Thymus dependency of cells involved in transfer of delayed hypersensitivity to listeria monocytogenes in mice

Youdim, S; Stuntman, Osias; Good, Robert A.

doi:10.1016/0008-8749(73)90129-9

Cited by 26 publications

(8 citation statements)

References 19 publications

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“…Many investigators have demonstrated that neutralizing ability in the Winn test is dependent on donor T-cells. Removal of these cells by any of several methods abolishes neutralization (Rollinghoff and Wagner, 1973;Rouse et al, 1973;Youdim et al, 1973;Gorczynski, 1974;McCoy et al, 1974). In addition, T-cells appear to be the only donor cell type required to participate in the neutralization reaction (Howell et al, 1974~).…”

Section: Discussionmentioning

confidence: 99%

Defects in cell‐mediated immunity during growth of a syngeneic simian virus‐induced tumor

Howell

Dean

Law

1975

Intl Journal of Cancer

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Four assays of tumor-specific cell-mediated immunity were compared during growth of a syngeneic Simian-virus-40-induced tumor, mKSA. Major differences were found in immunity detected by the tumor neutralization test (the Winn test), direct tumor challenge, the microcytotoxicity assay and the -51chromium-release lymphocytotoxicity assay. Progressive growth of the neoplasm followed by loss of immunity (the eclipse phenomenon) was documented with the Winn test. It was established that this eclipse phenomenon represented a lesion in the T-cell system of tumor-bearing hosts. This lesion was found to be specific and unrelated to anatomic tumor location. The ability to produce graft-versus-host reactions, and the ability to respond to mitogens, were found to be generally intact in tumor-bearing animals. Cells capable of recognizing mKSA tumor antigens and reconstituting an immune response following surgical removal of tumor or upon transfer to normal mice were found in the spleens of mice bearing advanced tumors. No suppressor cells that might account for the eclipse phenomenon could be demonstrated. Tumor-bearer serum did not block neutralizing activity of immune spleen cells in the Winn test, and immune cells were capable of neutralizing tumor even in tumor-bearing hosts. The possibility that the lesion is intrinsic to T-cell precursors of effector cells is discussed.

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Section: Discussionmentioning

confidence: 99%

Defects in cell‐mediated immunity during growth of a syngeneic simian virus‐induced tumor

Howell

Dean

Law

1975

Intl Journal of Cancer

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“…The role of the thymus in the expression of immunological competence and cell-mediated immunity has been the subject of numerous recent reviews and needs little further discussion here (79,175,189). However, it is interesting to note that, although DTH was early established as a T-cell-dependent reaction (12,266), it has only been in the last few years that this dependence has been extended to include cell-mediated immunity to intracellular parasites (150,188,242). The demonstration that adoptive transfer of immunity to Listeria challenge can be achieved with anti-theta sensitive lymphocytes (139) confirms the involvement of immunocompetent T-lymphocytes in the expression of antimicrobial immunity deduced from earlier studies using antilymphocyte serum (166) and the antimitotic drug vinblastine (244).…”

Section: T-lymphocytesmentioning

confidence: 99%

Vaccines and cell-mediated immunity.

Collins¹

1974

Bacteriological Reviews

209

144

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“…Confirmation that Listeria DTH is mediated by T ceils (27,28) is supplied in Fig. 2, where it can be seen that DTH failed to develop in Listeria-infected athymic nude mice.…”

Section: Resultsmentioning

confidence: 53%

Non-H-2 restriction of expression of passively transferred delayed sensitivity.

Berche¹,

North²

1982

The Journal of Experimental Medicine

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The results of this study of allogeneic restriction of passively transferred delayed sensitivity to Listeria antigens serve to illustrate the complexity of in vivo models. They show that the H-2 restriction observed when delayed-type hypersensitivity was transferred between H-2-congenic strains was no more severe than the restriction observed when delayed-type hypersensitivity was transferred between parental and F1 mice and between different strains sharing the same H-2 haplotype. It is obvious that genes, in addition to those of the H-2 locus, can be responsible for allogeneic restriction in vivo.

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Thymus dependency of cells involved in transfer of delayed hypersensitivity to listeria monocytogenes in mice

Cited by 26 publications

References 19 publications

Defects in cell‐mediated immunity during growth of a syngeneic simian virus‐induced tumor

Defects in cell‐mediated immunity during growth of a syngeneic simian virus‐induced tumor

Vaccines and cell-mediated immunity.

Non-H-2 restriction of expression of passively transferred delayed sensitivity.

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