Thyroglossal duct cyst carcinoma with concurrent thyroid carcinoma: a case report

Gebbia, Vittorio; Gregorio, Carlo Di; Attard, Marco

doi:10.1186/1752-1947-2-132

Cited by 19 publications

(22 citation statements)

References 12 publications

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“…21 The primary management of the thyroglossal duct carcinoma is still controversial, regarding the management of thyroid gland along with thyroglossal gland. 20 While some authors consider only Sistrunk procedure as the primary management but others consider including total or near-total thyroidectomy in the management of thyroglossal duct carcinoma. 22 The rationale for thyroidectomy to be included in the thyroglossal cyst carcinoma is based on: presence of occult primary in thyroid gland proper, use of radioactive iodine as an adjuvant treatment, and role of thyroglobulin as a serum marker for post-operative follow-up.…”

Section: Pathological Discussionmentioning

confidence: 99%

Papillary Carcinoma Thyroid in Thyroglossal Cyst- A Case Report

Rao¹,

Rao²,

Kumar³

et al. 2019

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Section: Pathological Discussionmentioning

confidence: 99%

Papillary Carcinoma Thyroid in Thyroglossal Cyst- A Case Report

Rao¹,

Rao²,

Kumar³

et al. 2019

jebmh

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“…Although the diagnosis of thyroglossal duct carcinoma is based on the pathologic examination of the mass in general, needle aspiration cytology, ultrasound, and computed tomography play a role in the differential diagnosis of malignancy . According to Luna‐Ortiz et al the thyroglossal duct cyst must be studied in adult population by fine‐needle aspiration biopsy (FNAB) and by frozen section in cases in which FNAB is inconclusive or unavailable.…”

Section: Discussionmentioning

confidence: 99%

“…Contemporary appearance of thyroid carcinoma has been described in about 20% of thyroglossal duct carcinomas. 21 However, such reports are occasional in the published literature 11,22 and the thyroidectomy specimen following Sistrunk procedure for thyroglossal duct carcinoma does not always reveal malignancy. 17,23 The thyroidectomy specimen in our case did not reveal malignancy, but one thing is certain, the FNA cytodiagnosis of this rare case of papillary carcinoma in thyroglossal duct cyst led us to the review of paraffin sections and the histopathological diagnosis had to be changed.…”

Section: Discussionmentioning

confidence: 99%

“…Papillary carcinoma in thyroglossal duct cyst with positive reaction for thyroglobulin and cytokeratin 19 has been reported earlier 10. Although the diagnosis of thyroglossal duct carcinoma is based on the pathologic examination of the mass in general, needle aspiration cytology, ultrasound, and computed tomography play a role in the differential diagnosis of malignancy 11. According to Luna-Ortiz et al12 the Papillary thyroid carcinoma in a thyroglossal duct cyst: FNA smear from a midline upper neck swelling in a 36-year-old man.…”

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confidence: 99%

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Papillary carcinoma in thyroglossal duct cyst: Diagnosis by fine‐needle aspiration cytology and immunocytochemistry

Das

George

Mohammad

et al. 2018

Diagnostic Cytopathology

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Carcinoma associated with thyroglossal duct cyst (TDC) is extremely rare and when it occurs it is invariably papillary carcinoma. A 36-year-old man presented with a midline swelling in the upper part of neck, which was a cystic lesion with multiple septae in ultrasonogram, indicating a thyroglossal duct cyst. The CT scan findings also corroborated the ultrasound report. Fine needle aspiration (FNA) smears showed hemosiderin laden cyst macrophages and occasional papillary cluster of neoplastic cells with central psammoma body and rare intranuclear cytoplasmic inclusions. The neoplastic cells revealed positive reaction for thyroglobulin, galectin3, and CD44. FNA cytodiagnosis was thyroglossal duct cyst with cytologic features suggestive of papillary carcinoma. The histopathological diagnosis of the resected lesion, however, was metastatic papillary thyroid carcinoma in lymph node with cystic changes; there was positive reaction for thyroglobulin, galectin3, HBME1, and CK. Following this histopathology report, thyroidectomy was performed, which revealed lymphocytic thyroiditis and no evidence of papillary carcinoma. Review of paraffin sections of upper midline neck mass showed a cavity bound by thick fibrocollageneous wall and lined partly by epithelium consistent with papillary carcinoma. The cyst wall showed dense lymphomononuclear cell infiltration and germinal center formation. There were foci of papillary carcinoma in the cyst wall with frequent nuclear grooves, cerebriform nuclei and intranuclear cytoplasmic inclusions. The reviewed histopathological diagnosis was consistent with papillary carcinoma in thyroglossal duct cyst. Thus, the FNA cytodiagnosis of a rare case of papillary carcinoma in thyroglossal duct cyst, led to review and change in histopathological diagnosis achieving cyto-histopathological correlation.

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“…Known concurrent associations with TGDCs in the literature include sublingual/lingual thyroid,33 34 epidermoid cyst,35 thyroid carcinoma,36 37 fistula,5 inferior parathyroid cyst38 and lingual tonsil hypertrophy 39…”

Section: Discussionmentioning

confidence: 99%

A rare case of a concurrent large thyroglossal duct cyst with a base of tongue haemangioma

McNamara

Olaleye²,

Smith³

et al. 2011

Case Reports

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An 85-year-old lady presented with a large midline neck mass. After 8 years of steady growth, the previously asymptomatic mass began to cause stridor and dysphagia. The patient's comorbidities included a previous partial glossectomy for haemangioma of the tongue, chronic obstructive pulmonary disease, congestive cardiac failure and obesity (body mass index >30). CT neck revealed the midline mass was cystic in nature, most likely a thyroglossal duct cyst. This mass was closely related to an angiomatous malformation involving the tongue, floor of mouth and left parotid. Fine needle aspiration cytology was consistent with a colloid goitre characterised as Thy-1. Due to her extensive comorbidities, surgical resection of the midline mass was deemed to be a high-risk procedure. A Sistrunk's procedure was performed. Dissection proved difficult due to the intimately related base of tongue haemangioma. Histopathology confirmed it to be a benign thyroglossal duct cyst. She made an uncomplicated postoperative recovery.

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Thyroglossal duct cyst carcinoma with concurrent thyroid carcinoma: a case report

Cited by 19 publications

References 12 publications

Papillary Carcinoma Thyroid in Thyroglossal Cyst- A Case Report

Papillary Carcinoma Thyroid in Thyroglossal Cyst- A Case Report

Papillary carcinoma in thyroglossal duct cyst: Diagnosis by fine‐needle aspiration cytology and immunocytochemistry

A rare case of a concurrent large thyroglossal duct cyst with a base of tongue haemangioma

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