Thymoquinone Ameliorates Renal Oxidative Damage and Proliferative Response Induced by Mercuric Chloride in Rats

Fouda, Abdel-Motaal; Daba, Mohamad-Hesham Y.; Dahab, Gamal M.; el-Din, Osama A. Sharaf

doi:10.1111/j.1742-7843.2008.00260.x

Cited by 73 publications

(50 citation statements)

References 43 publications

(66 reference statements)

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“…In different toxicity studies it was found that the administration of TQ led to decreased MDA levels [30,33,34,35]. In the present study, TQ protected prostate tissue from NO- and MDA-dependent oxidative stress when administered at 24, 48, and 72 h (p < 0.05; fig.…”

Section: Discussionsupporting

confidence: 56%

Antioxidative and Anti-inflammatory Effect of Thymoquinone in an Acute Pseudomonas Prostatitis Rat Model

Rifaioğlu¹,

Nacar²,

Yuksel³

et al. 2013

Urol Int

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Introduction: The aim of this study is to investigate the potential antioxidant and anti-inflammatory effects of thymoquinone (TQ) to improve acute bacterial prostatitis (ABP) induced by Pseudomonas aeruginosa. Material and Methods: A total of 42 male Wistar albino rats were divided into 7 groups as follows: control, ABP (24, 48, and 72 h), and TQ-ABP (24, 48, and 72 h). The prostate tissue samples were assayed for prostate tissue malondialdehyde (MDA) and nitric oxide(NO) levels, and catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities. Sections were examined for characteristic histological changes, and a histological scoring system was used. Results: When the ABP groups given TQ (24, 48, and 72 h) were compared to the ABP groups not given TQ, the levels of MDA and NO and the GPX activity were found to be significantly lower in the groups given TQ. Concerning SOD values, the TQ-ABP-72 group was lower in comparison with the ABP-72 and control groups, but statistically higher than the TQ-ABP-48 group (p < 0.05). Concerning CAT activity, only the TQ-ABP-72 and ABP-72 groups had a significant difference with the control group. TQ improved prostate histology significantly only in the TQ-ABP-24 group compared to the ABP-24 group (p < 0.001). Conclusion: Our study demonstrated for the first time that ABP induced by P. aeruginosa had an oxidative effect on prostate tissue and could regress following TQ administrationas shown withthe biochemical and histological findings.

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Section: Discussionsupporting

confidence: 56%

Antioxidative and Anti-inflammatory Effect of Thymoquinone in an Acute Pseudomonas Prostatitis Rat Model

Rifaioğlu¹,

Nacar²,

Yuksel³

et al. 2013

Urol Int

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“…Fouda et al [70] investigated protective effects of TQ in mercuric chloride (HgCl 2 )-induced nephrotoxicity. Their results showed that the deterioration of antioxidant enzymes, increase in serum Cr and histological injury induced by HgCl 2 were markedly ameliorated by TQ therapy (10 mg/kg/day).…”

Section: Resultsmentioning

confidence: 99%

An Overview on Renoprotective Effects of Thymoquinone

et al. 2018

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Background: Kidneys as vital organs remove waste material from blood. Additionally, they may also have a role in the electrolyte balance, regulation of blood pressure, and red blood cell genesis. Kidney diseases may be caused by several factors such as ischemia/reperfusion injury, diabetes, and nephrotoxic agents. Oxidative stress and inflammation are involved in the pathogenesis and progression of kidney diseases. Traditionally, natural antioxidants are used for treatment of renal failure in various countries. Summary: People usually select natural antioxidants since they have an opinion that herbal medicine has not any important side effects. Nigella sativa is a flavoring herb that is widely used as a condiment and as a remedy for many disorders. Thymoquinone (TQ), the most important component of black seeds, mainly oil, is considered as an active agent responsible for a lot of the seed’s useful effects. This review describes the protective roles and related mechanisms of TQ against renal disorders. The search terms, including TQ, antioxidant, renal ischemia-reperfusion, diabetic nephropathy, and nephrotoxic agent were searched in scientific databases. TQ showed anti-inflammatory and antioxidant properties in animal and in vitro models of several renal diseases caused by inflammation and oxidative stress. Key Messages: Experimental studies have shown beneficial effects of TQ against renal diseases; however, well-designed clinical trials in humans are required to confirm these effects.

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“…TQ (2-isopropyl-5-methyl-1,4-benzoquinone), the main active component of the essential oil of Nigella sativa seeds, has various pharmacological effects. It has been reported to display various pharmacological activities such as antioxidant (7), antidiabetic (8), cardioprotective (9), hepatoprotective (10), neuroprotective (11), nephroprotective (12), anti-infl ammatory (13), anti-mutagenic (14), and anticancer (15) effects. TQ is of low toxicity (LD50 2.4 g/kg) and is well tolerated when given subchronically till 90 mg/ kg/day for 90 days (16).…”

Section: Introductionmentioning

confidence: 99%

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

Bilğiç¹,

Korkmaz²,

Azırak³

et al. 2018

BLL

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OBJECTIVES: The aim of the study was to investigate the possible protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat liver with histologic and biochemical assessments. METHODS: Experimental procedures were performed on 35 female Sprague Dawley rats. Rats were randomly divided into fi ve groups as: group 1: control; group 2: OLZ; group 3: OLZ+TQ-1; group 4: OLZ+TQ-2; and group 5: OLZ+TQ-3. RESULTS: The results showed that a 2-week administration of OLZ (4 mg/kg, once a day for the fi rst week, 8 mg/kg once a day for the second week, p.o.) and treatment with TQ (25, 50, 100 mg/kg, once daily, p.o.) signifi cantly reduced weight gain induced by OLZ. In addition, TQ increased the total antioxidant status (TAS), high-density lipoprotein cholesterol (HDL), insulin levels and decreased serum oxidative stress index (OSI), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), low density lipoprotein cholesterol (LDL), glucose, triglycerides (TG) and total cholesterol (CH) levels signifi cantly (p < 0.05). CONCLUSION: This study revealed that treatment with TQ might protect liver tissue against the side-effects of OLZ. TQ could be an effective course of therapy to enhance therapeutic effi cacy (Tab. 4, Fig. 4, Ref. 47). Text in PDF www.elis.sk.

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Thymoquinone Ameliorates Renal Oxidative Damage and Proliferative Response Induced by Mercuric Chloride in Rats

Cited by 73 publications

References 43 publications

Antioxidative and Anti-inflammatory Effect of Thymoquinone in an Acute <b><i>Pseudomonas</i></b> Prostatitis Rat Model

Antioxidative and Anti-inflammatory Effect of Thymoquinone in an Acute <b><i>Pseudomonas</i></b> Prostatitis Rat Model

An Overview on Renoprotective Effects of Thymoquinone

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

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