Thyroid autotransplantation after total thyroidectomy in multi-nodular goiter—a case series analysis

Monib, Sherif; Habashy, Hany; Ibrahim, Mohamed

doi:10.1007/s12262-021-02719-z

Cited by 3 publications

(10 citation statements)

References 14 publications

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“…Also, these reports were clustered according to their geographical distribution. In Figure 7 , it is possible to observe the geographical distribution of the studies, half of which were conducted in the US and Middle East [ 2 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 70 ]. The sample size for the most numerous study is over 240 patients.…”

Section: Resultsmentioning

confidence: 99%

“…The studies entailed patients affected by benign thyroid disease. Specifically, thirteen studies focused on the treatment of lingual ectopy [ 2 , 3 , 46 , 47 , 48 , 49 , 50 , 51 , 57 , 58 , 59 , 60 , 61 , 62 ]; six studies were about patients with multinodular goiter [ 52 , 53 , 54 , 55 , 62 , 70 ]; six studies were carried out on patients with Graves’ disease [ 16 , 17 , 54 , 56 , 63 , 64 , 69 ]; a study on Hashimoto’s thyroiditis [ 54 , 69 ]; two studies on nodular goiter [ 54 , 56 , 69 ]; a study on unspecified postsurgical hypothyroidism [ 15 ] and a study on patients with thyrotoxicosis [ 65 ]. The heterograft sites are known in 23 out of 25 cases.…”

Section: Resultsmentioning

confidence: 99%

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Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Spinelli,

Ghionzoli,

Sahli

et al. 2024

Cancers

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Background and aims: This paper aims to study an alternative solution to hormonal replacement therapy in specific groups of patients who underwent thyroidectomy during childhood or adulthood. After cryopreservation, thyroid autotransplantation could be an alternative solution which would allow us to use the ability of the thyroid tissue of producing hormones according to the physiological needs of the body. Materials and methods: A feasibility study about the effects of the most modern cryopreservation techniques on the structural and functional integrity of the follicular cells of the thyroid tissue has been carried out. Patients who could benefit from the treatment have been found for both autotransplant techniques. Additionally, a literature review has been conducted. Results: The histological analysis has shown that cryopreservation does not alter the original architecture, and the culture examination that cell viability is successfully preserved. Moreover, both thyroid autotransplantation studies on animals and those on humans that were found in the literature have shown good results regarding the viability and functionality of the transplant. Conclusions: The viability of cryopreserved thyroid tissue found in this study is encouraging. Further studies to evaluate the levels of FT3, FT4 and thyroglobulin in thyroid tissue after cryopreservation are needed to verify that the secretory properties of the thyrocytes have been maintained intact. Furthermore, autotransplanted cases found in the literature do not have a long-term follow-up.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Spinelli,

Ghionzoli,

Sahli

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…The limited success could impute the poor integration with the host tissue, low survival rates, slow functional recovery, and others. [15,16] The key to restoring thyroid functions is maintaining the structure of thyroid follicles, which are the unique characteristics of this gland and responsible for the core functions of hormone synthesis and storage. [17] They rapidly release hormones in response to thyroid-stimulating signals and constitute the thyroid's feedback control system.…”

Section: Introductionmentioning

confidence: 99%

“…These studies mainly chose muscles or subcutaneous sites for transplantation. [ 15 ] Nonetheless, these regenerative strategies did not yet yield satisfactory outcomes. The limited success could impute the poor integration with the host tissue, low survival rates, slow functional recovery, and others.…”

Section: Introductionmentioning

confidence: 99%

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Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice

Tian,

Yin,

et al. 2023

Advanced Science

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Surgical removal of the thyroid gland (TG) for treating thyroid disorders leaves the patients on lifelong hormone replacement that partially compensates the physiological needs, but regenerating TG is challenging. Here, an approach is reported to regenerate TG within the spleen for fully restoring the thyroid's functions in mice, by transplanting thyroid tissue blocks to the spleen. Within 48 h, the transplanted tissue efficiently revascularizes, forming thyroid follicles similar to the native gland after 4 weeks. Structurally, the ectopically generated thyroid integrates with the surrounding splenic tissue while maintaining its integrity, separate from the lymphatic tissue. Functionally, it fully restores the native functions of the TG in hormone regulation in response to physiological stimuli, outperforming the established method of oral levothyroxine therapy in maintaining systemic homeostasis. The study demonstrates the full restoration of thyroid functions post‐thyroidectomy by intrasplenic TG regeneration, providing fresh insights for designing novel therapies for thyroid‐related disorders.

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Implantation of thyroid tissue after total thyroidectomy in quadriceps femoris muscle

Aly,

Hassanin,

Eldin Abu Elnga Ahmed

et al. 2024

The Egyptian Journal of Surgery

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Background It appears to be relatively simple to control postoperative hypothyroidism after total thyroidectomy (TT) with L-T4 replacement therapy, but from the patient’s perspective, a daily reliance on L-T4 administration and regular follow-up visits to the hospital may become somewhat of a burden and may interfere with reaching euthyroid status utilizing replacement therapy because of patient noncompliance. Aim and objectives To evaluate implantation of thyroid tissue in the thigh muscle after TT for benign simple nodular goiter to avoid lifelong use of thyroid hormones as replacement therapy and preservation of autoregulatory mechanism of thyroid hormone production. Patients and methods From April 2021 to September 2022, with approval from the Ethics Committee of the Faculty of Medicine at Assiut University, Assiut, Egypt, 40 individuals with simple nodular goiter who required TT participated in a prospective case series study. Results There was significant relation between 12 months follow up thyroid-stimulating hormone (TSH) levels and preoperative TSH levels. There was significant relation between 12 months follow up free T4 levels and preoperative TSH levels. Conclusion When performed on individuals who have benign thyroid disorders, TT is followed by autotransplantation of the patient’s own thyroid tissue. This technique is safe, straightforward, and applicable, and it results in a postoperative euthyroid state in the vast majority of carefully selected individuals without the need for additional replacement therapy.

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Thyroid autotransplantation after total thyroidectomy in multi-nodular goiter—a case series analysis

Cited by 3 publications

References 14 publications

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Cryopreserved Thyroid Tissue Autotransplant in Pediatric Age Patients: A Feasibility Study and Literature Review

Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice

Implantation of thyroid tissue after total thyroidectomy in quadriceps femoris muscle

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