Thyroid Autotransplantation Following Total Thyroidectomy Restores Function in Mice

Charous, Daniel D; Heffelfinger, Ryan; Ambro, Bryan T.; Pribitkin, Edmund A.; Keane, William M.; Rothstein, Jay L.

doi:10.1016/j.otohns.2004.06.333

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The surgical procedures used for the treatment of thyroid disease vary considerably. Subtotal thyroidectomy or lobectomy have been performed for less aggressive or low-risk variants of follicular carcinoma, but several groups worldwide have always recommended total thyroidectomy because of its multicentricity and unpredictable prognosis (28). Total thyroidectomy performed in the presence of malignant neoplasms, or even multinodular toxic goiter, will certainly require postoperative hormone replacement.…”

Section: Figure 3 | (A)mentioning

confidence: 99%

Cryopreserved Rat Thyroid Autotransplantation in the Treatment of Postoperative Hypothyroidism

et al. 2021

View full text Add to dashboard Cite

To verify the viability and functionality of cryopreserved thyroid autotransplantation in rats who underwent total thyroidectomy in the treatment of postoperative hypothyroidism. Thirty-two Wistar rats were randomly assigned into groups (G) with eight animals each: control (CG); simulation (SG); hypothyroidism (HTG) and transplanted (TG). At the beginning and in the 13th week of the experiment, serum levels of total T3, free T4, TSH and calcium were determined. In both the first and 14th weeks, scintigraphic examinations, 99m-Tc pertechnetate radioisotope biodistribution and histopathology were performed. In the 14th week, the expression of proliferating cell nuclear antigen (PCNA) and cellular apoptosis (caspase-3) were also evaluated. In the 13th week, the transplanted animals had normal serum levels of total T3 and free T4. TSH levels showed a tendency towards normality. In the 14th week, scintigraphic exams displayed graft isotopic uptake in all animals in the TG group. Histological examinations 13 weeks after transplantation showed the viability and functionality of thyroid follicles. PCNA revealed significant immunoreactivity of the graft (p < 0.001) when the TG was compared to the CG. There was no difference between CG and TG considering the expression of activated caspase-3. The experimental study confirmed the viability and functionality of thyroid autotransplantation implanted in skeletal muscle with evidence of cell proliferation without cellular apoptosis. This surgical strategy was effective in the treatment of postoperative hypothyroidism.

show abstract

Section: Figure 3 | (A)mentioning

confidence: 99%

Cryopreserved Rat Thyroid Autotransplantation in the Treatment of Postoperative Hypothyroidism

et al. 2021

View full text Add to dashboard Cite

show abstract

Metastatic squamous cell carcinoma in autotransplanted thyroid: A diagnostic dilemma

Mallya

Narayan

Jain

2018

Indian J Pathol Microbiol

View full text Add to dashboard Cite

Metastasis to the thyroid is uncommon. Mostly, they are tumors that originate in the lung or head or neck. Metastases from breast or kidney carcinomas and metastatic melanoma have also been reported. Autotransplantation of benign thyroid tissue is a surgical procedure designed to achieve normal thyroid hormonal status following surgery. Metastasis into autotransplanted thyroid tissue has not been reported earlier. We report a case of squamous cell carcinoma (SCC) metastatic to autotrasplanted thyroid diagnosed on fine-needle aspiration. Further workup revealed a primary oral cavity SCC.

show abstract

Thyroid Autotransplantation Following Total Thyroidectomy Restores Function in Mice

Cited by 2 publications

References 0 publications

Cryopreserved Rat Thyroid Autotransplantation in the Treatment of Postoperative Hypothyroidism

Cryopreserved Rat Thyroid Autotransplantation in the Treatment of Postoperative Hypothyroidism

Metastatic squamous cell carcinoma in autotransplanted thyroid: A diagnostic dilemma

Contact Info

Product

Resources

About