Thyroid Cancer Incidence 25 Years After Chernobyl, in a Romanian Cancer Center: Is it a Public Health Problem?

Piciu, Doina

doi:10.2174/1874471006666140109114218

Cited by 17 publications

(15 citation statements)

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“…For example, children less than 10 years of age present more aggressive forms of the disease [19]. Therefore, we decided to review the literature on pediatric thyroid cancer, focusing on the European population, with the major interest being the impact of the Chernobyl accident [20,21].…”

Section: Introductionmentioning

confidence: 99%

Pediatric Thyroid Cancer in Europe: An Overdiagnosed Condition? A Literature Review

et al. 2020

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Thyroid neoplastic pathology is the most common form of cancer associated with radiation exposure. The most common histopathological type of thyroid carcinoma is the differentiated thyroid cancer (these include papillary and follicular type), which represents over 90% of all cases, especially affecting girls rather than boys. Although patients are diagnosed in advanced stages as compared to adults, the prognosis of the disease is very good, with a 30-year survival rate of over 95% but post-therapeutic morbidity remains quite high. The treatment is based in particular on the therapeutic guidelines for adults, but as children have some histopathological and genetic characteristics of thyroid cancer, as well as different initial clinical presentations, we decided to review the literature on this pathology among the pediatric population, focusing on cases in Europe. The major interest is the impact of the Chernobyl accident.

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Section: Introductionmentioning

confidence: 99%

Pediatric Thyroid Cancer in Europe: An Overdiagnosed Condition? A Literature Review

et al. 2020

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“…The most frequent histopathological type of thyroid cancer (90% of all cases) is differentiated thyroid cancer (including papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) types), with a higher incidence in girls [ 5 , 6 , 7 ]. Although in children, the diagnosis is finally established in more advanced stages compared with adults, the disease prognostic is very good, with the overall survival at 30 years being over 95% [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania

Stefan

Piciu

Căinap

et al. 2020

JCM

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Pediatric thyroid carcinoma is a current area of interest, because there are few studies in this field; the current classification and treatment guidelines are extrapolated from adults, sometimes leading to overly aggressive treatments or incomplete treatment of the disease. The purpose of this retrospective study is to analyze the presentation, diagnosis, treatment, complications, and outcome of children diagnosed with thyroid cancer in the last two decades (2000–2018) at the Oncological Institute “Prof. Dr. Ion Chiricuță” Cluj-Napoca (IOCN) Romania, a tertiary center in a region with environmental influences from both the nuclear fallout of the Chernobyl accident and from iodine deficiency. The results were compared with those obtained in a previous study carried out in the same institution between 1991–2010, and with those obtained in a similar study carried out in Netherlands between 1970–2013, a cohort of children not exposed to the post-Chernobyl fallout. We statistically analyzed 62 patients. Papillary form was present in the majority of cases, and we highlighted the occurrence of thyroid microcarcinoma in children. A total of 85.4% of patients received radioiodine, the total activity being significantly lower compared with the data from literature. In our study, the prognosis of the disease was excellent, with 100% overall survival.

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“…Analysis of demographic and onco-epidemiological consequences of the Chornobyl catastrophe indicates that the minimization of the aftermath and increase in the efficiency of medical treatment for the people affected by the radiation are not only relevant, but are should be a priority in the next few years. Particularly, the necessity of continuation of the studies on assessment of long-term consequences of the Chronobyl explosion is mentioned in the studies by Baverstock & Williams (2006), Saenko et al (2011), Piciu (2013), Aitsi-Selmi & Murray (2016). The importance of continuing monitoring of the characteristics of long-term picture of 131 І risk in the groups affected by the iodine irradiation in childhood and teens is emphasized in the study by Tronko et al (2017), Domina (2015) and Prykashсhykova et al (2018).…”

Section: Discussionmentioning

confidence: 99%

Demographic and onco-epidemiological situation in radioactive contaminated territory of Zhytomyr Oblast

Herasymchuk

Martenyuk

Valerko

et al. 2019

Regul. Mech. Biosyst.

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We performed an assessment of demographic parameters of occurrence of malignant tumours and mortality of the population which lives in the radioactive contaminated territory of Zhytomyr Oblast (Yemilchynskyi, Luhynskyi, Narodytskyi, Korostenskyi, Olevskyi, and Ovrutskyi districts) over a 32-year period (1985–2017). The source material for the study of the demographic situation and malignant tumours in the population of the radioactive contaminated administrative districts of Zhytomyr Oblast during 1985–2017 was the statistical data of the Management of Healthcare of Zhytomyr Oblast State Administration, Central Department of Statistics in Zhytomyr Oblasts, reports on occurrences of malignant tumours of the state institution Center of Medical Statistics of the Ministry of Healthcare of Ukraine, data of the Radiological Control Service in Zhytomyr Oblast. It was determined that over 1985–2017 in the radioactive contaminated territory of Zhytomyr Oblast, a natural decline of population was observed, maximum values of which occurred in 2005 (except Narodnytsky district – 2000). The highest levels of occurrence of tumours and mortality caused by them among the adult population were observed 14 years after the Chornobyl nuclear power plant disaster. The peak of the occurrence of malignant tumours among children in the radioactive contaminated territory of Zhytomyr Oblast was observed 9 years after the explosion. A relationship was determined between doses of irradiation of the population and the risk of occurrence of malignant tumours in the radioactive contaminated regions of Zhytomyr Oblast. Taking into account that the method of calculation of passport dose (average annual effective dose of irradiation) was developed 23 years ago, nowadays it can lead to errors. This is related to change in amounts of consumption of different products by the population, which needs to be considered when determining radiological risks. The obtained data indicate that analysis of demographic and onco-epidemiological consequences of the Chornobyl catastrophe remains a relevant issue nowadays and will remain so in the near future.

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Thyroid Cancer Incidence 25 Years After Chernobyl, in a Romanian Cancer Center: Is it a Public Health Problem?

Cited by 17 publications

References 0 publications

Pediatric Thyroid Cancer in Europe: An Overdiagnosed Condition? A Literature Review

Pediatric Thyroid Cancer in Europe: An Overdiagnosed Condition? A Literature Review

Differentiated Thyroid Cancer in Children in the Last 20 Years: A Regional Study in Romania

Demographic and onco-epidemiological situation in radioactive contaminated territory of Zhytomyr Oblast

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