Thyroglossal Duct Carcinoma

Pezzolla, Angela; Paradies, Daniele; Lattarulo, Serafina; Ciampolillo, Anna; Madami, Luigi

doi:10.1177/000313481508100118

Cited by 4 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By extension, however, the presence of a thyroid follicular based neoplasm, suggests thyroid gland tissue origin. Further, as carcinoma was only identified in four patients who also had a thyroidectomy [10,37,39,43] it seems to confirm a primary origin from ectopic thyroid gland tissue rather than representing metastatic disease. Other considerations would include a papillary thyroid carcinoma arising in the pyramidal lobe of the thyroid gland or metastatic carcinoma to the Delphian lymph node, but these considerations can be easily excluded by clinical and pathology findings.…”

Section: Discussionmentioning

confidence: 99%

“…In adults, TGDC associated malignancies are infrequently identified by FNA, primarily due to the inherently hypocellular nature of the specimen and failure to adequately sample the malignant component, which often comprises a small area of a predominantly cystic lesion [4,50,[73][74][75][76]. Among the reported pediatric patients with TGDC carcinoma, FNA was performed in five, and not performed in our patients [13,37,38,42,48]. One was interpreted as a thyroglossal duct cyst [13] three were atypical or suspicious for malignancy [37,38,42] and one was diagnosed as a papillary thyroid carcinoma [48].…”

Section: Discussionmentioning

confidence: 99%

“…Among the reported pediatric patients with TGDC carcinoma, FNA was performed in five, and not performed in our patients [13,37,38,42,48]. One was interpreted as a thyroglossal duct cyst [13] three were atypical or suspicious for malignancy [37,38,42] and one was diagnosed as a papillary thyroid carcinoma [48]. While potentially specific, given the limited number of patients upon whom a FNA was performed, no specific comment about its utility can be suggested in this age group.…”

Section: Discussionmentioning

confidence: 99%

“…This procedure results in an excellent long term outcome without any additional complications [3,4,77,78]. It would seem that with such a low chance of a concurrent primary thyroid gland tumor (all primary thyroid gland tumors were microscopic tumors and thus would not have been clinically detected [10,37,39,43]), the 6.6% chance of detecting an indolent or microscopic thyroid gland primary would make this procedure unnecessary. Conservative excision with clinical follow-up would be prudent, in an effort at de-escalation therapies for tumors which are quite indolent.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Thyroglossal Duct Cyst Carcinomas in Pediatric Patients: Report of Two Cases with a Comprehensive Literature Review

Thompson

Herrera

Lau³

2017

Head and Neck Pathol

View full text Add to dashboard Cite

Thyroglossal duct cyst (TGDC) carcinomas are rarely encountered in the pediatric population. The clinical behavior of these tumors in the pediatric setting is unclear and management is not well defined. Two cases of pediatric thyroglossal duct cyst carcinoma were identified in a review of all thyroglossal duct cysts diagnosed over a ten year period. These two cases were analyzed along with 57 cases of thyroglossal duct cyst carcinoma affecting patients less than 21 years of age compiled from the English literature. Fifty-nine patients (36 females, 23 males) aged 6-20 years (mean 15.0 years) were identified. All presented with an anterior midline neck mass, which was typically mobile and non-tender. The average tumor size was 2.6 cm. Histologically, all tumors were papillary thyroid carcinomas arising in a background of a thyroglossal duct cyst. The tumors exhibited a papillary, follicular, or mixed architecture with classical papillary thyroid carcinoma nuclear features. Soft tissue extension was present in 16 cases. All patients were managed surgically with a Sistrunk procedure, with additional thyroidectomy performed in 29 patients, combined with a lymph node dissection (n = 15), or a Sistrunk and lymph node dissection (n = 5). All patients were stage I at presentation, with 11 showing lymph node metastases. Postoperative radioactive iodine was employed in 20 patients. A papillary carcinoma of the thyroid gland was reported in four of the patients who had concurrent/subsequent thyroidectomies. Recurrences were reported in four patients, with distant metastases in one patient, who died of disease (13 months). Follow up data was available for 45 patients, with an overall mean follow-up of 54.5 months. All patients were alive, with the exception of one who died with disease. TGDC carcinomas in pediatric patients is associated with a good overall prognosis, best managed by Sistrunk procedure alone, with selected lymph node dissection if clinically indicated.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Thyroglossal Duct Cyst Carcinomas in Pediatric Patients: Report of Two Cases with a Comprehensive Literature Review

Thompson

Herrera

Lau³

2017

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…Out of all the cases that had total thyroidectomies, either as a concurrent or staged operation, only Pezzolla, et al (2015) reported positive findings of an incidental synchronous thyroid adenocarcinoma. Chrisoulidou, et al (2013) performed a total thyroidectomy subsequently as a result of TGDCa recurrence.…”

Section: Discussionmentioning

confidence: 99%

Thyroglossal Duct Cyst Carcinoma in The Pediatric Population: A Case Report and Literature Review

Yun¹,

Chen²,

Tien³

et al. 2022

FMCR

View full text Add to dashboard Cite

Thyroglossal duct cyst carcinoma (TGDCa) is a rare cause of neck masses in children. Its pathophysiology stems from two main theories. One suggests that the primary carcinoma originated from ectopic thyroid tissue, whilst the other suggest it is a result of metastasis to the thyroglossal duct cyst from the thyroid gland. A case of a 12-year-old girl who presented with a suspicious neck mass and subsequently diagnosed with TGDCa is reported. A literature review was performed and we conclude that aggressive surgical management of a Sistrunk procedure, total thyroidectomy, bilateral tracheoesophageal groove clearance and neck dissection was justified for this child. We found that if the preoperative diagnosis is TGDCa, a more aggressive surgical approach tends to be taken. However, cases of recurrence remain low and a total thyroidectomy does entail a larger morbidity for the pediatric patient. Hence, we do not recommend an aggressive approach routinely. In this review, we extrapolated AJCC data for thyroid malignancies and staged the TGDCa reported in literature in the last 10 years. It showed us that pT3 tumors tend to have a more aggressive surgical course, whilst a pT1 TGDCa tend to receive a more conservative surgical approach.

show abstract

Effectiveness of an advanced hemostatic pad combined with harmonic scalpel in thyroid surgery. A prospective study

Ruggiero

Docimo

Tolone

et al. 2016

International Journal of Surgery

View full text Add to dashboard Cite

show abstract

Thyroglossal Duct Carcinoma

Cited by 4 publications

References 2 publications

Thyroglossal Duct Cyst Carcinomas in Pediatric Patients: Report of Two Cases with a Comprehensive Literature Review

Thyroglossal Duct Cyst Carcinomas in Pediatric Patients: Report of Two Cases with a Comprehensive Literature Review

Thyroglossal Duct Cyst Carcinoma in The Pediatric Population: A Case Report and Literature Review

Effectiveness of an advanced hemostatic pad combined with harmonic scalpel in thyroid surgery. A prospective study

Contact Info

Product

Resources

About