Thyroid and other organ-specific autoantibodies in healthy ceritenarians

Mariotti, Stefano; Barbesino, Giuseppe; Caturegli, Patrizio; Giacomelli, Tamara; Pinchera, Aldo; Monti, Daniela; Cossarizza, Andrea; Franceschi, Claudio; Sansoni, Paolo; Passeri, Giovanni; Fagiolo, U

doi:10.1016/0140-6736(92)91265-a

Cited by 220 publications

(97 citation statements)

References 9 publications

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“…Lowered plasma thyroxine (T 4 ) and increased thyrotropinstimulating hormone (TSH) concentrations occur in 5 to 10% of elderly women (18). These abnormalities are mainly caused by autoimmunity and are therefore an expression of age-associated disease rather than a consequence of the aging process (19,20). Normal aging is accompanied by a slight decrease in pituitary TSH release (18), but especially by a decreased peripheral degradation of T 4 , which results in a gradual agedependent decline in serum triiodothyronine (T 3 ) concentration, without an important change in T 4 levels (21).…”

Section: Endocrinology Of Agingmentioning

confidence: 99%

The Endocrinology of Aging

Lamberts

Beld

Lely

1997

Science

871

409

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Most aging individuals die from atherosclerosis, cancer, or dementia; but in the oldest old, loss of muscle strength resulting in frailty is the limiting factor for an individual's chances of living an independent life until death. Three hormonal systems show decreasing circulating hormone concentrations during normal aging: (i) estrogen (in menopause) and testosterone (in andropause), (ii) dehydroepiandrosterone and its sulphate (in adrenopause), and (iii) the growth hormone/insulin-like growth factor I axis (in somatopause). Physical changes during aging have been considered physiologic, but there is evidence that some of these changes are related to this decline in hormonal activity. Hormone replacement strategies have been developed, but many of their aspects remain controversial, and increasing blood hormone levels in aging individuals to those found during mid-adult life has not been uniformly proven to be safe and of benefit.

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Section: Endocrinology Of Agingmentioning

confidence: 99%

The Endocrinology of Aging

Lamberts

Beld

Lely

1997

Science

871

409

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“…The same can be observed in centenarians in good health conditions, who have some types of immune response which are well preserved (Mariotti et al, 1992;Sansoni et al, 1993;Cossarizza et al, 1996;Candore et al, 1997;Bagnara et al, 2000;Listì et al, 2006).…”

Section: Ageing and Longevity: The Demographic Revolutionmentioning

confidence: 63%

The extreme longevity: The state of the art in Italy

Franceschi¹,

Motta²,

Motta³

et al. 2008

Experimental Gerontology

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“…At this point, can be possible that the presence of these regulatory cells might be responsible for controlling autoimmune phenomena (24), such as low levels of circulating autoantibodies, especially anti-thyroid, seen in centenarians (25).…”

Section: Discussionmentioning

confidence: 99%

TCR Vβ repertoire in an Italian longeval population including centenarians.

Pennesi

Morellini

Lulli

et al. 2001

AGE

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During the last years, the hypothesis that aging and diseases are two distinct phenomena, and that successful aging is possible for most humans, has been put forward.We studied the TCR VI3 repertoire of T lymphocytes of healthy Iongevals and centenarians as crossing point of genetic predisposition and environmental effects to longevity, using the Spectratyping method.TCR V~I, V~8, and VI~20 were found to be expanded in the Iongeval population, compared with the younger control population. This repertoire can have been shaped by the selective action of particular HLA alleles, or by the clonal expansion of specific T cell clones, able to modulate the immune response to endogenous and exogenous antigens. Moreover, the skewed V~ usage and the clonal expansion seem to be the effects of physiological changes occurring with aging and not pathological signs of malignity.

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Thyroid and other organ-specific autoantibodies in healthy ceritenarians

Cited by 220 publications

References 9 publications

The Endocrinology of Aging

The Endocrinology of Aging

The extreme longevity: The state of the art in Italy

TCR Vβ repertoire in an Italian longeval population including centenarians.

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