Thyroid carcinoma: clinical, pathologic correlations

Medullary thyroid carcinoma experienced at Kanazawa University Hospital

“…Although the number of cases examined in this series is small, it was found that MTC carries a worse prognosis than that of papillary and follicular thyroid carcinoma, the latter of which was defined in our previous prognostic study at our hospital [39]. Not only histologic, immunohistochemical, or DNA analysis, but also more recently developed oncogene or chromosome analysis should be included in the studies to clarify the pathobiology of MTC in the future [40].…”

Therapeutic strategies and long-term results in differentiated thyroid cancer

“…Although prognostic information has been obtained in this manner in several series, it does not seem to have any prognostic advantage when compared with the AGES or AMES systems. However, recent developments in biochemistry and molecular genetics, involving oncogene and anti-oncogene activation and chromosomal abnormalities, will provide valuable data in clarifying the biologic behavior of DTC [2].…”

“…However, there is disagreement about the use of radioiodine therapy in patients who do not initially have distant metastases. Some investigators [5,67,87] have treated large numbers of patients with near-total thyroidectomy and radioiodine, (26) 35 (9) ] NS 8 (2) ] NS Modified neck dissection (7) 29 (2) 14 ( (24) 50 (12) ] P ‫ס‬ 0.0246 25 (6) ] NS Modified neck dissection (20) 15 (3) 10 (2) Hamming et al [42] Node plucking (32) 6.3 (2) ]…”

“…However, DTC, particularly papillary thyroid carcinoma, happens to be a multicentric tumor and tends to spread to the regional lymph nodes in the early stage of the disease [7]; some patients do die from DTC. Several investigators have analyzed various prognostic factors and have found that age, sex, tumor size, histologic type and grade of the tumor, and distant metastases are significant prognostic factors [1][2][3]8]. Other investigators have introduced scoring systems based on a patient's age, tumor size, tumor grade, and the presence of metastases [9,10].…”

“…They represent more than 85-90% of all thyroid malignancies [1][2][3][4] and together are known as differentiated thyroid carcinoma (DTC). Numerous clinicopathologic studies have documented that DTC has an excellent prognosis [1,5,6].…”