Thyroid cancer mortality is higher in Filipinos in the United States: An analysis using national mortality records from 2003 through 2012

Nguyen, Michelle; Hu, Junjie; Hastings, Katherine; Daza, Eric J.; Cullen, Mark R.; Orloff, Lisa A.; Palaniappan, Latha

doi:10.1002/cncr.30958

Cited by 19 publications

(21 citation statements)

References 27 publications

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“…Although some previous reports imply that the prognosis of TC mortality in men is poorly understood, contrary findings have also been reported [6,35,36]. Our findings differ from the widely held belief that men show poorer outcomes than women when diagnosed with TC [6,35]. Nevertheless, the underlying reason for mortality being higher in women than in men as observed in our study is unclear.…”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, the possible existence of a genetic predisposition in the host or a tumor that influences TC mortality, as described in other ethnicities [35] should not be ruled out. Along this line, the relative isolation of the afflicted areas (which were practically inaccessible until a few years ago) may be characterized by a tendency toward high consanguinity.…”

Section: Discussionmentioning

confidence: 99%

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Trends of Thyroid Cancer Mortality Rates in Ecuador

Gavilánez¹,

Franco²,

Bajaña³

et al. 2018

JED

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Objective: To analyze thyroid cancer (TC) mortality rates from 1990 to 2016 in Ecuadorian men and women and compare their trends with Latin American and international trends. Design: A population-based temporal-trend study using the database of the Ecuadorian National Death Registry. Methods: Crude and age-adjusted mortality rates were calculated, and age-related mortality rates were standardized with the world population (WHO). Trends in age-standardized mortality rates were estimated by jointpoint regression analysis. The trends were expressed as annual percentage change (APC) and average annual percentage change (AAPC). Results: In total, TC caused 2,107 deaths (1,475 women and 632 men) in the selected period. The mortality in men showed a statistically non-significant decrease. The estimated APC was −0.4% (P = 0.70), and the AAPC was −0.4% (P = 0.70) without any identified jointpoint. In women, the mortality decreased significantly between 1990 and 1998, with the estimated APC being −6.6% (P < 0.05). However, it increased significantly from 1998 to 2016, with the estimated APC of 5.4% (P < 0.05), and a jointpoint was identified; the AAPC was 1.4 (P = 0.30). Conclusions: While TC mortality in Ecuadorian men showed a decrease, that in Ecuadorian women showed an initial decrease and a final increase. Our findings can be contrasted with the global data, which show decreases in TC mortality in both sexes.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trends of Thyroid Cancer Mortality Rates in Ecuador

Gavilánez¹,

Franco²,

Bajaña³

et al. 2018

JED

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“…However, unexpected adverse pathologic features identified only on the final pathology report can often prompt return to the operating room for completion surgery. Asian patients especially are at an increased risk for differentiated thyroid cancers, and the literature suggests they can have worse disease‐specific outcomes . To our knowledge, this is the first study in the literature to evaluate for ethnic variations in adverse pathologic features in Chinese versus non‐Asian patients.…”

Section: Discussionmentioning

confidence: 96%

Unexpected high‐risk pathologic features following thyroidectomy in the chinese immigrant population

et al. 2019

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Objective To compare rates of unexpected high‐risk pathologic features between Chinese and non‐Asian patients who underwent thyroidectomy for papillary thyroid cancer. Methods This was a retrospective cohort study at a tertiary academic urban medical center. Patients who underwent thyroidectomy for papillary carcinoma from 2015 to 2017 were included. Patient demographics, tumor characteristics, and tumor histopathology were analyzed. Primary outcome was the presence of adverse histopathologic features such as lymphovascular invasion (LVI) or microscopic/minimal extrathyroidal extension (mETE). Differences between the groups were analyzed using multivariate logistical regression analysis and propensity score‐weighted analysis. Results One hundred seventy‐nine patients were included: 58 Chinese‐born and 121 non‐Asian. The median age of the cohort was 47 years old (36–58). Twenty‐nine percent of patients were male, and 71% were female. There was no statistically significant difference between the two cohorts in rates of LVI, multifocality, extent of surgery, or presence of thyroiditis. Patients with mETE were more likely to have larger tumors (P = 0.00247). Both the multivariate and propensity‐weighted models demonstrated that Chinese ancestry was independently associated with an increased rate of unexpected mETE (adjusted prevalence ratio, 2.52; 95% confidence interval, 1.82–3.48). Conclusion mETE is significantly higher in the immigrant Chinese compared to the non‐Asian population. Given the high prevalence of unexpected mETE in the Chinese population, the added risk of this finding should be brought into the discussion during initial surgical planning. Level of Evidence 3 Laryngoscope, 130:1844–1849, 2020

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“…There are con icting reports on the effect of sex on mortality. Ito and Miyauchi [26] and Lin et al [27] found that a larger proportion of male than female patients died of thyroid cancer, whereas Nguyen et al [28] found the opposite result. Bray et al [25] reported that the mortality rates were similar in the sexes, based on global cancer statistics published in 2018.…”

Section: Discussionmentioning

confidence: 97%

Prognostic factors in patients with thyroid carcinoma: a competing-risks analysis

Wang

Yang

et al. 2020

Preprint

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Background: Cox proportional-hazards models are widely used to describe survival trends and identify prognostic factors for thyroid carcinoma, but the prognostic model is not accurate enough. This study therefore used a competing-risks model to identify the significant prognostic factors for different types of thyroid carcinoma.Methods: We identified 38,444 eligible patients in the SEER (Surveillance, Epidemiology, and End Result) database. The potential prognostic factors for thyroid carcinoma were analyzed by Cox regression analysis, cause-specific hazard function (CS) analysis, and subdistribution hazard function (SD).Results: Cox regression analysis, CS analysis and SD analysis found identifying age, being unmarried, no regional lymph nodes examined, AJCC-6 II, III, IV vs I , having follicular, medullary, anaplastic vs Papillary carcinomas, no surgery, no radioiodine, liver metastasis, and lung metastasis as the significant risk factors for thyroid carcinoma, while being female was protective factor. However, the results from the three multivariate models for being black, tumor size >1 cm, and brain metastasis were inconsistent.Conclusion: In addition to finding that age, pathological type, tumor size, AJCC-6 stage, surgery status, radioiodine status, metastasis as common factors affected the prognosis, we also found that women, being unmarried and had their regional lymph nodes examined can improve the prognosis of thyroid cancer. The discovery of these factors will provide evidences for the prevention and treatment of thyroid cancer.

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Thyroid cancer mortality is higher in Filipinos in the United States: An analysis using national mortality records from 2003 through 2012

Cited by 19 publications

References 27 publications

Trends of Thyroid Cancer Mortality Rates in Ecuador

Trends of Thyroid Cancer Mortality Rates in Ecuador

Unexpected high‐risk pathologic features following thyroidectomy in the chinese immigrant population

Prognostic factors in patients with thyroid carcinoma: a competing-risks analysis

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