Thyroid cancer incidence around the Belgian nuclear sites: Surrogate exposure modelling

Bollaerts, Kaatje; Sonck, M.; Simons, Koen; Fierens, Sébastien; Poffijn, A.; Bladel, Lodewijk Van; Geraets, David; Gosselin, Pol; Oyen, Herman Van; Francart, Julie; Nieuwenhuyse, An Van

doi:10.1016/j.canep.2014.10.011

Cited by 7 publications

(16 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this ecological study, performed at the level of the communes (municipalities), showed no higher incidence of thyroid cancer around the two Belgian nuclear power plants. For the two nuclear sites with research and industrial activities, a slightly higher incidence of thyroid cancer was observed compared to the regional average …”

Section: Introductionmentioning

confidence: 82%

“…For the two nuclear sites with research and industrial activities, a slightly higher incidence of thyroid cancer was observed compared to the regional average. [15][16][17][18] The present study is the follow-up thereof and follows the recommendation to make data available at smaller geographical level. The present study was performed at the level of the statistical sectors, a subdivision of commune.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thyroid cancer incidence near nuclear sites in Belgium: An ecological study at small geographical level

Demoury

Schutter²,

Faes

et al. 2019

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

In Belgium, variations in thyroid cancer incidence were observed around the major nuclear sites. The present ecological study investigates whether there is an excess incidence of thyroid cancer among people living in the vicinity of the four nuclear sites at the smallest Belgian geographical level. Rate ratios were obtained from a Bayesian hierarchical model for areas of varying sizes around the nuclear sites. Focused hypothesis tests and generalized additive models were performed to test the hypothesis of a gradient in thyroid cancer incidence with increasing levels of surrogate exposures. No evidence was found for more incident cases of thyroid cancer near the two nuclear power plants. Regarding the two industrial and research nuclear sites, no evidence for a higher incidence in the vicinity of Mol‐Dessel was observed, whereas a slightly nonsignificant higher incidence was found in the close vicinity of Fleurus. In addition, significant gradients for thyroid cancer incidence were observed with the different types of surrogate exposure considered in the 20 km area around the site of Fleurus (decreasing distance, increasing wind direction frequency and increasing exposure to estimated hypothetical radioactive discharges of iodine‐131). In the investigation at the smallest Belgian geographical level, variations in thyroid cancer incidence were found around the Belgian nuclear sites. Significant exposure–response relationships were also observed for the site of Fleurus. Further investigations into these findings could be useful to allow inferring causal relationships on the origin of variations in incidence and to provide information at the individual level.

show abstract

Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Thyroid cancer incidence near nuclear sites in Belgium: An ecological study at small geographical level

Demoury

Schutter²,

Faes

et al. 2019

Intl Journal of Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Even the elevated rate of well-differentiated thyroid cancer around the nuclear plants is debated. 123,124 The influence of radiation has also been recognized when the exposure occurs in children. Case-control studies have shown a 2-fold increase in incidence when children had a history of exposure to dental X-rays.…”

Section: Radiationmentioning

confidence: 99%

“…Nonetheless, the evidence of effects in areas far away from the accident, under the path of the “radioactive cloud” is weak. Even the elevated rate of well‐differentiated thyroid cancer around the nuclear plants is debated …”

Section: Introductionmentioning

confidence: 99%

Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis

et al. 2017

View full text Add to dashboard Cite

There is an increasing incidence of well-differentiated thyroid cancer worldwide. Much of the increase is secondary to increased detection of small, low-risk tumors, with questionable clinical significance. This review addresses the factors that contribute to the increasing incidence and considers environmental, and patient-based and clinician-led influences. Articles addressing the causes of the increased incidence were critically reviewed. A complex interplay of environmental, medical, and social pressures has resulted in increased awareness of the thyroid disease risk, increased screening of thyroid cancers, and increased diagnosis of thyroid cancers. Although there is evidence to suggest that the true disease incidence may be changing slightly, most of the increase is related to factors that promote early diagnosis of low-risk lesions, which is resulting in a significant phenomenon of overdiagnosis. An improved understanding of these pressures at a global level will enable healthcare policymakers to react appropriately to this challenge in the future.

show abstract

“…However, they allow to build complex high non-linear models [21][22][23][24] which it is very difficult to achieve with RSM or too complex with NN. They are then found to be a valuable tool to support a wide scope of activities in modern engineering design such as chemical and materials engineering [25,26], and other fields such as agriculture and ecology [27,28], medicine [29][30][31] and economy [32].…”

Section: Introductionmentioning

confidence: 99%

Performance Comparison of Kriging and SVR Surrogate Models Applied to the Objective Function Prediction Within Aerodynamic Shape Optimization

Viúdez‐Moreiras¹,

Andrés-Pérez²,

González-Juárez³

et al. 2016

Proceedings of the VII European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2016)

View full text Add to dashboard Cite

show abstract

Thyroid cancer incidence around the Belgian nuclear sites: Surrogate exposure modelling

Abstract: The re-analyses refute an association with the nuclear facilities for the site of Mol-Dessel. For the site of Fleurus, one of Europe's major production sites of radio-iodines, the results were less conclusive and further research suggests itself.

Cited by 7 publications

References 28 publications

Thyroid cancer incidence near nuclear sites in Belgium: An ecological study at small geographical level

Thyroid cancer incidence near nuclear sites in Belgium: An ecological study at small geographical level

Growing incidence of thyroid carcinoma in recent years: Factors underlying overdiagnosis

Performance Comparison of Kriging and SVR Surrogate Models Applied to the Objective Function Prediction Within Aerodynamic Shape Optimization

Contact Info

Product

Resources

About