antitireoidianos apresentam-se em várias destas doenças (3,4,7,22,24), inclusive as não-órgão-específicas como lúpus eritematoso sistêmico (LES) e síndrome de Sjögren (5,14,20,21).…”