Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1–42 infused rat model

Elibol, Birsen; Beker, Merve; Terzioglu-Usak, Sule; Dalli, Tugce; Kılıç, Ülkan

doi:10.1016/j.phymed.2020.153324

Cited by 23 publications

(17 citation statements)

References 37 publications

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“…The protective effect and therapeutic values of thymoquinone have been documented for various conditions such as asthma ( Ammar el et al, 2011 ; Kalemci et al, 2013 ; Keyhanmanesh et al, 2014 ), wound healing ( Selçuk et al, 2013 ; Siriwattanasatorn et al, 2020 ), liver damage ( Zeinvand-Lorestani et al, 2018 ; Atteya et al, 2019 ), diabetes ( El-Shemi et al, 2018 ; Rani et al, 2018 ), degenerative diseases ( Angeles et al, 2016 ; Ebrahimi et al, 2017 ; Elibol et al, 2020 ), and inflammation-related diseases ( Pop et al, 2020 ). Thymoquinone has been recognized to exert anti-inflammatory and antioxidant properties ( Parlar and Arslan, 2020 ; Savran et al, 2020 ).…”

Section: Pharmacological Properties Of Thymoquinonementioning

confidence: 99%

Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways

Mahmud

Paraoan

Khaliddin

et al. 2022

Front. Cell. Neurosci.

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Thymoquinone is a naturally occurring compound and is the major component of Nigella sativa, also known as black seed or black cumin. For centuries thymoquinone has been used especially in the Middle East traditionally to treat wounds, asthma, allergies, fever, headache, cough, hypertension, and diabetes. Studies have suggested beneficial effects of thymoquinone to be attributed to its antioxidant, antibacterial, anti-oxidative stress, anti-inflammatory, and neuroprotective properties. Recently, there has been a surge of interest in thymoquinone as a treatment for neurodegeneration in the brain, such as that seen in Alzheimer’s (AD) and Parkinson’s diseases (PD). In vitro and in vivo studies on animal models of AD and PD suggest the main neuroprotective mechanisms are based on the anti-inflammatory and anti-oxidative properties of thymoquinone. Neurodegenerative conditions of the eye, such as Age-related Macular Degeneration (AMD) and glaucoma share at least in part similar mechanisms of neuronal cell death with those occurring in AD and PD. This review aims to summarize and critically analyze the evidence to date of the effects and potential neuroprotective actions of thymoquinone in the eye and ocular neurodegenerations.

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Section: Pharmacological Properties Of Thymoquinonementioning

confidence: 99%

Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways

Mahmud

Paraoan

Khaliddin

et al. 2022

Front. Cell. Neurosci.

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“…As previously said, AD is linked to protein (i.e., Aβ) aggregation which may, in turn, induce oxidative stress leading to neuro-inflammation. Yusuf et al designed PLGA NPs loaded with thymoquinone (TQ), a phytochemical compound, to act on this aspect in animal models due to its potent antioxidant and anti-inflammatory properties ( Figure 3 ) [ 53 , 54 ]. Male albino mice administered with Streptozotocin (SZT) (mimicking AD oxidative stress by a decrease of SOD activity) were treated with TQ loaded PLGA NPs, coated with polysorbate 80 (P-80-TQN).…”

Section: Plga Nps For Neuroprotective Drug Delivery In Neurological Disorder Therapymentioning

confidence: 99%

PLGA-Based Nanoparticles for Neuroprotective Drug Delivery in Neurodegenerative Diseases

et al. 2021

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Treatment of neurodegenerative diseases has become one of the most challenging topics of the last decades due to their prevalence and increasing societal cost. The crucial point of the non-invasive therapeutic strategy for neurological disorder treatment relies on the drugs’ passage through the blood-brain barrier (BBB). Indeed, this biological barrier is involved in cerebral vascular homeostasis by its tight junctions, for example. One way to overcome this limit and deliver neuroprotective substances in the brain relies on nanotechnology-based approaches. Poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) are biocompatible, non-toxic, and provide many benefits, including improved drug solubility, protection against enzymatic digestion, increased targeting efficiency, and enhanced cellular internalization. This review will present an overview of the latest findings and advances in the PLGA NP-based approach for neuroprotective drug delivery in the case of neurodegenerative disease treatment (i.e., Alzheimer’s, Parkinson’s, Huntington’s diseases, Amyotrophic Lateral, and Multiple Sclerosis).

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“…Number of article Route of Administration ICV IP Oral Sub-cutaneous Amyloid β** 35 [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34]. [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47] 35 0 0 0 Streptozotocin** 16 [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63] 16...…”

Section: Toxic Substancesmentioning

confidence: 99%

“…Therefore, the study is less appealing for many researchers with limited resources. Studies on sex differences in AD rat models are limited to five studies, that is, two articles using Aβ [33], [45], one study using STZ [61], one study used HSCD [90], and one study used letrozole [91]. Those limited studies reported that female rats are comparable to male rats on MWM, AD markers, and neurodegenerative markers upon toxic induction.…”

Section: Biomarkersmentioning

confidence: 99%

“…Those limited studies reported that female rats are comparable to male rats on MWM, AD markers, and neurodegenerative markers upon toxic induction. Nevertheless, further study on female animal models should be encouraged, because the number of women who suffer from AD is actually more than men with AD [33] and sexual differences in animal models of other brain-related diseases have been reported [105]. Differential hormonal secretion and sex chromosome gene expression may induce different pathogenesis, markers, and therapeutic efficacy in women [106].…”

Section: Biomarkersmentioning

confidence: 99%

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Toxic Substance-induced Hippocampal Neurodegeneration in Rodents as Model of Alzheimer’s Dementia

Nurmasitoh

Sari

Susilowati

2021

Open Access Maced J Med Sci

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BACKGROUND: Alzheimer’s Dementia (AD) cases are increasing with the global elderly population. To study the part of the brain affected by AD, animal models for hippocampal degeneration are still necessary to better understand AD pathogenesis and develop treatment and prevention measures. AIM: This study was a systematic review of toxic substance-induced animal models of AD using the Morris Water Maze method in determining hippocampal-related memory impairment. Our aim was reviewing the methods of AD induction using toxic substances in laboratory rodents and evaluating the report of the AD biomarkers reported in the models. METHODS: Data were obtained from articles in the PubMed database, then compiled, categorized, and analyzed. Eighty studies published in the past 5 years were included for analysis. RESULTS AND DISCUSSION: The most widely used method was intracerebroventricular injection of amyloid-β _substances. However, some less technically challenging techniques using oral or intraperitoneal administration of other toxic substances also produce successful models. Instead of hippocampal neurodegeneration, many studies detected biomarkers of the AD pathological process while some reported inflammation, oxidative stress, neurotrophic factors, and changes of cholinergic activity. Female animals were underrepresented despite a high incidence of AD in women. CONCLUSION: Toxic substances may be used to develop AD animal models characterized with appropriate AD pathological markers. Characterization of methods with the most easy-handling techniques and more studies in female animal models should be encouraged.

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Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1–42 infused rat model

Cited by 23 publications

References 37 publications

Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways

Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways

PLGA-Based Nanoparticles for Neuroprotective Drug Delivery in Neurodegenerative Diseases

Toxic Substance-induced Hippocampal Neurodegeneration in Rodents as Model of Alzheimer’s Dementia

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