Thyroid autoimmunity and its association with non-organ-specific antibodies and subclinical alterations of thyroid function in women with a history of pregnancy loss or preeclampsia

Mecacci, Federico; Parretti, Elena; Cioni, Riccardo; Lucchetti, Roberto; Magrini, Alessandra; Torre, Pasquale La; Mignosa, Marcella; Acanfora, Luisa; Mello, Giorgio

doi:10.1016/s0165-0378(99)00055-8

Cited by 57 publications

(35 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This first study on the association between miscarriage and thyroid autoimmunity was rapidly followed and confirmed by other controlled studies [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. In 2004, Prummel and Wiersinga [29] performed a metaanalysis of 18 controlled studies (eight case-control studies [12][13][14][15][16][17][18][19] and ten prospective [11,[20][21][22][23][24][25][26][27][28]) performed since 1990 when the association was first described. For all the studies, the authors have calculated the odds ratio (OR) with 95% confidence interval (95% CI) according to Sanderocock [30].…”

Section: Thyroid Autoimmunity and Pregnancy Losssupporting

confidence: 63%

The Role of NK Cells in the Autoimmune Thyroid Disease-associated Pregnancy Loss

Konova

2010

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Pregnancy loss is a frequent event. Autoimmune thyroid disorders and altered natural killer (NK) cell functions are two distinct risk factors, which independently could induce adverse pregnancy outcome. Thyroid autoimmunity has been an object of increased attention by investigators in the context of pregnancy loss. Peripheral NK cells and uNK cells comprise distinct cell populations in terms of phenotype and function but they play an important role in the course of a normal human pregnancy via several potential functions. In autoimmune thyroid diseases, several abnormalities of killer cell activity have been described. The functional defects involving NK maturation and/or functional activation observed in Graves' disease patients could independently influence the reproductive outcome. This suggestion needs extensive investigation and could be important for the therapeutical approach in preventing pregnancy loss in patients with thyroid autoimmunity.

show abstract

Section: Thyroid Autoimmunity and Pregnancy Losssupporting

confidence: 63%

The Role of NK Cells in the Autoimmune Thyroid Disease-associated Pregnancy Loss

Konova

2010

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

show abstract

“…The studies differed in various aspects. Some had followed a cohort (235)(236)(237)248,250,252,253,(260)(261)(262)(263)(264)(265)(266)(267)(268)(269)(270)(271) (B,A,B,B,B,B,B,A,B-B) and others were "case-controlled" studies (251,254,(272)(273)(274)(275) (C,C,C,C,C).…”

Section: What Is the Role Of Thyroid Autoimmunity In Fertility And Prmentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

124

123

View full text Add to dashboard Cite

Introduction: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. Objectives: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. Materials and methods: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. Results: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. Conclusions: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given. Arq Bras Endocrinol Metab. 2013;57(4):265-99

show abstract

“…Other antibodies such as those against thyroid components, nuclear antigens and deoxyribonucleic acid (DNA) fractions 2 have also been associated with gestational loss and preeclampsia. 3 Venous thrombosis in the mother has been associated with RSA in several series. 4,5 Acquired thrombophilia is associated with thrombophilic factors with no inherited characteristics, such as anticardiolipin antibody (ACA) and lupus anticoagulant (LA).…”

Section: Introductionmentioning

confidence: 99%

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

et al. 2005

View full text Add to dashboard Cite

RESULTS: ACA was detected in 11 women with RSA and one fertile woman. Heterozygous C677T was detected in 59 women with RSA and 35 fertile women. Concomitant presence of ACA and C677T was found in eight women with RSA and no fertile women (p < 0.01). DISCUSSION:The meaning of the association between C677T mutation in the MTHFR gene and ACA is still not clear. It is possible that an inherited factor that alone would not strongly predispose a woman to thrombosis could, when associated with an acquired factor, start the process and increase the likelihood of thrombosis expression.CONCLUSIONS: ACA and C677T in the MTHFR gene are statistically associated with RSA. The association of these two conditions is a new fi nding in thrombogenic factors and RSA.

show abstract

Thyroid autoimmunity and its association with non-organ-specific antibodies and subclinical alterations of thyroid function in women with a history of pregnancy loss or preeclampsia

Cited by 57 publications

References 19 publications

The Role of NK Cells in the Autoimmune Thyroid Disease-associated Pregnancy Loss

The Role of NK Cells in the Autoimmune Thyroid Disease-associated Pregnancy Loss

Clinical practice guidelines for the management of hypothyroidism

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

Contact Info

Product

Resources

About