Thymic stroma and TFII-I: towards new targeted therapies

Manti, Pierluigi Giuseppe; Trattaro, Sebastiano; Castaldi, Davide; Pezzali, Martina; Spaggiari, Lorenzo; Testa, Giuseppe

doi:10.1016/j.molmed.2021.10.008

Trends in Molecular Medicine

2022

DOI: 10.1016/j.molmed.2021.10.008

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Thymic stroma and TFII-I: towards new targeted therapies

Pierluigi Giuseppe Manti

Sebastiano Trattaro

Davide Castaldi

et al.

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Cited by 3 publications

(1 citation statement)

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“…Owing to the variety of tumor subtypes and the lack of unique morphological and immunological characteristics, progress in thymoma-related studies is relatively slow (33,34). However, molecular mechanistic and clinical research on thymoma has progressed with the development of imaging diagnosis technology, surgical methods, systemic therapy, and radiotherapy technology (35). IL-12 is a cytokine comprising two subunits, of which the b subunit is the IL-12 subunit beta.…”

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confidence: 99%

Identification of cytokines in benign and malignant thymus tumors: based on Mendelian randomization and proteomics

Zhu,

Shi,

Yang

et al. 2024

Front. Endocrinol.

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ObjectiveThe aim of this study was to identify potential causal cytokines in thymic malignancies and benign tumors from the FinnGen database using Mendelian randomization (MR).MethodsIn this study, data from genome-wide association studies (GWAS) of 91 cytokines were used as exposure factors, and those of thymic malignant tumors and thymic benign tumors were the outcome variables. Two methods were used to determine the causal relationship between exposure factors and outcome variables: inverse variance weighting (IVW) and MR-Egger regression. Sensitivity analysis was performed using three methods, namely, the heterogeneity test, the pleiotropy test, and the leave-one-out test.ResultsThere was a causal relationship between the expression of fibroblast growth factor 5, which is a risk factor for thymic malignant tumors, and thymic malignant tumors. C-C motif chemokine 19 expression, T-cell surface glycoprotein CD5 levels, and interleukin-12 subunit beta levels were causally related to thymic malignant tumors and were protective. Adenosine deaminase levels, interleukin-10 receptor subunit beta expression, tumor necrosis factor (TNF)-related apoptosis-inducing ligand levels, and TNF-related activation-induced cytokine levels showed a causal relationship with thymic benign tumors, which are its risk factors. Caspase 8 levels, C-C motif chemokine 28 levels, interleukin-12 subunit beta levels, latency-associated peptide transforming growth factor beta 1 levels, and programmed cell death 1 ligand 1 expression showed a causal relationship with thymic benign tumors, which are protective factors. Sensitivity analysis showed no heterogeneity.ConclusionCytokines showed a causal relationship with benign and malignant thymic tumors. Interleukin-12 subunit beta is a common cytokine that affects malignant and benign thymic tumors.

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confidence: 99%

Identification of cytokines in benign and malignant thymus tumors: based on Mendelian randomization and proteomics

Zhu,

Shi,

Yang

et al. 2024

Front. Endocrinol.

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HOTAIR in solid tumors: Emerging mechanisms and clinical strategies

Liu

2022

Biomedicine & Pharmacotherapy

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A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction

Kuznetsov,

Kalyuzhin,

Mironov

et al. 2023

J. Zhejiang Univ. Sci. B

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Thymic stroma and TFII-I: towards new targeted therapies

Cited by 3 publications

References 48 publications

Identification of cytokines in benign and malignant thymus tumors: based on Mendelian randomization and proteomics

Identification of cytokines in benign and malignant thymus tumors: based on Mendelian randomization and proteomics

HOTAIR in solid tumors: Emerging mechanisms and clinical strategies

A case of vitiligo after COVID-19 vaccination: a possible role of thymic dysfunction

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