Thymoma: Results of 241 operated cases

Maggi, G; Casadio, Caterina; Ardissone, Francesco; Mancuso, Maurizio; Oliaro, A; Pischedda, F; Cavallo, A; Cianci, R; Giobbe, Roberto; Molinatti, M

doi:10.1016/0003-4975(91)90478-9

Cited by 329 publications

(267 citation statements)

References 15 publications

Supporting

Mentioning

213

Contrasting

Unclassified

Order By: Relevance

“…Similar results have been observed in prior studies, in which the better survival in patients with myasthenia had been attributed to earlier diagnosis. 27,51 However, the use of this factor in prognostication has been controversial as some studies have not found an association of survival with myasthenia gravis. 29,52,53 In this current series, types A and AB thymomas had a similar pattern of recurrence/metastasis and thus can be regarded as a single category.…”

Section: Discussionmentioning

confidence: 99%

WHO types A and AB thymomas: not always benign

Jain

Mehta

Henley³

et al. 2010

Modern Pathology

View full text Add to dashboard Cite

The 2004 WHO classification of thymic tumors recognizes five major subtypes of thymomas and thymic carcinoma. Subtypes A and AB thymomas are purported to be benign neoplasms, although prior studies have suggested a potential for malignant behavior. The purpose of this study was to assess the clinical behavior of A and AB thymomas identified from a large institutional pathologic database. A retrospective slide review of 500 thymic epithelial tumors identified 71 (B14%) cases of types A and AB thymomas. Clinical history and follow-up information were obtained through retrospective chart review. There were 38 and 33 cases of types A and AB thymomas, respectively. Complete follow-up data were available in 37 (52%) cases. Eighteen (49%) patients (type A, n ¼ 9 and type AB, n ¼ 9) had evidence of recurrent/metastatic disease at an average of 62 months (range from 6 to 244 months) after initial diagnosis. Survival curves for patients with types A and AB thymomas, with and without recurrences, show a statistically significant difference (P ¼ 0.001 and 0.005, respectively). Analysis of this large cohort confirms the potential for subtypes A and AB thymomas to show malignant behavior. Long-term clinical monitoring, therefore, appears to be justified in these cases. This study also shows the poor correlation between the WHO classification and tumor behavior

show abstract

Section: Discussionmentioning

confidence: 99%

WHO types A and AB thymomas: not always benign

Jain

Mehta

Henley³

et al. 2010

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…Partial resection has been argued to provide better survival than a simple biopsy in unresectable cases [28].…”

Section: Role Of Surgerymentioning

confidence: 99%

A Review of Thymic Tumors

Bushan

Sharma

Verma

2013

Indian J Surg Oncol

View full text Add to dashboard Cite

Thymic tumors represent 0.2-1.5 % of all malignancies with an incidence of 0.15 per 100,000 population. Thymic tumors are most common tumors of the anterior mediastinum accounting for 20 % of all mediastinal tumors and 50 % of all anterior mediastinal tumors. Over 90 % of all thymic tumors occur in anterior mediastinum, remainder occurring in neck or other mediastinal areas especially aortopulmonary window and retro cardiac area which are common sites for ectopic thymic tissues and possible explanation for failure in some cases of simple thymectomy to improve Myasthenia Gravis(MG). The aim of this review is to discuss histologic classification, diagnostic features, evaluation, management and prognosis of thymic tumors.

show abstract

“…In patients with MG, presenting symptoms typically involve neurologic findings consisting of both systemic and ocular abnormalities. Patients with thymoma and MG may have an increased operative mortality since most surgical deaths can be attributed to MG crisis [6]. For this reason the surgeon should carefully search for signs and symptoms of MG preoperatively in patients with thymoma that offer no previous history of MG. Interestingly, recurrence of thymoma may be higher in those without than in those with MG [7].…”

Section: Clinical Presentationmentioning

confidence: 99%

Thymoma: Update for the New Millenium

et al. 2001

View full text Add to dashboard Cite

USA. Telephone: 210-616-5648; Fax: 210-949-5085; e-mail: cthomas@saci.org www: cancerdata.com Received October 11, 2000; accepted for publication May 11, 2001. ©AlphaMed Press 1083-7159/2001 INTRODUCTIONThymic tumors are common among anterior mediastinal tumors in adults. The vast majority of thymic lesions are thymoma [1]. Thymoma is relatively unique among tumors in that the prognosis appears to be more closely related to the invasive characteristics seen at operation rather than histological appearance. Indeed, the degree of encapsulation and invasion of adjacent tissues define malignancy for these tumors rather than the histologic appearance of the tumor cells [2]. Current treatment of thymoma is often multidisciplinary in nature, and has evolved based upon a growing number of studies to date. These studies have looked at various outcomes based upon associated patient syndromes, tumor histology, and tumor staging, as well as various surgical, radiotherapeutic, chemotherapeutic, and multimodality trials. These studies form the basis of this review.

show abstract

Thymoma: Results of 241 operated cases

Cited by 329 publications

References 15 publications

WHO types A and AB thymomas: not always benign

WHO types A and AB thymomas: not always benign

A Review of Thymic Tumors

Thymoma: Update for the New Millenium

Contact Info

Product

Resources

About