Thymol attenuates the worsening of atopic dermatitis induced by Staphylococcus aureus membrane vesicles

Kwon, Hyo Il; Jeong, Na Hee; Jun, So Hyun; Son, Joo Hee; Kim, Shukho; Jeon, Hyejin; Kang, Sun Chul; Kim, Sang Hyun; Lee, Je Chul

doi:10.1016/j.intimp.2018.04.027

Cited by 25 publications

(14 citation statements)

References 47 publications

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“…However, after several hours of colonization, S. aureus decreased the number of TJs and, subsequently, that of two other types of epidermal junctions, adherent junctions (AJs) and desmosomes, whereas under the same conditions, S. epidermidis showed a minor effect. Other studies focused on cell viability and inflammation revealed that pathogenic strains such as S. aureus or C. acnes or their metabolites induced cell cytotoxicity and increased the production of pro-inflammatory cytokines in skin cells [ 113 , 114 ].…”

Section: Future Insightsmentioning

confidence: 99%

Challenges in exploring and manipulating the human skin microbiome

Cenizo²,

et al. 2021

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The skin is the exterior interface of the human body with the environment. Despite its harsh physical landscape, the skin is colonized by diverse commensal microbes. In this review, we discuss recent insights into skin microbial populations, including their composition and role in health and disease and their modulation by intrinsic and extrinsic factors, with a focus on the pathobiological basis of skin aging. We also describe the most recent tools for investigating the skin microbiota composition and microbe-skin relationships and perspectives regarding the challenges of skin microbiome manipulation.

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Section: Future Insightsmentioning

confidence: 99%

Challenges in exploring and manipulating the human skin microbiome

Cenizo²,

et al. 2021

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“…For instance, disrupted EVs produced by S. aureus ATCC 25923 strain were shown to be four times less cytotoxic than intact EVs [65]. Again, whole and lysed EVs derived from strain 03ST17 were both cytotoxic and proinflammatory, however, these properties were more intense when EVs were intact [38,62]. Nevertheless, in some cases, EV integrity does not influence their cytotoxic properties, as it is the case of S. aureus M060 EVs, that in both intact and disrupted states had the same cytotoxicity levels towards HaCaT cells [65].…”

Section: S Aureus-evs Delivery To Host Cells 51 S Aureus-evs Integmentioning

confidence: 98%

“…Non-cytotoxic to host cells (Hep-2) [31] 03ST17 143 Non-cytotoxic to host cells (Hep-2, HaCaT) [31,38] Cytotoxic to host cells (HaCaT) [62] Immunomodulation in vitro and in vivo (e.g., ↑ IL-1β, IL-6, IL-8, TNF-α, and MCP-1) [38,62] Mast cell recruitment and exacerbation of skin inflammation 06ST1048 Cytotoxic to host cells (Hep-2) [29,31] 143 Delivery of Spa protein through EVs (Hep-2) [29] 8325-4 Induction of the MAPK pathway (THP-1 and MLE-12) [63] Cytotoxicity to host cells (HeLa) [64] Hemolytic activity [63,64] 8325-4Δhla Low cytotoxic to host cells (HeLa) [64] Weaker induction of MAPK pathway (THP-1 and MLE-12) [63] ATCC 14458 90 ND [11] Cytotoxic to host cells (HaCaT) [30] Immunomodulation in vivo (↑ IL-1β and IL-6, ↓ TNF-α)…”

Section: St93mentioning

confidence: 99%

Extracellular Vesicles and Their Role in Staphylococcus aureus Resistance and Virulence

Luz¹,

Azevedo²,

Loir³

et al. 2021

Infectious Diseases

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Staphylococcus aureus is a pathogen of great importance to clinical and veterinary medicine. Recently, there has been a growing interest in S. aureus extracellular vesicles (EVs) in the pathogenesis of this bacterium. Released by living cells into the extracellular milieu, EVs are membranous structures carrying macromolecules such as proteins, nucleic acids, and metabolites. These structures play several physiological roles and are, among others, considered a mechanism of intercellular communication within S. aureus populations but also in trans kingdom interactions. S. aureus EVs were shown to transport important bacterial survival and virulence factors, such as β-lactamases, toxins, and proteins associated with bacterial adherence to host cells, and to trigger the production of cytokines and promote tissue inflammation. In this chapter, we will review the main studies regarding S. aureus EVs, including their composition and roles in host-pathogen interactions, and the possible applications of EVs for vaccines and therapy development against staphylococcal infections.

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“…Thus, S. aureus -EVs may be regarded as one of the therapeutic targets for the management of AD aggravation. Notably, EVs derived from thymol-treated S. aureus or Lactobacillus plantarum alleviated the AD-like skin lesions including epidermal thickening and IL-4 level 171 , 172 , indicating their potential to treat AD.…”

Section: Ev Involvement In the Pathophysiology Of Inflammatory Skin Dmentioning

confidence: 99%

Extracellular vesicles in Inflammatory Skin Disorders: from Pathophysiology to Treatment

Shao¹,

Fang²,

Li³

et al. 2020

Theranostics

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Extracellular vesicles (EVs), naturally secreted by almost all known cell types into extracellular space, can transfer their bioactive cargos of nucleic acids and proteins to recipient cells, mediating cell-cell communication. Thus, they participate in many pathogenic processes including immune regulation, cell proliferation and differentiation, cell death, angiogenesis, among others. Cumulative evidence has shown the important regulatory effects of EVs on the initiation and progression of inflammation, autoimmunity, and cancer. In dermatology, recent studies indicate that EVs play key immunomodulatory roles in inflammatory skin disorders, including psoriasis, atopic dermatitis, lichen planus, bullous pemphigoid, systemic lupus erythematosus, and wound healing. Importantly, EVs can be used as biomarkers of pathophysiological states and/or therapeutic agents, both as carriers of drugs or even as a drug by themselves. In this review, we will summarize current research advances of EVs from different cells and their implications in inflammatory skin disorders, and further discuss their future applications, updated techniques, and challenges in clinical translational medicine.

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Thymol attenuates the worsening of atopic dermatitis induced by Staphylococcus aureus membrane vesicles

Cited by 25 publications

References 47 publications

Challenges in exploring and manipulating the human skin microbiome

Challenges in exploring and manipulating the human skin microbiome

Extracellular Vesicles and Their Role in Staphylococcus aureus Resistance and Virulence

Extracellular vesicles in Inflammatory Skin Disorders: from Pathophysiology to Treatment

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