Thymol enriched bacterial cellulose hydrogel as effective material for third degree burn wound repair

Jiji, Swaminathan; Udhayakumar, Sivalingam; Rose, C.; Muralidharan, C.; Kadirvelu, K.

doi:10.1016/j.ijbiomac.2018.10.192

Cited by 101 publications

(87 citation statements)

References 33 publications

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“…26 Cellulose hydrogels of bacterial origin loaded with thymol exhibited antimicrobial activity and promoted rapid wound closure of third degree burn wounds. 27 Essential oil molecules are often volatile with a very low solubility in aqueous media. While their extraction can be performed in toxic organic solvents, supercritical carbon dioxide (scCO 2 ) extraction of essential oils is now widely used and studied as an environmentally-friendly extraction technology for high-quality oils.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Cellulose Nanofibril Porous Materials Obtained by Supercritical Impregnation of Thymol

Darpentigny

Marcoux

Menneteau

et al. 2020

ACS Appl. Bio Mater.

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Cellulose Nanofibril Porous Materials Obtained by Supercritical Impregnation of Thymol

Darpentigny

Marcoux

Menneteau

et al. 2020

ACS Appl. Bio Mater.

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“…Modifications of biomaterials with different EOs are presented in Table 2. Jiji et al [65] incorporated thymol (which is primarily isolated from Thymus vulgaris EO) into bacterial cellulose hydrogel in order to improve biological properties of the biomaterial. The introduced modification not only increased the antibacterial activity against E. coli, S. aureus, P. aeruginosa, and K. pneumoniae, but also promoted faster wound closure in the in vivo rat animal model.…”

Section: Essential-oil-loaded Biomaterialsmentioning

confidence: 99%

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

Vivcharenko

Przekora

2021

Applied Sciences

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The great variety of wounds and the lack of an effective universal treatment method has resulted in high demand for modern treatment strategies. Traditional approaches are often ineffective on a variety of chronic wounds, such as venous ulcers or the diabetic foot ulcer. There is strong evidence that naturally derived bioactive compounds have pro-healing properties, raising a great interest in their potential use for wound healing. Plant-derived compounds, such as curcumin and essential oils, are widely used to modify materials applied as wound dressings. Moreover, dressing materials are more often enriched with vitamins (e.g., L-ascorbic acid, tocopherol) and drugs (e.g., antibiotics, inhibitors of proteases) to improve the skin healing rate. Biomaterials loaded with the above-mentioned molecules show better biocompatibility and are basically characterized by better biological properties, ensuring faster tissue repair process. The main emphasis of the presented review is put on the novel findings concerning modern pro-healing wound dressings that have contributed to the development of regenerative medicine. The article briefly describes the synthesis and modifications of biomaterials with bioactive compounds (including curcumin, essential oils, vitamins) to improve their pro-healing properties. The paper also summarizes biological effects of the novel wound dressings on the enhancement of skin regeneration. The current review was prepared based on the scientific contributions in the PubMed database (supported with Google Scholar searching) over the past 5 years using relevant keywords. Scientific reports on the modification of biomaterials using curcumin, vitamins, and essential oils were mainly considered.

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“…A peculiar problem is represented by burn injuries that necessitate the development of specific therapeutic materials endowed also with antibacterial activity against infectious microbes prevalent in burns [ 59 ]. A thymol enriched bacterial cellulose HG (BCT-HG) appeared suitable as burn wound dressing material, being effective against Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa and Klebsiella pneumoniae and possessing in vivo good wound healing property in rats bearing third degree burn wounds [ 34 ]. However, some natural polyphenols are used as components of HGs for purposes different from the bioproperties mentioned before.…”

Section: Potential Biomedical Applications Of (Poly)phenols Loadedmentioning

confidence: 99%

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

et al. 2020

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This review deals with hydrogels as soft and biocompatible vehicles for the delivery of plant-derived (poly)phenols, compounds with low general toxicity and an extraordinary and partially unexplored wide range of biological properties, whose use presents some major issues due to their poor bioavailability and water solubility. Hydrogels are composed of polymeric networks which are able to absorb large amounts of water or biological fluids while retaining their three-dimensional structure. Apart from this primary swelling capacity, hydrogels may be easily tailored in their properties according to the chemical structure of the polymeric component in order to obtain smart delivery systems that can be responsive to various internal/external stimuli. The functionalization of the polymeric component of hydrogels may also be widely exploited to facilitate the incorporation of bioactive compounds with different physicochemical properties into the system. Several prototype hydrogel systems have been designed for effective polyphenol delivery and potential employment in the treatment of human diseases. Therefore, the inherent features of hydrogels have been the focus of considerable research efforts over the past few decades. Herein, we review the most recent advances in (poly)phenol-loaded hydrogels by analyzing them primarily from the therapeutic perspective and highlighting the innovative aspects in terms of design and chemistry.

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Thymol enriched bacterial cellulose hydrogel as effective material for third degree burn wound repair

Cited by 101 publications

References 33 publications

Antimicrobial Cellulose Nanofibril Porous Materials Obtained by Supercritical Impregnation of Thymol

Antimicrobial Cellulose Nanofibril Porous Materials Obtained by Supercritical Impregnation of Thymol

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

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