Thyroid: an Unusual Hideout for Sarcoidosis

Manchanda, Aarti; Patel, Shivani; Jiang, Jesse; Babu, Ambika

doi:10.4158/ep12131.cr

Cited by 19 publications

(8 citation statements)

References 18 publications

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“…Clinical history may be illuminating, as these cases classically present as a painful thyroid, preceded by a self‐limiting viral illness, with characteristic changes in thyroid function tests. Other granulomatous giant cell‐containing conditions of the thyroid include mycobacterial or fungal infections and sarcoidosis . These entities, in which the MGC may be abundant with numerous nuclei (up to 150) and foamy cytoplasm, typically identified alone or in association with granulomas, are rarely encountered in typical FNA practice .…”

Section: Discussionmentioning

confidence: 99%

What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast‐like giant cells involving the thyroid

et al. 2018

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Section: Discussionmentioning

confidence: 99%

What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast‐like giant cells involving the thyroid

et al. 2018

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“…9 Thyroid involvement can take the form of a nontoxic multinodular goiter or nontoxic nodules, and in cases of sarcoidosis of the thyroid gland, fine-needle aspiration cytology is frequently nondiagnostic or unhelpful. 3,4,10 Moreover, a combination of goiter or dominant nodule with coexisting cervical lymphadenopathy can lead to thyroid sarcoidosis either mimicking, or concealing, thyroid malignancy. 11,12 To the best of our knowledge, previous case reports of Graves' thyrotoxicosis exhibiting resistance to antithyroid treatment and RAI treatment, with a concomitant diagnosis of thyroid sarcoidosis, are rare.…”

Section: Discussionmentioning

confidence: 99%

“…2 Less than 10% of patients have hypercalcemia and hypercalciuria, predominantly due to extrarenal hydroxylation of vitamin D to the biologically active 1,25-dihydroxyvitamin D. 1,2 Thyroid involvement is rare and is seen in 1 to 4.6% of cases. 1,[3][4][5] We present a case of apparently isolated thyroid sarcoidosis manifesting as a cause of treatment-resistant Graves' thyrotoxicosis. This rare presentation of sarcoidosis is discussed on the background of current available evidence.…”

mentioning

confidence: 99%

Thyroid Sarcoidosis as a Rare Explanation of Resistance to Radioactive Iodine in Graves’ Disease

Scott‐Coombes¹,

Stechman²,

Egan³

et al. 2018

World Journal of Endocrine Surgery

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Background: Sarcoidosis is a multiorgan idiopathic inflammatory disease that involves the thyroid gland in 1 to 4.6% of the cases. Case report:We report a case of a 36-year-old man who was diagnosed with Graves' disease and initially treated with block and replace regimen followed by radioactive iodine (RAI), both of which were unsuccessful. The patient subsequently underwent an uncomplicated total thyroidectomy. Subsequent histological evaluation of the thyroid tissue demonstrated granulomatous inflammation consistent with a diagnosis of sarcoidosis. This was the index presentation of this diagnosis with no previous symptoms or clinical manifestations related to sarcoidosis. Conclusion:Using this case as an example, we therefore conclude that relative resistance of Graves' thyrotoxicosis to treatment may be due to a novel underlying presentation of sarcoidosis.Clinical significance: Sarcoidosis of the thyroid gland should be considered as part of the clinical differential diagnosis in cases of treatment-resistant thyrotoxicosis.

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“…A paper by Cabibi et al ( 34 ) reported the case of a 42 years old woman with sarcoidosis limited to the thyroid and adjacent small lymph nodes, without signs of systemic involvement or on other organs, showing thyroid nodules and normal biochemical levels and thyroid function parameters, and histologic sarcoid-type lesions, treated with thyroidectomy. Manchanda et al ( 35 ) described the case of a man aged 54 years with asymptomatic non-toxic thyromegaly. He had an acute onset of dysphagia but the examination for gastrointestinal causes was negative.…”

Section: Thyroid Autoimmunity and Sarcoidosismentioning

confidence: 99%

Sarcoidosis and Thyroid Autoimmunity

2017

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Most of the studies have shown a higher risk for subclinical and clinical hypothyroidism, antithyroid autoantibodies [overall antithyroid peroxidase antibodies (TPOAb)], and in general, thyroid autoimmunity, overall in the female gender in patients with sarcoidosis (S). A significantly higher prevalence of clinical hypothyroidism and Graves’ disease was also described in female S patients with respect to controls. Gallium-67 (Ga-67) scyntigraphy in S patients, in the case of thyroid uptake, suggests the presence of aggressive autoimmune thyroiditis and hypothyroidism. For this reason, ultrasonography and thyroid function should be done in the case of Ga-67 thyroid uptake. In conclusion, thyroid function, TPOAb measurement, and ultrasonography should be done to assess the clinical profile in female S patients, and the ones at high risk (female individuals, with TPOAb positivity, and hypoechoic and small thyroid) should have periodically thyroid function evaluations and suitable treatments.

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Thyroid: an Unusual Hideout for Sarcoidosis

Cited by 19 publications

References 18 publications

What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast‐like giant cells involving the thyroid

What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast‐like giant cells involving the thyroid

Thyroid Sarcoidosis as a Rare Explanation of Resistance to Radioactive Iodine in Graves’ Disease

Sarcoidosis and Thyroid Autoimmunity

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