Thyroglossal Duct Cyst Papillary Carcinoma With Airway Compromise

Huang, Po-Kai; Hsieh, Li‐Chun; Leu, Yi-Shing

doi:10.1177/01455613211022077

Cited by 6 publications

(8 citation statements)

References 10 publications

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“…There is a strong debate about the origin of TDC carcinomas. The etiology is explained by either de novo theory or metastatic theory [ 13 ]. Currently, most authors support the de novo theory, which is based on the carcinogenesis of ectopic thyroid tissue within the cyst and the absence of metastatic disease [ 3 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical presentation and characteristics of a TDC carcinoma are generally indistinguishable from benign TDCs [ 8 , 13 ], making the preoperative diagnosis challenging [ 8 , 27 ]. A detailed clinical history is essential for an accurate diagnosis before surgery [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Identifying a TDC carcinoma is generally indistinguishable from benign tumors preoperatively [ 8 , 13 ]. Currently, there is no established consensus on TDC malignancy treatment, especially in adolescents [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case Report of Thyroglossal Duct Cyst Carcinoma Coexisting with Thyroid Carcinoma in an Adolescent

Mylopotamitaki,

Klonaris,

Kazamias

et al. 2023

Case Reports in Otolaryngology

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Background. Thyroglossal duct cysts (TDC) represent approximately 70% of all congenital neck masses, and up to 1% of them contain thyroid tissue malignancies. Clinical presentation of TDC carcinomas is usually indistinguishable from benign tumors preoperatively, and differential diagnosis can be challenging. We present a rare case of TDC carcinoma concurrent with thyroid cancer in an adolescent. Case Presentation. A 16-year-old Caucasian female, otherwise healthy, was referred with a painless, gradually expanding lump on the neck. Physical examination revealed a well-circumscribed, moderately hard, tender mass of the anterior neck midline anteroinferior to the hyoid bone. Imaging findings suggested TDC as the most likely diagnosis. The patient had a Sistrunk procedure under general anesthesia. Histopathological findings diagnosed a BRAFV600E-positive papillary thyroid carcinoma (PTC) in a TDC. A thyroid gland and neck ultrasound revealed a highly suspicious finding for malignancy right level VI lymph node, which was not confirmed by fine needle aspiration cytology (FNAC). Under general anesthesia, total thyroidectomy and central compartment lymph node neck dissection were performed. Histopathological findings revealed a thyroid parenchymal locus of PTC, as well as three lymph nodes infiltrated by PTC. The patient received adjuvant radioactive iodine ablation (RAI) therapy and is closely followed. Conclusion. TDC carcinomas in conjunction with thyroid carcinomas in young patients are rare. Preoperative diagnosis can be challenging, as the vast majority of neck masses in young patients are benign in nature, and most malignant tumors lack specific clinical features. The diagnostic accuracy of FNAC is considered unsatisfactory due to its frequently cystic nature. Definitive diagnosis is based on histopathological findings. Clinicians should maintain a high level of suspicion for coexisting thyroid malignancies. Although surgical extirpation of the malignancy is considered standard of care, the treatment of TDC cancer should always be individualized by a multidisciplinary team.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Rare Case Report of Thyroglossal Duct Cyst Carcinoma Coexisting with Thyroid Carcinoma in an Adolescent

Mylopotamitaki,

Klonaris,

Kazamias

et al. 2023

Case Reports in Otolaryngology

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“…For instance, the presence of overlying skin fixity in a thyroid nodule is almost always suggestive of malignant neoplasm, but such finding in an otherwise inconspicuous TDC is mostly attributed to the past infection and scarring/fibrosis. Similarly, some of the other warning signs such as, dysphonia, stridor or dysphagia, that generally imply malignancy in thyroid nodule could be seen even in non-malignant TDC with unusual location and extension, rendering them non-reliable for predicting malignancy in TDC 22–25. Of all the signs and symptoms, the presence of a suspicious cervical lymph node is probably the most reliable clinical finding to suggest a possible malignant pathology inside the TDC, but the incidence of metastatic cervical lymphadenopathy in TDCC is only around 10%–15% 6 8 11…”

Section: Discussionmentioning

confidence: 99%

Synchronous carcinoma of thyroglossal duct cyst and native thyroid gland

et al. 2022

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The unobliterated portion of embryological thyroglossal duct may present as cystic swelling later in life and may contain functional thyroid follicles. This cyst requires excision along with the entire thyroglossal duct remnant and adjacent portion of hyoid bone. At times, the excised specimen could demonstrate a focus of carcinomatous change inside the cyst wall. Very rarely, this thyroglossal duct cyst carcinoma could be associated with malignancy of native thyroid gland. This case report illustrates an interesting case of synchronous carcinoma of thyroglossal duct cyst and native thyroid gland. It also sheds light on the controversies related to the pathophysiology of such association and the dilemmas surrounding the management of thyroglossal duct cyst carcinoma, with or without concurrent carcinoma of thyroid gland.

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“…Only about 3% of the patients complain of dysphagia and pain. TGDC carcinoma can arise from the thyroid tissue of the cyst; Therefore, the most common primary TGDC carcinoma is papillary thyroid cancer (in more than 90% of cases) [5]. The reference surgical technique for TGDC is Sistrunk's procedure which comprises resection of the body of the hyoid bone.…”

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confidence: 99%