Thyroglobulin Reference Values in a Pediatric Infant Population

Abstract

Few reports have addressed normal serum thyroglobulin (Tg) values in newborns and infants. In the present study, serum Tg was measured in 228 normal children (110 females and 118 males) aged from 3 to 180 days of life, all presenting normal age-related serum thyrotropin (thyroid-stimulating hormone [TSH]) values and negative anti-Tg and antithyroperoxidase antibodies. Serum Tg was measured by Radioimmunoassay (RIA) (two methods) and Immunometricassay (IMA) (three methods). Mean Tg values measured by the five methods exhibited among-method biases, although a significant positive correlation was observed. Serum Tg levels measured by the five methods showed a correlation with age, but not with TSH or gender. During the first days of life, relatively high mean Tg levels were observed, which progressively decreased until they reached a plateau. Therefore, with the aim of establishing reference values, the population was separated into two age groups: from 3 to 15 days of life (group A) and from 16 to 180 days of life (group B). Mean Tg concentration in group A was statistically higher than in group B. Tg centile distributions were calculated with the aim of establishing the normal levels of serum Tg for each method. We conclude that for a correct interpretation of serum Tg levels, the age and the methods used should be considered.

Screening of Parents and Siblings of Patients with Thyroid Dysgenesis by Thyroid Function Tests and Ultrasound

“…1 Pedigrees of cases with familial TD. Reference values: TSH 0.27–4.2 µIU/ml; T 4 5.1–14.1 µg/dl; fT 4 0.93–1.70 ng/dl; TG 6.44–82.8 ng/ml [16]. …”

Adrenal and thyroid function in the fetus and preterm infant

“…During gestation, there is a gradual increase in the levels of thyroid hormones. While thyroglobulin (TG) can be identified in the fetal thyroid gland as early as the 5th week, maturation of TG secretion takes much longer21,22). While iodide concentrating capacity can be detected in the thyroid of the 10- to 11-week fetus, the capacity of the fetal thyroid gland to reduce iodide trapping in response to excess iodide does not appear until 36- to 40-week gestation23).…”

Wrodzona niedoczynność tarczycy — polskie rekomendacje dotyczące leczenia, monitorowania terapii i badania przesiewowego w specjalnych kategoriach noworodków z wysokim ryzykiem niedoczynności tarczycy

“…Płód korzysta z T4 transportowanego do płynu owodniowego: stężenie T4 w płynie owodniowym jest około 10 razy wyższe niż we krwi płodu i prawie równe stężeniu T4 u matki [1][2][3][4][5][6]. Niedoczynność tarczycy u matki, zwłaszcza nieleczona przed 17. tygodniem ciąży, wpływa na pogorszenie rozwoju psychomotorycznego dziecka [7].…”

“…These maternal hormones exert an impact on brain development between gestation weeks 10 and 20. The foetus takes advantage of T4 transferred to the amniotic fluid: the level of T4 in the amniotic fluid is approximately tenfold higher than in the foetal blood and almost equal to that of the mother [1][2][3][4][5][6]. Maternal hypothyroidism, especially when untreated before gestation week 17, impairs the psychomotor development of the child [7].…”