Thymoma: A Population-Based Study of the Management and Outcomes for the Province of British Columbia

Mariano, Caroline; Ionescu, Diana N.; Cheung, Winson Y.; Ali, Rola H.; Laskin, Janessa; Evans, Ken; Carolan, Hannah; Murray, Nevin

doi:10.1097/jto.0b013e318276241c

Cited by 34 publications

(21 citation statements)

References 28 publications

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“…The recurrence rate of thymoma and thymic carcinomas varies according to different reports (Ruffini et al, 2014;Mizuno et al, 2015). Disease-free survival rates in our study were similar to previously published reports (Mariano et al, 2013;Luo et al, 2016). One interesting patient had metastatic thymoma disease at initial presentation and was treated with chemotherapy followed by radiotherapy and surgery.…”

Section: Discussionsupporting

confidence: 89%

Treatment Outcome and Prognostic Factors of Malignant Thymoma - A Single Institution Experience

Alothaimeen

Memon

2020

Asian Pac J Cancer Prev

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Objective: Our objectives are to investigate the clinicopathological features, treatment modalities, and prognostic and prognostic factors in order to estimate long-term outcomes for patients with thymoma and thymic carcinoma at our institution. Methods: We reviewed all patients diagnosed with thymic malignancies malignancies over a period of 38 years (from 1976 to 2014). Patients were identified using a single institution database at King Faisal Specialist Hospital and Research Center (KFSH and RC), Riyadh. Demographic data, clinical staging, histopathology classification, treatment approaches, and survival data were collected. Data Analysis was performed using both the Kaplan-Meier method and Cox proportional hazards modeling. Results: The fifty-six identified patients consists of 30 females (53.6%) and 26 males (46.4%). The median age at diagnosis was 39 years. About 37% of the patients were diagnosed with myasthenia gravis (MG). There was a significant association between the WHO histologic classification and the Masaoka stage (p= 0.018). The estimated 5-year overall survival rate was 88.6% for patients with thymic malignancies. The median survival time of thymoma and thymic carcinoma was 61 and 14 months, respectively. The univariate analysis suggested that histology (thymoma versus thymic carcinoma, p= 0.044) and Masaoka stage (II-III versus IV, p= 0.048) were independent prognostic factors affecting overall survival. Histology (p = 0.044) was found to be an independent predictor of overall survival. Conclusion: The findings of this study indicates that late Masaoka-Koga staging and histology types are significantly associated with extended overall survival. Similarly, surgical resection and multimodality treatments play a significant role in thymic malignancies neoplasms therapy strategies to prolong survival rates.

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Section: Discussionsupporting

confidence: 89%

Treatment Outcome and Prognostic Factors of Malignant Thymoma - A Single Institution Experience

Alothaimeen

Memon

2020

Asian Pac J Cancer Prev

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“…Furthermore, cases that were diagnosed as thymic carcinoma by any reviewer were excluded because thymic carcinomas have consistently been shown to be a distinct group of tumors that have a worse outcome than thymomas. 17,21,23,24 Our agreement rate of 62.0% for WHO classification of thymomas is higher than some of the previously reported rates, likely because our study includes only three reviewers and all reviewers have expertise in thoracic pathology and work together in one department. In contrast to our study, Zucali et al 7 reported a 49% agreement among four reviewers, at least one of which was a surgical pathologist without a specific interest in thymic malignancies.…”

Section: Discussioncontrasting

confidence: 52%

Modified Masaoka Stage and Size Are Independent Prognostic Predictors in Thymoma and Modified Masaoka Stage Is Superior to Histopathologic Classifications

Roden

Jenkins

et al. 2015

Journal of Thoracic Oncology

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“…However, other investigators did not find age to be an important prognostic factor in thymoma. 7,14,15 Size of the tumor is a controversial prognostic factor in thymoma. Blumberg and colleagues 14 found that patients with tumors >11 cm had a worse prognosis, and Wright and colleagues 7 found that patients with tumors >8 cm had a worse prognosis than patients with smaller tumors.…”

Section: Discussionmentioning

confidence: 99%

Resection of thymoma should include nodal sampling

Weksler

Pennathur

Sullivan

et al. 2015

The Journal of Thoracic and Cardiovascular Surgery

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Thymoma: A Population-Based Study of the Management and Outcomes for the Province of British Columbia

Abstract: Survival rates in this population-based series were comparable to those in previously published reports. The ideal management of thymic tumors involves a multidisciplinary approach, particularly in locally advanced disease and selection of patients for adjuvant radiation therapy.

Cited by 34 publications

References 28 publications

Treatment Outcome and Prognostic Factors of Malignant Thymoma - A Single Institution Experience

Treatment Outcome and Prognostic Factors of Malignant Thymoma - A Single Institution Experience

Modified Masaoka Stage and Size Are Independent Prognostic Predictors in Thymoma and Modified Masaoka Stage Is Superior to Histopathologic Classifications

Resection of thymoma should include nodal sampling

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