Thymoquinone-Micellar Interactions: A physico-chemical investigation at molecular level

Nadeem, Iram; Yasmeen, Farhat; Sohail, Muhammad; Yaseen Khan, Athar; Nadeem Asghar, Muhammad

doi:10.1016/j.chemphys.2024.112198

Cited by 1 publication

(1 citation statement)

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“…Figures 1-3 show the UV-Vis spectra of the thymoquinone loading in different systems, i.e., the linear hydrogel, disulfide-crosslinked hydrogel, and genipin-crosslinked hydrogel, respectively. Supplementary Figure S1 depicts the absorption of the pure thymoquinone solution, and the peak occurs at 258 nm, which agrees well with Nadeem et al [17]. The absorption at this peak for a pure solution is 0.74, whereas Figure 1 shows the peak occurring at the same wavelength just after submersing the gel into the drug solution at zero hours at a reduced absorption of 0.63.…”

Section: Resultssupporting

confidence: 87%

Effect of Crosslinking Agents on Chitosan Hydrogel Carriers for Drug Loading and Release for Targeted Drug Delivery

Uddin,

Khand,

Dong

2024

Gels

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Numerous studies report on chitosan hydrogels in different forms, such as films, porous structures, nanoparticles, and microspheres, for biomedical applications; however, this study concentrates on their modifications with different crosslinking agents and observes their effects on drug loading and releasing capacities. Linear chitosan, along with chitosans crosslinked with two major crosslinkers, i.e., genipin and disulfide, are used to formulate three different hydrogel systems. The crosslinking process is heavily impacted by temperature and pH conditions. Three different drugs, i.e., thymoquinone, gefitinib, and erlotinib, are loaded to the hydrogels in de-ionized water solutions and released in phosphate-buffered solutions; thus, a total of nine combinations are studied and analyzed for their drug loading and releasing capabilities with ultraviolet–visible (UV–Vis) spectroscopy. This study finds that thymoquinone shows the lowest loading efficacy compared to the two other drugs in all three systems. Gefitinib shows stable loading and releasing regardless of crosslinking system, and the genipin-crosslinked system shows stable loading and releasing with all three drug molecules. These experimental results agree well with the findings of our previously published results conducted with molecular dynamics simulations.

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Section: Resultssupporting

confidence: 87%