Thyroid angiosarcoma (TAS) — A rare diagnosis not to be missed

Kehagias, Dimitrios; Kostopoulou, Eirini; Ravazoula, Panagiota; Panagopoulos, Konstantinos

doi:10.1002/ccr3.3492

Cited by 6 publications

(9 citation statements)

References 20 publications

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“…Thyroglobulin staining was negative. In the past, TAS was a controversial entity because it was considered a vascular mutation of anaplastic carcinoma and not a true sarcoma (3). However, according to the last World Health Organization (WHO) classification of tumors of endocrine organs, TAS is considered a distinct entity included in the group of vascular tumors (8).…”

Section: Discussionmentioning

confidence: 99%

“…T hyroid angiosarcoma is an extremely rare and highly aggressive malignant tumor. This entity constitutes less than 1% of all sarcomas, with a higher prevalence in alpine regions (1)(2)(3). This geographic variation might be associated with iodine deficiency and a long history of endemic goiter (1,3).…”

Section: Introductionmentioning

confidence: 99%

“…This entity constitutes less than 1% of all sarcomas, with a higher prevalence in alpine regions (1)(2)(3). This geographic variation might be associated with iodine deficiency and a long history of endemic goiter (1,3). Other factors, such as exposure to radiation and to vinyl chloride, have also been described as predisposing factors (3).…”

Section: Introductionmentioning

confidence: 99%

“…This geographic variation might be associated with iodine deficiency and a long history of endemic goiter (1,3). Other factors, such as exposure to radiation and to vinyl chloride, have also been described as predisposing factors (3). These tumors are more frequent in females (ratio 9:3) and occur mainly between 50 and 80 years of age (4).…”

Section: Introductionmentioning

confidence: 99%

“…These tumors are more frequent in females (ratio 9:3) and occur mainly between 50 and 80 years of age (4). The clinical manifestations of thyroid angiosarcoma are nonspecific and depend on the location, size, extension and existence of metastases (3). The prognosis is unfavorable, with a 5-year survival rate of 33.3%, because it tends to spread rapidly to the cervical lymph nodes, lungs and bone marrow (1,5).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Non-alpine primary thyroid angiosarcoma

Bala¹,

Simões²,

Aragüés³

et al. 2022

Archives of Endocrinology and Metabolism

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Thyroid angiosarcoma is an extremely rare malignancy, which occurs more frequently in the alpine region, likely associated with iodine deficiency and endemic goiter. This is an aggressive neoplasm that usually harbors a poor prognosis. We report the case of a 49-year-old Portuguese female patient presenting with a large nodule in the anterior neck region, with rapid growth and associated dysphonia. The neck ultrasound showed a hypoechogenic and heterogeneous thyroid nodule, with a larger axis of 44 mm. The fine needle aspiration cytology was not conclusive, and a biopsy of the lesion was performed. The result was suggestive of a mesenchymal tumor constituted by spindle cells and vascular clefts, showing positivity for endothelial markers and negativity for thyroglobulin, calcitonin and TTF1. The chest CT scan performed before surgery showed multiple pulmonary nodules suggestive of secondary lesions. The patient was submitted to total thyroidectomy and lymph node dissection in order to relieve compressive symptoms. A diagnosis of thyroid angiosarcoma was made after histologic examination of the surgical specimen. Despite undergoing multiple lines of palliative chemotherapy, the pulmonary lesions increased in size and number. The patient died due to respiratory failure 29 months after the diagnosis. Thyroid angiosarcoma is a rare malignancy, generally with poor prognosis. In our case, the patient presented with pulmonary metastases at diagnosis, which is a negative prognostic factor. Due to its rarity, data regarding management and treatment of this disease are scarce.

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Section: Discussionmentioning

confidence: 99%