Thymoquinone-induced relaxation of isolated rat pulmonary artery

Suddеk, Ghada M.

doi:10.1016/j.jep.2009.11.019

Cited by 23 publications

(24 citation statements)

References 19 publications

(20 reference statements)

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“…103,104 Indeed, TQ prevented N-nitro-L-arginine methyl esterinduced hypertension and renal damage in rats possibly via its antioxidant activity 105 and induced relaxations of phenylephrine-contracted rat pulmonary artery rings. 106 A recent study showed that TQ improves aging-related endothelial dysfunction in the rat mesenteric artery. 107 The study was carried out on 12 middle-aged (46 weeks) male Wistar rats divided into 2 groups of 6 rats receiving either solvent (3% ethanol vol/vol) or TQ (10 mg/kg per day) in the drinking water for 14 days.…”

Section: Concord Grapesmentioning

confidence: 99%

Effects of Selected Bioactive Natural Products on the Vascular Endothelium

Ahmad¹,

Khan²,

Alkharfy

2013

Journal of Cardiovascular Pharmacology

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The endothelium, a highly active structure, regulates vascular homeostasis through the release of numerous vasoactive factors that control vascular tone and vascular smooth cell proliferation. A larger number of medicinal plants and their isolated chemical constituents have been shown to beneficially affect the endothelium. For example, flavonoids in black tea, green tea, and concord grape cause a vasodilation possibly through their antioxidant properties. Allicin, a by-product of the enzyme alliinase, has been proposed to be the main active metabolite and responsible for most of the biological activities of garlic, including a dose-dependent dilation on the isolated coronaries. Thymoquinone, the principal phytochemical compound found in the volatile oil of the black seed, and the hawthorn extract have also been shown to improve aging-related impairment of endothelium-dependent relaxations in animal models. In this review, the effect of some of the natural products, including Camellia sinensis (black tea and green tea), Vitis labrusca (concord grape), Allium sativum (garlic), and Nigella sativa (black seed) and Crataegus ssp (hawthorn extract), is explored. The molecular mechanisms behind these potential therapeutic effects are also discussed.

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Section: Concord Grapesmentioning

confidence: 99%

Effects of Selected Bioactive Natural Products on the Vascular Endothelium

Ahmad¹,

Khan²,

Alkharfy

2013

Journal of Cardiovascular Pharmacology

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“…It has been reported that resveratrol also can modulate age-and diseaseinduced reduction of vascular stiffening by inhibiting inflammation-related growth factor signaling pathway (Khurana et al 2013). Thymoquinone, a constituent of the volatile oil of black cumin seeds, has potent anti-oxidative effects (Tesarova et al 2011) and vasorelaxation effects (Suddek 2010). Furthermore, thymoquinone attenuated vascular oxidative stress and improved the endothelial dysfunction related to aging in Wistar rats (Idris-Khodja and SchiniKerth 2012).…”

Section: Discussionmentioning

confidence: 99%

Augmentation of ferulic acid-induced vasorelaxation with aging and its structure importance in thoracic aorta of spontaneously hypertensive rats

Fukuda

Kuroda

Kono

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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Aging deteriorates vascular functions such as vascular reactivity and stiffness. Thus far, various reports suggest that bioactive compounds can improve vascular functions. However, few age-related studies of natural bioactive compounds are available. The present study attempted to evaluate age-related vasorelaxation of bioactive cinnamic acids, caffeic acid, and ferulic acid using aged rat thoracic aorta. Vasorelaxation was evaluated in thoracic aorta from both 8, 18, and 40 weeks old Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) respectively. The result indicated that caffeic acid possessed the vasorelaxation regardless of aging in WKY and SHR. Moreover, the vasorelaxation of ferulic acid enhanced with aging in SHR. The vasorelaxation behavior was acted in an endothelium-independent manner. To access structure importance of enhanced vasorelaxation, analogues of ferulic acid were tested. In 40 weeks old SHR, 3,4-dimethoxycinnamic acid and coniferyl alcohol exhibited equivalent vasorelaxation activity with ferulic acid, providing the structural importance of methoxy-modified 3-position on the phenyl ring and 2-propenoic moiety. These results firstly demonstrated that enhanced vasorelaxation of ferulic acid with aging and 3,4-dimethoxycinnamic acid and coniferyl alcohol, along with ferulic acid, might exhibit the therapeutic potential of vasoactive power with aging.

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“…TQ has well-documented antioxidative properties and vasodilator effect (Butt and Sultan 2010;Tesarova et al 2011;Suddek 2010). Indeed, TQ prevented L-NAME-induced hypertension and renal damage in rats possibly via its antioxidant activity (Khattab and Nagi 2007) and induced relaxations of phenylephrine-contracted rat pulmonary artery rings (Suddek 2010). On the basis of the above, we hypothesized that TQ may attenuate oxidative stress in middle-aged rat arteries and, hence, improve the endothelial dysfunction related to aging.…”

Section: Introductionmentioning

confidence: 91%

“…Thymoquinone (TQ) is the most active constituent of the volatile oil of Nigella sativa seeds, which has shown potential medicinal properties and has long been used in traditional and folk medicines (Ragheb et al 2009). TQ has well-documented antioxidative properties and vasodilator effect (Butt and Sultan 2010;Tesarova et al 2011;Suddek 2010). Indeed, TQ prevented L-NAME-induced hypertension and renal damage in rats possibly via its antioxidant activity (Khattab and Nagi 2007) and induced relaxations of phenylephrine-contracted rat pulmonary artery rings (Suddek 2010).…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery

Idris‐Khodja

Schini‐Kerth

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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Aging-related endothelial dysfunction is characterized by blunted nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxations in arteries, which may be due, at least in part, to increased oxidative stress. Endothelial dysfunction will promote the initiation and development of major cardiovascular diseases such as atherosclerosis and hypertension. Thymoquinone (TQ) is the most active constituent of the volatile oil of Nigella sativa seeds with well-documented antioxidative properties and vasodilator effects. This study determined whether TQ improves the endothelial function in middle-aged rats. Control young rats (16 weeks) received solvent (ethanol, 3% v/v), and middle-aged rats (46 weeks) either solvent or TQ (10 mg/kg/day) in the drinking water. Mesenteric artery reactivity was determined in organ chambers, vascular oxidative stress by dihydroethidine and MitoSOX staining, and expression of target proteins by immunohistochemical staining. Aging-related blunted NO- and EDHF-mediated responses were associated with downregulation of endothelial NO synthase (eNOS) and calcium-activated potassium channels (SK(Ca) and IK(Ca)) expression. Endothelial dysfunction was also associated with oxidative stress and an upregulation of angiotensin II and AT1 receptor expressions. Intake of TQ for 14 days restored NO- and EDHF-mediated relaxations, normalized oxidative stress, the expression level of eNOS, SK(Ca), IK(Ca), and the components of the angiotensin system in the mesenteric artery of middle-aged rats. Thus, TQ improves endothelial function in aging, at least in part, through inhibition of oxidative stress and normalization of the angiotensin system. TQ may represent a novel therapeutic approach for aging-associated vascular diseases.

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Thymoquinone-induced relaxation of isolated rat pulmonary artery

Cited by 23 publications

References 19 publications

Effects of Selected Bioactive Natural Products on the Vascular Endothelium

Effects of Selected Bioactive Natural Products on the Vascular Endothelium

Augmentation of ferulic acid-induced vasorelaxation with aging and its structure importance in thoracic aorta of spontaneously hypertensive rats

Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery

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