2013
DOI: 10.1007/s00125-013-2934-9
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Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents

Abstract: Aims/hypothesis The aim of this work was to investigate, in children newly diagnosed with type 1 diabetes: (1) the prevalence of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb); and (2) the association between TPOAb, TGAb or both, with either islet autoantibodies or HLA-DQ genes. Methods Blood samples from 2,433 children newly diagnosed with type 1 diabetes were analysed for TPOAb and TGAb in addition to autoantibodies against arginine zinc transporter 8 (ZnT8RA), tryptophan zinc tra… Show more

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Cited by 39 publications
(38 citation statements)
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“…Additionally, it has long been recognized that positive AchRAb is synonymous with the onset of OMG [36]. Furthermore, as to HLA-DQ polymorphism, a result consistent with ours has also been reported by Jonsdottir et al [37] that HLA-DQ is associated with positive T-Ab, further supporting our findings. However, despite the discovery of correlation between HLA-DQ and positive T-Ab in patients with TAO-combined OMG, we failed to figure out the mechanism behind it, which awaits further studies to elucidate it.…”
Section: Discussionsupporting
confidence: 93%
“…Additionally, it has long been recognized that positive AchRAb is synonymous with the onset of OMG [36]. Furthermore, as to HLA-DQ polymorphism, a result consistent with ours has also been reported by Jonsdottir et al [37] that HLA-DQ is associated with positive T-Ab, further supporting our findings. However, despite the discovery of correlation between HLA-DQ and positive T-Ab in patients with TAO-combined OMG, we failed to figure out the mechanism behind it, which awaits further studies to elucidate it.…”
Section: Discussionsupporting
confidence: 93%
“…To our knowledge, this is the first study to prove that a strong relationship exists between the presence of these two autoantibodies (ZnT8A and ATPO) in newly diagnosed diabetic adult patients. Independently, in a large population of children with new onset of T1DM, Jonsdottir et al (29) discovered that both types of thyroid autoantibodies (ATPO and anti-thyroglobulin antibodyATg) were associated with GADA and ZnT8A. Zinc modulates the expression of many genes within the immune cells and is an essential element for immune function.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, there is heterogeneity in the natural history of AITD in patients with type 1 diabetes: AITD may be diagnosed either at diabetes onset or during the follow-up, and the measurement of TPOAb and TGAb is useful to predict the development of future AITD. We and others have previously reported the association between anti-thyroid autoimmunity and antiislet autoantibodies, especially glutamic acid decarboxylase 65 autoantibodies (GAD65A) and zinc transporter 8 autoantibodies (ZnT8A) [4][5][6][7] . The levels and the prevalence of GAD65A are higher and more persistent in type 1 diabetic patients with AITD compared to type 1 diabetes alone [4] .…”
Section: Introductionmentioning
confidence: 99%