Thyroglobulin as early prognostic marker to predict remission at 18–24 months in differentiated thyroid carcinoma

Abstract

Baseline-stimulated Tg is a good predictor of remission of disease at 18-24 months after initial treatment and could be a useful marker to stratify risk immediately after surgery.

Preablation Stimulated Thyroglobulin/TSH Ratio as a Predictor of Successful I131Remnant Ablation in Patients with Differentiated Thyroid Cancer following Total Thyroidectomy

“…Previous studies have focused on sTg only as a laboratory parameter for predicting the ablation outcome [16, 27]. A recent retrospective study conducted on 133 patients revealed that a preablation sTg < 8.55 ug/L predicted disease remission after 18–24 months of RRA with sensitivity of 88%, specificity of 72%, positive predictive value (PPV) of 47%, and negative predictive value (NPV) of 95% [18]. Another study conducted on 96 patients in Brazil found that patients with sTg levels < 18 ng/mL before RRA had 5.89 times greater chance of successful ablation compared to those with sTg > 18 ng/mL ( P < 0.0001) with sensitivity of 71.4%, specificity of 70.2%, PPV of 71.4%, and NPV of 70.2% [16].…”

“…However limitation of our study was its retrospective nature; therefore, we could retrieve data of only 75 patients who fulfilled our inclusion criteria. Many of the previous studies regarding role of sTg in predicting RRA outcome were also retrospective in nature [8, 15, 16, 18, 29, 31]. Another limitation of this study is use of different ablative doses in low, intermediate, and high risk groups which could have an impact on success of ablation as British Thyroid Association 2007 guidelines favor use of high dose for RRA [13].…”

“…sTg before RRA is a good predictor of successful ablation in these patients [15, 18]. Its levels can be influenced by tumor staging and TSH levels as well as other factors.…”

Multiple-factor analysis of the first radioactive iodine therapy in post-operative patients with differentiated thyroid cancer for achieving a disease-free status

“…For instance, pre-ablation stimulated Tg is known to be a good predictor of successful ablation in DTC patients 14 . Pre-ablation Tg has also been demonstrated as an important indicator for predicting persistence or recurrence during follow-up 15 16 17 . However, cut-off values of Tg for successful ablation or recurrence prediction were quite different among the above mentioned studies.…”

Clinical Outcomes and influence factors of differentiated thyroid carcinoma with negative preablative stimulated thyroglobulin and iodine-positive lymph nodes: A retrospective analysis

“…Analysis of the ROC showed that when 7.25 mm was used as the cut-off diameter of the lymph nodes for the prediction of poor prognosis, the Youden index was the highest (0.759), and the corresponding sensitivity and specificity were 93.3% and 82. [8][9][10]. Lee et al [11] have used 2 ng/ml as the cut-off ps-Tg level to predict the disease-free survival of DTC patients, and the NPV was as high as 94.9%.…”