Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-κB pathway in mast cells

Moon, Phil‐Dong; Kim, Hyung-Min

doi:10.1016/j.cyto.2011.03.007

Cited by 108 publications

(120 citation statements)

References 23 publications

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“…4). In previous study, we reported that caspase-1 is involved in the production of TSLP [23]. Thus, we confirmed the inhibition of TSLP production by the caspase-1 inhibitor in this study (Fig.…”

supporting

confidence: 79%

“…Our previous study showed that TSLP is produced by PMA plus A23187 stimulation [23]. Lesional, but not unaffected, skin from patients with atopic dermatitis expresses high levels of TSLP [34].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the wellestablished roles of caspase 1 in the maturation of IL-1b and IL-18, caspase 1 is also capable of activating the nuclear factor (NF)-kB [15]. The activated caspase-1 activates NF-kB in HMC-1 cells [23]. NF-kB activated by caspase-1 mediates the induction of TSLP gene expression in airway epithelial cells [18].…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that the expression of human TSLP mRNA was controlled by NF-kB in various cells such as fibroblasts and epithelial cells [17,18,26]. The expression and production of TSLP was controlled by NF-kB in mast cells [23]. Rafiee et al [27] reported that curcumin inhibits NF-kB activation in acid-activated HET-1A cells.…”

mentioning

confidence: 99%

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Down-regulation of thymic stromal lymphopoietin by curcumin

Moon

Jeong

Kim

2013

Pharmacological Reports

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Abstract:Background: Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the pathogenesis of allergic diseases such as asthma, atopic dermatitis and allergic rhinitis. Curcumin has various effects such as antidepressant, antioxidant, antihyperglycemic, antitumor and anti-inflammatory. However, the effect of curcumin on the production of TSLP has not been clarified. Thus, we investigated how curcumin inhibits the expression and production of TSLP in the human mast cell line, HMC-1 cells. Methods: We used enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, luciferase assay, and caspase-1 assay to investigate the effects of curcumin. Results:The results show that curcumin inhibited the production and mRNA expression of TSLP in HMC-1 cells: the maximal inhibition rate of TSLP production by curcumin (50 µM) was 59.16 ± 4.20%. In addition, curcumin suppressed the nuclear factor-kB luciferase activity induced by phorbol myristate acetate plus A23187. In the activated HMC-1 cells, caspase-1 activity was increased, whereas caspase-1 activity was decreased by pretreatment with curcumin. Conclusion: These results suggest that curcumin can be used to treat inflammatory and atopic diseases through the suppression of TSLP.

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supporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Down-regulation of thymic stromal lymphopoietin by curcumin

Moon

Jeong

Kim

2013

Pharmacological Reports

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“…TSLP is produced in the epidermis, airway and skin epithelia, and submucosa, playing a crucial role in the sensitization process and exacerbation of allergic diseases [57]. Similar to IL-33/ IL-33R, mast cells can either produce TSLP through IgE/Agmediated signaling (via caspase-1/NF-κB activation in the HMC-1 mast cell line [58]), or be the target of TSLP activation through membrane-bound TSLPR that associates with IL-7Ra to form a fully functional receptor with high affinity to TSLP compared to TSLPR alone [59]. Mature mast cells release Th2 cytokines in response to TSLP and IL-1, suggesting a mechanism that may skew asthmatic patients to a Th2-driven response [60].…”

Section: The Tslp/tslpr Axismentioning

confidence: 99%

Mast cell activation: A complex interplay of positive and negative signaling pathways

Sibilano¹,

2014

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Mast cells regulate the immunological responses causing allergy and autoimmunity, and contribute to the tumor microenvironment through generation and secretion of a broad array of preformed, granule-stored and de novo synthesized bioactive compounds. The release and production of mast cell mediators is the result of a coordinated signaling machinery, followed by the FcεRI and FcγR antigen ligation. In this review, we present the latest understanding of FcεRI and FcγR signaling, required for the canonical mast cell activation during allergic responses and anaphylaxis. We then describe the cooperation between the signaling of FcR and other recently characterized membrane-bound receptors (i.e., IL-33R and thymic stromal lymphopoietin receptor) and their role in the chronic settings, where mast cell activation is crucial for the development and the sustainment of chronic diseases, such as asthma or airway inflammation. Finally, we report how the FcR activation could be used as a therapeutic approach to treat allergic and atopic diseases by mast cell inactivation. Understanding the magnitude and the complexity of mast cell signaling is necessary to identify the mechanisms underlying the potential effector and regulatory roles of mast cells in the biology and pathology of those disease settings in which mast cells are activated.Keywords: FcεRI r FcγR r IL-33 r mast cells r TSLP IntroductionMast cells originate in the BM from a lineage-specific multipotent hematopoietic progenitor, circulate as CD34 + precursors until they migrate to tissues and mature into effector cells in the proximity of organs and blood vessels. Mast cells respond to antigenic stimulation through the cross-linking of immunoglobulin E (IgE) bound to high-affinity receptors for IgE (FcεRI) and the activation of the FcγR after IgG binding (reviewed in [1,2]). Upon activation, mast cells release either preformed, granule-stored mediators, such as histamine and proteases, or newly generated mediators, such as eicosanoids, cytokines, and chemokines [3]. Although the basic molecular mechanisms of Ig:Fc activation have been extensively studied in the past 15 years [4][5][6], new molecules regulating the Correspondence: Dr. Barbara Frossi e-mail: barbara.frossi@uniud.it FcR-signaling cascades have recently been characterized, suggesting not only a still vivid interest in the field of mast cell activation and signaling, but also in identifying putative new therapeutic targets for intervention in mast cell dependent disorders. This review will focus on three aspects of mast cell activation/function. First, we give an essential but complete overview of the FcR-mediated activation in mast cells and report on recent advances in IgE-and IgG-mediated signaling. For clarity, we will dissect and analyze the signals derived from each pathway, with particular attention to the newly identified positive or negative molecular players describing -when possible -their implication toward degranulation and cytokine production. Second, we highlight the growing interest aroun...

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Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

et al. 2015

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Oysters (Oys) contain various beneficial components, such as, antioxidants and amino acids. However, the effects of Oys or taurine (Tau), a major amino acid in Oys on bone growth have not been determined. In the present study, we evaluated the effects of Oys or Tau on linear bone growth in a mouse model of protein malnutrition. To make the protein malnutrition in a mouse, we used a low protein diet. Growth plate thickness was increased by Oys or Tau. Bone volume/tissue volume, trabecular thickness, trabecular number, connection density, and total porosity were also improved by Oys or Tau. Oys or Tau increased insulin-like growth factor-1 (IGF-1) levels in serum, liver, and tibia-growth plate. Phosphorylations of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were increased by Oys and by Tau. These findings show that Oys or Tau may increase growth plate thickness by elevating IGF-1 levels and by promoting the phosphorylations of JAK2-STAT5, and suggest that Oys or Tau are growth-promoting substances of potential use in the food and pharmaceutical industries.

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Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-κB pathway in mast cells

Cited by 108 publications

References 23 publications

Down-regulation of thymic stromal lymphopoietin by curcumin

Down-regulation of thymic stromal lymphopoietin by curcumin

Mast cell activation: A complex interplay of positive and negative signaling pathways

Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition

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