Thyroid carcinoma in patients with secondary hyperparathyroidism

Abstract

There have been few reports of coexistence of secondary hyperparathyroidism (2 degrees HPT) and thyroid carcinoma. Eleven consecutive patients with 2 degrees HPT who underwent parathyroidectomy were analyzed. They consisted of six males and five females, whose age ranged from 34 to 55 years. None of the patients had a history of irradiation of the head or neck. Associated thyroid nodules were also present in seven patients (64%): four patients with benign nodules, and three patients with papillary carcinomas, and one with papillary carcinoma and two follicular adenomas. This incidence of thyroid carcinoma in the patient group with 2 degrees HPT (36%) was significantly higher than that of the autopsy group in the same geographical area (11%). The level of carboxyl-terminal parathyroid hormone in the patients with thyroid carcinoma was higher than that in the patients without thyroid carcinoma (P less than 0.05). The importance of searching for possible thyroid cancer in patients with 2 degrees HPT should be emphasized.

Usefulness of the combination of ultrasonography and 99mTc‐sestamibi scintigraphy in the preoperative evaluation of uremic secondary hyperparathyroidism

“…The frequency of association of thyroid nodular disease or carcinoma with SHPT ranges between 3% and 37%. [50][51][52] Such association is considered casual and similar to that of the general population. 15,53,54 However, it is well known that the detection of abnormal PTGs by both ultrasonography and scintigraphy may be impaired in the presence of nodular 28,55,56 or multinodular thyroid disease.…”

Endocrine Complications of Chronic Kidney Disease

“…They also have a higher incidence of goiter, thyroid nodules and thyroid carcinoma. 88,89 Serum TSH concentrations are usually normal or elevated in CKD, but its response to thyrotropin-releasing hormone (TRH) is often diminished. Also, both TSH circardian rhythm and TSH glycosylation are changed in CKD.…”

Clinicopathological Characteristics of Thyroid Cancer in Patients on Dialysis for End-Stage Renal Disease

“…Thyroid cancer was found in 36% of 11 ESRD patients from Japan with secondary HPT at surgery, compared with 11% in an autopsy control group (17). In contrast, only 2.4% of 123 ESRD patients undergoing surgery for severe secondary HPT in the United Kingdom had thyroid cancer (18).…”