Thyroid carcinoma in the United Arab Emirates: perspectives and experience of a tertiary care hospital

Al-Zaher, Nabil; Al-Salam, Suhail; Teraifi, Hassan El

doi:10.1016/s1658-3876(08)50055-0

Cited by 32 publications

(36 citation statements)

References 29 publications

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“…Similarly, it is ranked the third most common among Kuwaiti women and second most common among Saudi women 12 . The female predominance observed in this study is similar to those of the previous studies from KSA, UAE, Yemen, Kuwait, Poland, Togo, Turkey, and Brazil 7,9,10,[13][14][15][16][17] . In contrast, thyroid cancer is the 16th most common among females in Ireland 18 .…”

Section: Discussionsupporting

confidence: 91%

Thyroid Surgeries in a Single Centre, 2010 - 2014

Khuzaie¹,

Kamal²,

Alboosta³

2018

BMB

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Background: Thyroid surgery is the preferred modality of treatment in malignant and benign thyroid disease including papillary thyroid cancer and multinodular goiter. Objective: To describe the epidemiology of surgically treated thyroid disease in a single center, the cytological and histological patterns and assess the sensitivity and specificity of fine-needle aspiration cytology (FNAC) in diagnosing thyroid nodules with malignant potentials. Design: A Retrospective Study.

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Section: Discussionsupporting

confidence: 91%

Thyroid Surgeries in a Single Centre, 2010 - 2014

Khuzaie¹,

Kamal²,

Alboosta³

2018

BMB

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“…We believe that this difference in the age pattern of BRAF V600E mutation is mainly due to the differences in patients samples between ours and these studies; as most of our PTC samples (70%) are from patients with ages younger than 55 years (Fig 2). In addition, a previous study in the UAE [16] have also shown more than three quarters of PTC cases were diagnosed below the age of 55 years. Geng et al https://doi.org/10.1371/journal.pone.0231341.g002 PLOS ONE [46] have also shown a higher frequency of PTC with BRAF V600E mutation in pediatric age group of less than 10 years of age.…”

Section: Plos Onementioning

confidence: 86%

“…Papillary thyroid carcinoma is the most prevalent type of thyroid cancer worldwide [16]. A lot of works have been done to identify fundamental mechanisms involved in the development of PTC [13,14,[16][17][18][19][20][21]. Many studies have shown a constant rise in the incidence of PTC in different countries all over the world over the last decades [17].…”

Section: Discussionmentioning

confidence: 99%

BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates

et al. 2020

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Background Papillary thyroid carcinoma (PTC) is the most common malignant thyroid neoplasm comprising 80-90% of all thyroid malignancies. Molecular changes in thyroid follicular cells are likely associated with the development of PTC. Mutations in serine/threonine-protein kinase (BRAF) and Rat sarcoma viral oncogene homolog (RAS) are commonly seen in PTC. Methods In total, 90 cases of PTC are randomly selected from archive paraffin blocks and 10μm sections were cut and processed for DNA extraction. BRAF V600E mutation and 8 types of KRAS mutations were investigated using Real Time PCR. Results BRAF V600E mutation was identified in 46% of PTC while KRAS mutations were seen in 11% of PTC. There was significant correlation between BRAF V600E mutation and PTC larger than 5cm in diameter, positive surgical margin and lymph node metastasis. BRAF V600E mutation was significantly higher in patients with less than 55-year of age than those more than 55-year of age. BRAF V600E mutation was significantly higher in patients with family history of thyroid cancer than those without. There was no significant difference in BRAF V600E mutation between males and females, PTC classic and follicular variants, unifocal and multifocal PTC. There was a significant higher percentage of BRAF V600E mutation in classic PTC than papillary microcarcinoma variant. There was no significant age, gender, histologic type, tumor size, lymph node metastasis, tumor focality, and surgical margin status differences between KRAS mutated and non-mutated PTC.

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“…The reported rate of thyroid carcinoma among all malignancies is approximately 1%. In Saudi Arabia, thyroid cancer was the second most common malignancy after breast cancer, while it was reported as the third most common in the United Arab Emirates and fourth most common cancer in Filipino women 9 .…”

Section: Introductionmentioning

confidence: 99%

Pattern of Primary Thyroid Malignancy in a Tertiary Care Hospital

Islam

Talukder

et al. 2020

J Dhaka Med Coll

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Background: Among the endocrine malignancies thyroid cancer is the most common. It constitutes a heterogeneous group of malignancies ranking it as the fifth most common cancer worldwide. On health as well as health system it has severe implication. Thyroid cancer incidence is rising most rapidly worldwide. Different thyroid malignancy requires different management strategy. Proper addressing and prompt management of different thyroid malignancies can lessen the suffering. Objective: The study aimed to evaluate the pattern of primary thyroid malignancy in a tertiary care hospital. Methods: The study was a hospital based descriptive cross sectional study and was conducted in Dhaka Medical College Hospital, Dhaka for one-year period following approval of this protocol. Patients suffering from primary thyroid carcinoma admitted in or attending the outpatient department (OPD) in the department of Otolaryngology and Head-Neck Surgery was approached for inclusion in the study. Written informed consent was taken from the subject and ethical issues were ensured. A total of 50 individual suffering from primary thyroid carcinoma calculated by sample size formula was selected by inclusion and exclusion criteria and data was collected by interview using a semi-structured questionnaire and by personal document analysis. Collected data was analyzed by the SPSS 20 for windows. This study reflects the pattern of primary thyroid malignancy in a tertiary care hospital in Bangladesh. Results: Mean age of the participants was 32.7 years with SD ± 13.8 years, Minimum age was 17 years and maximum age was 70 years. Majority of the patients (46%) were in the age group of 31- 40 years. Among the participants, 70% were female and 30% were male. The majority of the patients belong to Dhaka and Rangpur divisions (26% & 22% respectively) of which maximum patients were from rural area (70%). By occupation, maximum (22%) of the study subjects were businessman, maximum study subjects were below SSC (24%) and maximum patients (42%) had relatively low income per month. Half of the participants had habit of tobacco. All patients (100%) had presented with palpable thyroid swelling. Among the total participants 54% had lymphadenopathy, 10% had dysphagia, 4% had hoarseness of voice and 4% had lumpiness in throat. Only 2% of patients had the symptom of dyspnoea. No palpable lymph nodes were found in 46% followed by Single node lymphadenopathy 26%, multiple nodules in one side in 18%, bilateral lymphadenopathy 8% and 20% participants had Central compartment lymphadenopathy. USG findings of thyroid revealed Single solid nodule in 22.0%, Single cystic nodule in 16.0%, multiple mixed (solid + cystic) nodules in 62.0% cases. FNAC findings revealed Anaplastic carcinoma in 2.0%, Follicular neoplasm in 16.0% and Follicular variant of papillary carcinoma in 8.0%. Papillary carcinoma found in maximum 70.0% cases. No lymphoma found whereas medullary carcinoma found in 4.0% cases. Histopathological findings confirmed Anaplastic carcinoma in 4.0%, Follicular carcinoma in 16.0%, Follicular variant of papillary carcinoma in 8.0% and Papillary carcinoma 68.0% cases. By histopathological examination no lymphoma found whereas medullary carcinoma found in 4.0% cases. Only 24% participants had hypertension and 76% had DM as co-morbid diseases. Distant metastasis of carcinoma was not present in any of the participants. Conclusion: In this study, middle age group and female sex prevalent thyroid cancer. Geographical distribution also has an important role. Business, low educational level, low socioeconomic status and tobacco smoking are found the most important risk factors. Histopathologically papillary carcinoma was predominant followed by follicular carcinoma, follicular variant of papillary carcinoma, anaplastic carcinoma and medullary carcinoma. No lymphoma found. J Dhaka Medical College, Vol. 27, No.2, October, 2018, Page 161-174

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Thyroid carcinoma in the United Arab Emirates: perspectives and experience of a tertiary care hospital

Cited by 32 publications

References 29 publications

Thyroid Surgeries in a Single Centre, 2010 - 2014

Thyroid Surgeries in a Single Centre, 2010 - 2014

BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates

Pattern of Primary Thyroid Malignancy in a Tertiary Care Hospital

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