Thymoquinone and quercetin protect against hepatic steatosis in association with SIRT1/AMPK stimulation and regulation of autophagy, perilipin-2, and cytosolic lipases

Ashour, Hend; Rashed, Laila Ahmed; Hassanein, Radwa Taha; Aboulhoda, Basma Emad; Ebrahim, Hasnaa Ali; Elsayed, Mohamed H; Elkordy, Miran Atif; Abdelwahed, Omaima Mohammed

doi:10.1080/13813455.2022.2134423

Cited by 3 publications

(1 citation statement)

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“…In contrast, the NADPH required for fatty acid synthesis in the liver of birds is supplied mainly through the pyruvate-malate pathway, comprising NADP-ME ( 44 ). As the major metabolite of rutin, quercetin can increase the potential of anti-steatosis in the liver of rat by reducing the activity of hepatic lipogenic enzymes and activating the cytoplasmic lipase adipose triglyceride lipase (ATGL) activity ( 45 ). Administration of rutin in adipocytes inhibits the activity of alpha-glucosidase and pancreatic lipase and increases adiponectin levels in vitro ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Positive effects of rutin on egg quality, lipid peroxidation and metabolism in post-peak laying hens

Zhang,

Gong,

et al. 2024

Front. Vet. Sci.

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Excessive fat deposition due to impaired fat metabolism in chickens is a major problem in the poultry industry. Nutritional interventions are effective solutions, but current options are limited. A safe phytochemical, rutin, has shown positive effects in animals, but its effect on lipid metabolism in poultry remains unknown. Hence, this study is to investigate the effects of rutin on egg quality, serum biochemistry, fat deposition, lipid peroxidation and hepatic lipid metabolism in post-peak laying hens. A total of 360 Taihang laying hens (49-week-old) were randomly divided into five groups and fed a basal diet (control group, 0%) and a basal diet supplemented with 300 (0.03%), 600 (0.06%), 900 (0.09%), and 1,200 (0.12%) mg rutin/kg feed, respectively. The results showed that eggshell strength was significantly (p < 0.05) higher in the dietary rutin groups, whereas yolk percentage (p < 0.05), total cholesterol (TC) (p < 0.01) and yolk fat ratio (p < 0.01) decreased linearly (p < 0.05) in the dietary rutin groups. Importantly, dietary rutin reduced serum triglyceride (TG) and TC levels, decreased abdominal lipid deposition and liver index (p < 0.05), and which concomitantly decreased hepatic lipid (TG, TC, and free fatty acid) accumulation (p < 0.05). An increase (p < 0.05) in total antioxidant capacity and superoxide dismutase activity and a decrease (p < 0.05) in malondialdehyde levels were also found. At the same time, the activities of hepatic lipase, acetyl-CoA carboxylase and malic enzyme in the liver were decreased (p < 0.05). Dietary rutin also increased (p < 0.05) the expression of fatty acid oxidation-related genes (carnitine palmitoyl transferase 1, peroxisome proliferator-activated receptor α, farnesoid X receptor). Additionally, it decreased fatty acid synthesis genes (sterol regulatory element binding protein-1c, acetyl-CoA carboxylase α, stearoyl-CoA desaturase 1) (p < 0.05). In conclusion, the addition of rutin (0.06–0.12%) to the diet improved the fat metabolism and increased liver antioxidant capacity in post-peak laying hens, and these positive changes improved egg quality to some extent.

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Section: Discussionmentioning

confidence: 99%