Thymoquinone Induces Apoptosis in Oral Cancer Cells Through P38β Inhibition

Abdelfadil, Ehab; Cheng, Yi‐Chiao; Bau, Da Tian; Wei, Ting; Chen, Li Mien; Hsu, Hsi Hsien; Lin, Yueh Min; Chen, Ray Jade; Tsai, Fu Jenn; Tsai, Chang Hai; Huang, Chih Yang

doi:10.1142/s0192415x1350047x

Cited by 56 publications

(45 citation statements)

References 61 publications

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“…The anti-tumor activity of thymoquinone in oral cancer might be attributed to the down-regulation of p38β MAPK [115]. Besides, in head and neck squamous cell carcinoma, thymoquinone induced apoptosis involving an increase in Bax expression and caspase-9 activation, and induced autophagy which depended on increasing levels of autophagic vacuoles and LC3-II proteins, the specific autophagy markers [116].…”

Section: Nigella Sativa and Thymoquinonementioning

confidence: 99%

Spices for Prevention and Treatment of Cancers

et al. 2016

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Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin. The main mechanisms of action include inducing apoptosis, inhibiting proliferation, migration and invasion of tumors, and sensitizing tumors to radiotherapy and chemotherapy. This review summarized recent studies on some spices for prevention and treatment of cancers, and special attention was paid to bioactive components and mechanisms of action.

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Section: Nigella Sativa and Thymoquinonementioning

confidence: 99%

Spices for Prevention and Treatment of Cancers

et al. 2016

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“…Lang and collaborators [97] showed that thymoquinone interfered with polyp progression in ApcMin mice through induction of tumor-cell specific apoptosis and modulation of Wnt signaling through activation of GSK-3 β . Thymoquinone also induced apoptosis in oral cancer cells through P38 β inhibition [98]. Odeh and collaborators [99] described the encapsulation of thymoquinone into a liposome, which maintained stability and improved bioavailability, while it maintained anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Monoterpenes Found in Essential Oils

Sobral

Xavier

Lima

et al. 2014

The Scientific World Journal

213

142

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Cancer is a complex genetic disease that is a major public health problem worldwide, accounting for about 7 million deaths each year. Many anticancer drugs currently used clinically have been isolated from plant species or are based on such substances. Accumulating data has revealed anticancer activity in plant-derived monoterpenes. In this review the antitumor activity of 37 monoterpenes found in essential oils is discussed. Chemical structures, experimental models, and mechanisms of action for bioactive substances are presented.

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“…Primary oral cancer cells T8, T28, and non‐tumor cell N28 used in this study was kindly provided by Dr. Da‐Tian Bau, Department of Medical Research, China Medical University Hospital, Taiwan. Cell lines representing chemically induced oral squamous cell carcinoma (T8, T28) in C57BL/6J Narl mice, as well as non‐tumor cells (N28) obtained from tissues surrounding the induced cancer (Abdelfadil et al, ). Arecoline in combination with 4‐NQO was used in the drinking water of the mice to induce cancer.…”

Section: Methodsmentioning

confidence: 99%

Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice

et al. 2015

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Helioxanthin, an active compound from Taiwania cryptomerioides Hayata, has been shown to have various biological activities. However, their anticancer effect in oral squamous cell carcinoma has not been well established yet. Helioxanthin inhibited the proliferation of oral squamous cell carcinoma cells in a dose-dependent manner by inducing G2/M phase arrest. Similarly, helioxanthin inhibited cyclooxygenase-2, (COX-2), phosphorylated EGFR, and extracellular-signal-regulated kinases (ERK) protein level and further reduced the nuclear accumulation of phosphorylated epidermal growth factor receptor (pEGFR) and activator protein-1(AP-1) family protein, c-fos. Moreover, helioxanthin at the dose of 20 and 30 mg kg for 15 days reduced the tumor growth in animal model. This study demonstrated that Helioxanthin exerts its anticancer activity against oral cancer cells by downregulating EGFR/ERK/c-fos signaling pathway to inhibit COX-2 level and by activating cyclin-dependent kinase inhibitor (p27) to further induce G2/M cell cycle arrest. This helioxanthin may serve as a novel candidate for oral cancer prevention. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 2045-2056, 2016.

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Thymoquinone Induces Apoptosis in Oral Cancer Cells Through P38β Inhibition

Cited by 56 publications

References 61 publications

Spices for Prevention and Treatment of Cancers

Spices for Prevention and Treatment of Cancers

Antitumor Activity of Monoterpenes Found in Essential Oils

Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice

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