Thyroid Carcinoma in Children and Adolescents—Systematic Review of the Literature

Vaisman, Fernanda; Corbo, Rossana; Vaisman, Mário

doi:10.4061/2011/845362

Cited by 75 publications

(87 citation statements)

References 69 publications

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“…1 Differentiated thyroid carcinomas (DTC) represent the most common endocrine tumor in childhood affecting 0.1-2.2 children per million persons. 1 Of all the DTCs, papillary thyroid carcinoma (PTC) constitute 70-80% of cases followed by follicular carcinoma. 1 The clinical presentation and outcome of pediatric DTCs is different from that of adults.…”

Section: Introductionmentioning

confidence: 99%

“…1 Of all the DTCs, papillary thyroid carcinoma (PTC) constitute 70-80% of cases followed by follicular carcinoma. 1 The clinical presentation and outcome of pediatric DTCs is different from that of adults. In children, DTCs tend to be more advanced at the time of presentation as compared to adults.…”

Section: Introductionmentioning

confidence: 99%

“…Regional lymph node metastasis is detected in 90% of children at the time of initial diagnosis as compared to only 35% in adults. 1 Pediatric DTCs present with multifocal lesions, extrathyroidal invasion and distant metastasis, indicating that childhood thyroid carcinomas have an aggressive clinical course. 1 However, the overall survival rates exceed 95% in children as compared to an average of 80-90% in adults.…”

Section: Introductionmentioning

confidence: 99%

“…1 Pediatric DTCs present with multifocal lesions, extrathyroidal invasion and distant metastasis, indicating that childhood thyroid carcinomas have an aggressive clinical course. 1 However, the overall survival rates exceed 95% in children as compared to an average of 80-90% in adults. 2 Treatment modalities include surgery and radioiodine ( 131 I) ablation (RIA) or treatment aimed at eliminating normal-thyroid remnants or any neoplastic focus.…”

Section: Introductionmentioning

confidence: 99%

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Pediatric papillary thyroid carcinoma successfully managed with a multimodal approach

et al. 2017

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Malignant tumours of the thyroid gland are rare in children. The tumours tend to be advanced at the time of presentation, but the overall survival is still better as compared to adults. The use of radioiodine ablation or treatment for the post-thyroidectomy gland remnants or recurrences improves patient survival. The reports of a multimodal approach that involves surgery as the primary treatment along with radioiodine ablation (RIA) are rare in the pediatric age group. We describe here a child with metastatic papillary thyroid carcinoma treated with a multimodal approach.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pediatric papillary thyroid carcinoma successfully managed with a multimodal approach

et al. 2017

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“…Thyroid nodules seem to be rare disorders in children and adolescents, although thyroid cancers are extremely rare in the pattern of thyroid pathologies, especially at ages younger than 5 years [6,9]. Thyroid cancers occur in 0.5-3.0% of all pediatric malignancies [1,14]. One of the most difficulties in nodular thyroid disease is the absence of any clinical signs, such as pain of the anterior surface of the neck, high temperature, skin rash or discomfort in that region.…”

Section: Introductionmentioning

confidence: 99%

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2016

RJLBPCS

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ABSTRACT:The incidence of follicular thyroid cancer (FTC) varies in different countries and is more common in women increasing with age in general population. There is lack of similar data concerning paediatric population. FTA is difficult to diagnose by fine-needle aspiration, thus any follicular thyroid tumor need to be excised for further identification of its malignant or benign character. Overwhelming majority of FTC cases are asymptomatic and euthyroid, which exacerbate the early diagnosis and clinical manifestation of thyroid nodules. Therefore they are detected by routine physical examination without clinical signs of thyroid dysfunction. USG examination is useful for monitoring nodule size and for the fine-needle aspiration (FNA) of nodules and cysts, but not for identifying of cancers. We present a case report of a 3.5 years old child with swelling of the left lateral-anterior aspect of the neck without clinical complaints that was first noticed about 4 months before. There was no family history of any cancers, nor a history of exposure to radiation. TSH and free T4 levels, as well as autoantibodies against thyroid gland were measured and found to be in normal ranges. A nodule of 4.2cm in diameter by USG examination, and follicular neoplasm by ultrasound-guided FNA has been revealed. Surgical excision -lobectomy was performed with further histology of the tumor. The final pathohistological diagnosis was follicular carcinoma, which is very rare state in children. Postoperatively the boy was not administrated levothyroxine suppressive therapy to escape unnecessary side effects from excess of hormone intake. He is under intensive monitoring up to now. After 5 years of monitoring no other nodule development was dated, euthyroidism clearly remain, lymphadenopathy of neck is absent.

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Thyroid Disorders

2019

Practical Endocrinology and Diabetes in Children

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Thyroid Carcinoma in Children and Adolescents—Systematic Review of the Literature

Cited by 75 publications

References 69 publications

Pediatric papillary thyroid carcinoma successfully managed with a multimodal approach

Pediatric papillary thyroid carcinoma successfully managed with a multimodal approach

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Thyroid Disorders

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