Thyroid autoimmunity in patients with recurrent spontaneous miscarriages

Dendrinos, S.; Papasteriades, C.; Tarassi, Katerina; Christodoulakos, George; Prasinos, G; Creatsas, George

doi:10.3109/09513590009167693

Cited by 69 publications

(37 citation statements)

References 22 publications

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“…The studies differed in various aspects. Some had followed a cohort (235)(236)(237)248,250,252,253,(260)(261)(262)(263)(264)(265)(266)(267)(268)(269)(270)(271) (B,A,B,B,B,B,B,A,B-B) and others were "case-controlled" studies (251,254,(272)(273)(274)(275) (C,C,C,C,C).…”

Section: What Is the Role Of Thyroid Autoimmunity In Fertility And Prmentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

124

123

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Introduction: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. Objectives: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. Materials and methods: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. Results: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. Conclusions: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given. Arq Bras Endocrinol Metab. 2013;57(4):265-99

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Section: What Is the Role Of Thyroid Autoimmunity In Fertility And Prmentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

124

123

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“…These mainly occur, due to iodine deficiency of maternal auto-antibodies, can be raised against TSH receptor, regiment and autoimmunity, which is called Hashimato, peroxides enzyme and thyroglobulin itself. Due to the thyroiditis, low birth weight and mental retardation are above facts, the thyroid auto-antibodies maternal serum part of hypothyroidism side effect (Dendrinos et al, 2000; concentration should be assessed to diagnose the Glinoer, 2000;Netto et al, 2004). Grave disease, which may be responsible for metabolic disorder during pregnancy, mainly of hyperemesis Thyroid hormone assessment in hyperthyroidsm and gravidarum, by checking the serum level of thyroid hypothyroidism: Also clinical manifestation detected by auto-antibodies (Weetman and McGregor, 1984; the clinician is vital, but medical diagnostic laboratory can Fausett and Branch, 2000).…”

Section: During Pregnancymentioning

confidence: 99%

Thyroid Function Tests During First-trimester of Pregnancy: A Review of Literature

Mansourian¹

2010

Pakistan J. of Biological Sciences

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This literature review was conducted to summarize the main points of maternal thyroid function tests, with particular attention in the first trimester of pregnancy which accompanied with significant biochemical and metabolic alteration. The evaluation of thyroid function of either hyperthyroidism and hypothyroidism should be assessed by determination of serum Thyroid Stimulating Hormone (TSH), Thyroxine (T4), Triiodothyronine (T3), Iodine and Thyroid Autoantibodies. Glomerular filtration rate is increased during pregnancy; therefor iodine deficiency should be evaluated during the pregnancy to prevent hypothyroidism. The role which can be played by Human Chronic Gonadotropin (hCG) on stimulating the thyroid gland to become over-active was investigated. Serum level of thyroglobulin (Tg) and Thyroxin Binding Globulin (TBG) should be assessed for proper assessments of thyroid gland during pregnancy. Thyroid function tests during first-trimester of pregnancy and particularly the reference interval for thyroid function tests for pregnant women in each region has to be established, to prevent mis-diagnosis and irreversible mental and physical adverse affect for growing fetus.

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“…This first study on the association between miscarriage and thyroid autoimmunity was rapidly followed and confirmed by other controlled studies [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. In 2004, Prummel and Wiersinga [29] performed a metaanalysis of 18 controlled studies (eight case-control studies [12][13][14][15][16][17][18][19] and ten prospective [11,[20][21][22][23][24][25][26][27][28]) performed since 1990 when the association was first described. For all the studies, the authors have calculated the odds ratio (OR) with 95% confidence interval (95% CI) according to Sanderocock [30].…”

Section: Thyroid Autoimmunity and Pregnancy Lossmentioning

confidence: 78%

The Role of NK Cells in the Autoimmune Thyroid Disease-associated Pregnancy Loss

Konova

2010

Clinic Rev Allerg Immunol

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Pregnancy loss is a frequent event. Autoimmune thyroid disorders and altered natural killer (NK) cell functions are two distinct risk factors, which independently could induce adverse pregnancy outcome. Thyroid autoimmunity has been an object of increased attention by investigators in the context of pregnancy loss. Peripheral NK cells and uNK cells comprise distinct cell populations in terms of phenotype and function but they play an important role in the course of a normal human pregnancy via several potential functions. In autoimmune thyroid diseases, several abnormalities of killer cell activity have been described. The functional defects involving NK maturation and/or functional activation observed in Graves' disease patients could independently influence the reproductive outcome. This suggestion needs extensive investigation and could be important for the therapeutical approach in preventing pregnancy loss in patients with thyroid autoimmunity.

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Thyroid autoimmunity in patients with recurrent spontaneous miscarriages

Cited by 69 publications

References 22 publications

Clinical practice guidelines for the management of hypothyroidism

Clinical practice guidelines for the management of hypothyroidism

Thyroid Function Tests During First-trimester of Pregnancy: A Review of Literature

The Role of NK Cells in the Autoimmune Thyroid Disease-associated Pregnancy Loss

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