Thyroid cancer in children: a 20-year study at a Romanian oncology institute

Piciu, Doina; Piciu, Doina; Irimie, Alexandru

doi:10.1507/endocrj.ej11-0397

Cited by 17 publications

(23 citation statements)

References 29 publications

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“…This increase in incidence is not determined by a more intensive initial screening but the emergence of more new cases, most likely determined by external factors (nuclear radiation) [22,24]. The new cases were found to be more aggressive, with significant local invasion and distant metastases [5,22,38]. The first studies did not conclude a causal relationship between irradiation and the onset of thyroid cancer.…”

Section: Epidemiologymentioning

confidence: 99%

“…In the countries directly affected by the Chernobyl accident, the trend is increasing. The number of newly diagnosed cases in the period immediately following 1986 increased exponentially [4,5,13,31,33,37]. Those who were children at the time of the accident became young adults in 2002, determining the increase of incidence in this population, while there was a decrease of the incidence of thyroid cancer in young children.…”

Section: Epidemiologymentioning

confidence: 99%

“…Pediatric thyroid cancer is one of the rarest endocrine tumors, yet the incidence rate increases by 1.1% per year. This increase is real, mostly because of the different environmental factors (ionizing radiation, volcanic activity, nitrate concentration in drinking water), unlike in the case of adults, where ultrasound screening plays an important role [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Thyroid Cancer in Europe: An Overdiagnosed Condition? A Literature Review

et al. 2020

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Thyroid neoplastic pathology is the most common form of cancer associated with radiation exposure. The most common histopathological type of thyroid carcinoma is the differentiated thyroid cancer (these include papillary and follicular type), which represents over 90% of all cases, especially affecting girls rather than boys. Although patients are diagnosed in advanced stages as compared to adults, the prognosis of the disease is very good, with a 30-year survival rate of over 95% but post-therapeutic morbidity remains quite high. The treatment is based in particular on the therapeutic guidelines for adults, but as children have some histopathological and genetic characteristics of thyroid cancer, as well as different initial clinical presentations, we decided to review the literature on this pathology among the pediatric population, focusing on cases in Europe. The major interest is the impact of the Chernobyl accident.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pediatric Thyroid Cancer in Europe: An Overdiagnosed Condition? A Literature Review

et al. 2020

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“…In some European regions contaminated by radioactive fallout after the ChNPP accident (but not in all regions with detected increase in radiation), an increase in thyroid cancer incidence and Down syndrome was reported (Kurttio et al 2013;Auvinen et al 1994;Piciu et al 2012;Sperling et al 1991).…”

Section: Cancer Incidence and Down Syndrome In Children After Chnpp Nmentioning

confidence: 99%

Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident

et al. 2016

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As children are more susceptible to ionizing radiation than adults, each nuclear accident demands special attention and care of this vulnerable population. The Chernobyl nuclear disaster occurred in a region populated with a large number of children, but despite all efforts and expertise of nuclear specialists, it was not possible to avoid casualties. As vast regions of Ukraine, Belarus and Russia were exposed to doses of ionizing radiation, which are known to be related with different diseases, shortly after the accident medical surveillance was launched, which also included analysis of genome damage. Child population affected by internal and external radiation consisted of subjects exposed prenatally, postnatally (both evacuated and non-evacuated), born by irradiated fathers who worked as liquidators, and parents exposed environmentally. In all groups of children during the last 30 years who were exposed to doses which were significantly higher than that recommended for general population of 1 mSv per year, increased genome damage was detected. Increased genome damage includes statistically higher frequency of dicentric and ring chromosomes, chromated and chromosome breaks, acentric fragments, translocations, and micronuclei. The presence of rogue cells confirmed internal contamination. Genome instability and radiosensitivity in children was detected both in evacuated and continuously exposed children. Today the population exposed to ionizing radiation in 1986 is in reproductive period of life and follow-up of this population and their offspring is of great importance. This review aims to give insight in results of studies, which reported genome damage in children in journals without language restrictions.

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“…Although thyroid cancers exhibit a rapid course in children, they do not affect life span (36). Papillary carcinoma is the most commonly seen thyroid cancer (85%), followed by the follicular type (10%).…”

Section: Ultrasound Is the Imaging Technique Of Choice In Thyroid Patmentioning

confidence: 99%

Thyroid Cancer in Children of Eastern Anatolia

Kaya¹,

Çayır²,

Orbak³

et al. 2014

WIMJ Open

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Introduction: The incidence of thyroid cancer has been increasing in recent years. In this study, the clinical and laboratory findings of 14 patients with thyroid cancer were analysed retrospectively. They were admitted to our clinic with complaints of swelling of the neck. Methods: This study was performed in the Paediatric Endocrinology Polyclinics of Ataturk University Faculty of Medicine between 2008 and 2013. Patients with a diagnosis of thyroid cancer/hyperplasia were included. Patients' age and gender, a family history of goitre and thyroid cancer, and exposure to radiation were elicited. Free thyroxine (T4), thyroid stimulating hormone, thyroglobulin and urinary iodine levels were measured. Ultrasonographic characteristics of nodules were determined. Fineneedle aspiration biopsy was performed if nodules were ≥ 10 mm in diameter. Results: The number of males and females was equal. There was no history of neck radiation. Grade 4 and grade 3 goitres were detected in four (28.5%) and 10 (71.4%) of 14 patients, respectively. The use of rock and iodized salt was determined in nine (64.2%) and three (21.4%) patients, respectively, while two (14.2%) patients have been using both forms of salt. According to biopsy findings, benign thyroid tissue was present in three (21.4%) patients, while papillary cancer, follicular carcinoma and hyperplasia were determined in six (42.8%), three (21.4%) and five (35.7%) patients, respectively. Conclusion: Even if the biopsy findings are normal, surgery must be done in the presence of a history of bleeding in a nodule, fixation of a nodule and cervical lymphadenopathy. Iodine deficiency is an important risk factor for thyroid cancer. People should be informed about iodine deficiency and iodized products should be provided to those who live in areas with endemic iodine deficiency.

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Thyroid cancer in children: a 20-year study at a Romanian oncology institute

Cited by 17 publications

References 29 publications

Pediatric Thyroid Cancer in Europe: An Overdiagnosed Condition? A Literature Review

Pediatric Thyroid Cancer in Europe: An Overdiagnosed Condition? A Literature Review

Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident

Thyroid Cancer in Children of Eastern Anatolia

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