Thymoquinone

Gupta, Bhanushree; Ghosh, Kallol K.; Gupta, Ramesh C.

doi:10.1016/b978-0-12-802147-7.00039-5

Cited by 18 publications

(13 citation statements)

References 86 publications

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“…It has promising pharmacological properties in the treatment of a variety of diseases. It had potent antioxidant, anti-inflammatory, anti-cancer, and other biologically significant properties (Gupta, 2016). Almost no side effects were observed irrespective of a large dose range, indicating a broad therapeutic window (Tekbas et al, 2018).…”

Section: Radioprotective Effect Of Thymoquinone In X-irradiated Ratsmentioning

confidence: 99%

Radioprotective Effect of Thymoquinone in X-irradiated Rats

El-Benhawy

Morsi

El-Tahan

et al. 2021

Asian Pac J Cancer Prev

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Background: Thymoquinone, has anti-inflammatory, anti-oxidant, and cardio protection properties. This study aimed to evaluate the radioprotective effect of thymoquinone in whole body X-irradiated rats. Methods: This study conducted on 40 male adult Wistar albino rats randomized into the following groups: Group I: Control rats did not receive thymoquinone or ionizing radiation. Group II: Whole-body irradiated rats with 6 Gy of X-ray. Group III: Rats orally intubated with thymoquinone (10 mg/kg/day) for 7 days then subjected to whole-body irradiation with 6 Gy then supplemented with thymoquinone for another 7 days. Group IV: Rats orally intubated with thymoquinone (20 mg/kg/day) for 7 days then subjected to whole-body irradiation with 6 Gy then supplemented with thymoquinone (20 mg/kg/day) for another 7 days. LDH, CK-MB, ALT, AST, MDA, TAC, Catalase activity, GPX, GSR and GSH were measured. Results: Lipid peroxidation biomarker in the blood of X-irradiated rats significantly increased and accompanied by decrease in the levels of GSH, GSR, GPX, catalase as well as TAC. Moreover, exposure to IR significantly increases cardiac and liver enzymes. However, administration of TQ to X-irradiated rats with either 10 mg/kg or 20 mg/kg have the same reform effects and significantly protects rats against adverse effects of IR. Conclusion: Exposure to X-ray leads to significant changes in cellular biochemical and morphological conditions. Administration of TQ before radiation treatment significantly decreases the adverse effects of IR. TQ can improve cardiac function, decrease myocardial enzyme levels and inhibit oxidative stress.

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Section: Radioprotective Effect Of Thymoquinone In X-irradiated Ratsmentioning

confidence: 99%

Radioprotective Effect of Thymoquinone in X-irradiated Rats

El-Benhawy

Morsi

El-Tahan

et al. 2021

Asian Pac J Cancer Prev

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“…Gymnostigmaeus akaminei Ehara & Ueckermann, 2006: 31;Fan et al, 2016: 89 Type locality: Okinawa Distribution: Japan Genus Indostigmaeus Gupta et Ghosh Indostigmaeus Gupta & Ghosh, 1980: 204 Type species: Indostigmaeus rangatensis Gupta et Ghosh, 1980 Indostigmaeus makilingae (Rimando et Corpuz-Raros) Mullederia makilingae…”

Section: Gymnostigmaeus Akaminei Ehara Et Ueckermannmentioning

confidence: 99%

Acarorum Catalogus Vii

Beron¹

2020

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“…Continuous positive airway pressure (CPAP) keeps airways open by administering positive pressure to the airways of spontaneously breathing patients throughout the respiratory cycle (Gupta 2016). Continuous positive airway pressure may be given to infants using nasal prongs, nasopharyngeal tube, or an infant nasal mask.…”

Section: Description Of the Interventionmentioning

confidence: 99%

“…Continuous positive airway pressure devices may include provision of heated and humidified airflow. Continuous positive airway pressure use has been associated with adverse e ects, including local and systemic e ects, such as nasal mucosal damage, nasal excoriation, scarring, pressure necrosis, and nasal septum distortion (Gupta 2016;Lee 2002;Robertson 1996), aspiration secondary to gastric insu lation (Kiciman 1998), pneumothorax (de Bie 2002, and decreased cardiac output due to impaired pulmonary blood flow (Lee 2002).…”

Section: Description Of the Interventionmentioning

confidence: 99%

Continuous positive airway pressure (CPAP) for acute bronchiolitis in children

Jat

Mathew

2019

Cochrane Database of Systematic Reviews

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BackgroundAcute bronchiolitis is one of the most frequent causes of emergency department visits and hospitalisation in children. There is no specific treatment for bronchiolitis except for supportive treatment, which includes ensuring adequate hydration and oxygen supplementation. Continuous positive airway pressure (CPAP) aims to widen the lungs' peripheral airways, enabling deflation of overdistended lungs in bronchiolitis. Increased airway pressure also prevents the collapse of poorly supported peripheral small airways during expiration. Observational studies report that CPAP is beneficial for children with acute bronchiolitis. This is an update of a review first published in 2015. ObjectivesTo assess the e icacy and safety of CPAP compared to no CPAP or sham CPAP in infants and children up to three years of age with acute bronchiolitis.

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Thymoquinone

Cited by 18 publications

References 86 publications

Radioprotective Effect of Thymoquinone in X-irradiated Rats

Radioprotective Effect of Thymoquinone in X-irradiated Rats

Acarorum Catalogus Vii

Continuous positive airway pressure (CPAP) for acute bronchiolitis in children

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