Thyroid Autoimmunity in Children and Adolescents with Type 1 Diabetes mellitus

Holl, Reinhard W.; Böhm, Bernhard; Loos, U.; Grabert, M.; Heinze, E.; Homoki, J.

doi:10.1159/000023446

Cited by 86 publications

(72 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, in the general population without diabetes, the prevalence of positive test results for thyroid antibodies has been found to increase with age (9). As in previous studies (6,10), female subjects were significantly predisposed to thyroid autoimmunity at any age. Although it is unlikely that association between age or sex and antibody positivity may not exist in the total cohort, we cannot exclude this possibility, because the subset of patients studied was not randomly selected.…”

Section: Resultssupporting

confidence: 53%

Thyroid Autoimmunity in Children and Adolescents With Type 1 Diabetes

Kordonouri

Klinghammer²,

Lang³

et al. 2002

Diabetes Care

265

160

View full text Add to dashboard Cite

OBJECTIVE -To investigate thyroid autoimmunity in a very large nationwide cohort of children and adolescents with type 1 diabetes.RESEARCH DESIGN AND METHODS -Data were analyzed from 17,749 patients with type 1 diabetes aged 0.1-20 years who were treated in 118 pediatric diabetes centers in Germany and Austria. Antibodies to thyroglobulin (anti-TG) and thyroperoxidase (anti-TPO) were measured and documented at least once in 7,097 patients. A total of 49.5% of these patients were boys, the mean age was 12.4 years (range 0.3-20.0 years), and the mean duration of diabetes was 4.5 years (range 0.0 -19.5 years). A titer exceeding 100 units/ml or 1:100 was considered significantly elevated.RESULTS -In 1,530 patients, thyroid antibody levels were elevated on at least one occasion, whereas 5,567 were antibody-negative during the observation period. Patients with thyroid antibodies were significantly older (P Ͻ 0.001), had a longer duration of diabetes (P Ͻ 0.001), and developed diabetes later in life (P Ͻ 0.001) than those without antibodies. A total of 63% of patients with positive antibodies were girls, compared with 45% of patients without antibodies (P Ͻ 0.001). The prevalence of significant thyroid antibody titers increased with increasing age; the highest prevalence was in the 15-to 20-year age group (anti-TPO: 16.9%, P Ͻ 0.001; anti-TG: 12.8%, P Ͻ 0.001). Thyroid-stimulating hormone (TSH) levels were higher in patients with thyroid autoimmunity (3.34 U/ml, range 0.0 -615.0 U/ml) than in control subjects (1.84 U/ml, range 0.0 -149.0 U/ml) (P Ͻ 0.001). Even higher TSH levels were observed in patients with both anti-TPO and anti-TG (4.55 U/ml, range 0.0 -197.0 U/ml).CONCLUSIONS -Thyroid autoimmunity seems to be particularly common in girls with diabetes during the second decade of life and may be associated with elevated TSH levels, indicating subclinical hypothyroidism.

show abstract

Section: Resultssupporting

confidence: 53%

Thyroid Autoimmunity in Children and Adolescents With Type 1 Diabetes

Kordonouri

Klinghammer²,

Lang³

et al. 2002

Diabetes Care

265

160

View full text Add to dashboard Cite

show abstract

“…In a study performed in Thailand anti-TPO antibodies were detected 30% in 50 T1D cases and the frequencies were higher in females (27). A study in Giessen demonstrated higher thyroid autoimmunity in girls with T1D and the positive correlation with age (28). Many other studies also found higher prevalences of thyroid autoimmunity in T1D patients (29,30).…”

Section: Discussionmentioning

confidence: 93%

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

Erten¹,

Gürol²,

Deniz³

et al. 2007

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

Type 1 diabetes mellitus (T1D) patients (G1; n=73) and first degree relatives with of FPIR (G2; n=18) were screened for two other autoantibodies, anti-glutamic acid decarboxylase (GADA) and insulin autoantibodies (IAA), and for other organ-specific autoantibodies, anti-gastric parietal cell (anti-PCA) and anti-thyroid peroxidase (anti-TPO) as well. The two control groups consisted of healthy subjects (G3; n:55 and G4; n:13). In G1, positivity of ICA, GADA, IAA, anti-TPO and anti-PCA were 63%, 75.1%, 27.4%, 17.8% and 8.2%, respectively. In G2, positivity for GADA, IAA, anti-TPO and anti-PCA were 55.6%, 11.1%, 16.7% and 11.1%, respectively. None of the anti-TPO or anti-PCA positive cases had clinical or laboratory thyroid disease or pernicious anemia.Other organ specific antibodies, in case they accompany GADA and/or IAA in high risk individuals, result in higher risk for T1D. Moreover, this condition may indicate future potential for developing thyrogastric autoimmune diseases.In conclusion; autoantibodies are markers for autoimmune destruction in T1D, and for identification of subjects at risk for disease. Even at the time of diagnosis of T1D, screening for thyrogastric autoimmunity might be recommended for early detection of the relevant diseases.

show abstract

“…In particular, autoimmune thyroid disease (AITD) (Graves' disease and Hashimoto thyroiditis associated with hyper-and hypothyroidism, respectively) and autoimmune type 1 diabetes are often diagnosed in the same subjects [1,2,4,9,10].…”

mentioning

confidence: 99%

“…In addition to associations with HLA class II alleles and haplotypes, notably DRB1*03-DQB1*02 [10][11][12], and the lymphoid-specific phosphatase T cell activation gene, protein tyrosine phosphatase non-receptor type 22 (lymphoid) (PTPN22) [13], AITD and type 1 diabetes have been associated with the cytotoxic T-lymphocyte-associated antigen-4 gene (CTLA4) [5], which encodes a vital negative immunoregulatory receptor in T cell activation and expansion. The association with AITD is strong (odds ratio [OR] ∼1.5) with single nucleotide polymorphisms (SNPs) in the 3′UTR of the gene being the strongest candidates for the causal variant(s) [14].…”

mentioning

confidence: 99%

A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene

et al. 2007

View full text Add to dashboard Cite

Aims/hypothesis HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and of the T cell activation gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) have been associated with type 1 diabetes and autoimmune thyroid disease. Using thyroid peroxidase autoantibodies (TPOAbs) as an indicator of thyroid autoimmunity, we assessed whether the association of these loci is different in type 1 diabetes patients with TPOAbs than in those without. Materials and methods TPOAbs were measured in 4,364 type 1 diabetic patients from across Great Britain, 67% of whom were aged under 18 years. These patients and 6,866 geographically matched control subjects were genotyped at CTLA4, PTPN22, HLA-DRB1 and HLA-DQB1. Results TPOAbs were detected in 462 (10.6%) of the type 1 diabetic patients. These patients had a stronger association with CTLA4 (odds ratio [OR]=1.49 for the G allele of the single nucleotide polymorphism rs3087243; 95% CI=1.29-1.72) than did the TPOAbs-negative patients (p=0.0004; OR=1.16; 95% CI=1.10-1.24) or type 1 diabetes patients overall (OR=1.20; 95% CI=1.13-1.27). The ratio of women:men was higher (1.94:1) in this subgroup than in type 1 diabetes patients without TPOAbs (0.94:1; p=1.86× 10 −15

show abstract

Thyroid Autoimmunity in Children and Adolescents with Type 1 Diabetes mellitus

Cited by 86 publications

References 13 publications

Thyroid Autoimmunity in Children and Adolescents With Type 1 Diabetes

Thyroid Autoimmunity in Children and Adolescents With Type 1 Diabetes

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene

Contact Info

Product

Resources

About